Recent Advances of Bioresponsive Nano-Sized Contrast Agents for Ultra-High-Field Magnetic Resonance Imaging

Hu, Hailong

doi:10.3389/fchem.2020.00203

Cited by 31 publications

(17 citation statements)

References 136 publications

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“…MRI shows its great supremacy in the practical application of clinical diagnosis, as well as in biomedical research [3], and is mainly used to obtain high quality images of the inside of the human body. MRI has the advantages of relatively high resolution (25 ÷ 100 µm) and superior tissue penetration depth, while its sensitivity requires substantial improvement compared with the direct optical imaging technique [4]. Moreover, this technique is based on the principles of nuclear magnetic resonance (NMR), a spectroscopic technique used by researchers to obtain chemical and physical information about molecules [2].…”

Section: Introductionmentioning

confidence: 99%

Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

et al. 2021

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Polyether urethane (PU)-based magnetic composite materials, containing different types and concentrations of iron oxide nanostructures (Fe2O3 and Fe3O4), were prepared and investigated as a novel composite platform that could be explored in different applications, especially for the improvement of the image quality of MRI investigations. Firstly, the PU structure was synthetized by means of a polyaddition reaction and then hematite (Fe2O3) and magnetite (Fe3O4) nanoparticles were added to the PU matrices to prepare magnetic nanocomposites. The type and amount of iron oxide nanoparticles influenced its structural, morphological, mechanical, dielectric, and magnetic properties. Thus, the morphology and wettability of the PU nanocomposites surfaces presented different behaviours depending on the amount of the iron oxide nanoparticles embedded in the matrices. Mechanical, dielectric, and magnetic properties were enhanced in the composites’ samples when compared with pristine PU matrix. In addition, the investigation of in vitro cytocompatibility of prepared PU nanocomposites showed that these samples are good candidates for biomedical applications, with cell viability levels in the range of 80–90%. Considering all the investigations, we can conclude that the addition of magnetic particles introduced additional properties to the composite, which could significantly expand the functionality of the materials developed in this work.

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Section: Introductionmentioning

confidence: 99%

Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

et al. 2021

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“…18F-FDG PET/CT parameters: N-SUV max , T-SUV max , T-MTV, and T-TLG. Diagnostic criteria of MRI lung cancer: for MRI image score, 1, 2, 3, 4, and 5 represent certainly negative, possibly negative, uncertain, possibly positive, and certainly positive, respectively [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

The Efficacy of 18F-FDG PET/CT and Superparamagnetic Nanoferric Oxide MRI in the Diagnosis of Lung Cancer and the Value of 18F-FDG PET/CT in the Prediction of Lymph Node Metastasis

Yao

Zuo

Zhang

et al. 2021

Computational and Mathematical Methods in Medicine

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In China, lung cancer is one of the leading causes of death among residents. Early diagnosis is of great significance for early interventional treatment and prolonging survival. PET/CT uses positron radiopharmaceuticals to observe the physiological and biochemical changes of the drug and its metabolites in the body and finally diagnoses the disease. 18F-FDG is a commonly used imaging agent, but its short isotopic half-life limits clinical high-throughput testing. This study retrospectively analyzed the imaging material of 100 lung cancer patients pathologically confirmed. Patients with lymph node metastasis were classified into the LM group ( n = 30 cases), and those with no lymph node metastasis were classified into the NLM group ( n = 70 cases). The results showed that MRI of superparamagnetic nanoferric oxide was better than diagnosis of lung cancer by the 18F-FDG PET/CT and had a high predictive power for lymph node metastasis. These turned out to be high-value lung cancer diagnosis of superparamagnetic nanoferric oxide MRI and high-capacity lymph node metastasis prediction of 18F-FDG PET/CT, which were worthy of implementation.

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“…Therefore the encapsulation or chelation of these CAs by polymeric nanoparticles (particularly smart polymers that react to tumor-specific stimuli such as acidic pH, overexpressed ROS, etc.) has shown great potential to address these disadvantages [ 238 , 241 ]. Experiments focused nowadays on the development of nanogels, polymersomes, micelles and so on in MRI imaging.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Bioimagingmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Recent Advances of Bioresponsive Nano-Sized Contrast Agents for Ultra-High-Field Magnetic Resonance Imaging

Cited by 31 publications

References 136 publications

Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

The Efficacy of 18F-FDG PET/CT and Superparamagnetic Nanoferric Oxide MRI in the Diagnosis of Lung Cancer and the Value of 18F-FDG PET/CT in the Prediction of Lymph Node Metastasis

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

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