Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

Grădinaru, Luiza Madalina; Mȃndru, Mihaela; Drobotă, Mioara; Aflori, Magdalena; Butnaru, Maria; Spiridon, Maria; Doroftei, Florica; Aradoaei, Mihaela; Ciobanu, Romeo Cristian; Vlad, Stelian

doi:10.3390/polym13244316

Cited by 25 publications

(23 citation statements)

References 60 publications

(85 reference statements)

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“…Indeed, the oral or injectable contrast agents have been developed, but only a few works develop external contrast agents by using the NMR method, which is a hazardous objective. We try to obtain some external device with an amplifier role of MRI images [ 39 , 40 ]. In the presence of an external magnetic field when radiofrequency (RF) pulses with Larmor frequency, the nuclei become excited and transit between low and high energy levels.…”

Section: Introductionmentioning

confidence: 99%

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Drobotă¹,

Vlad²,

Grădinaru³

et al. 2022

Materials

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The majority of recent studies have focused on obtaining MRI materials for internal use. However, this study focuses on a straightforward method for preparing gelatin-based materials with iron oxide nanoparticles (G–Fe2O3 and G–Fe3O4) for external use. The newly obtained materials must be precisely tuned to match the requirements and usage situation because they will be in close touch with human/animal skin. The biocompatible structures formed by gelatin, tannic acid, and iron oxide nanoparticles were investigated by using FTIR spectroscopy, SEM-EDAX analysis, and contact angle methods. The physico-chemical properties were obtained by using mechanical investigations, dynamic vapor sorption analysis, and bulk magnetic determination. The size and shape of iron oxide nanoparticles dictates the magnetic behavior of the gelatin-based samples. The magnetization curves revealed a typical S-shaped superparamagnetic behavior which is evidence of improved MRI image accuracy. In addition, the MTT assay was used to demonstrate the non-toxicity of the samples, and the antibacterial test confirmed satisfactory findings for all G-based materials.

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Section: Introductionmentioning

confidence: 99%

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Drobotă¹,

Vlad²,

Grădinaru³

et al. 2022

Materials

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“…Due to their superior physical properties and high biocompatibility, these materials are also used in biomedical fields: in prosthesis development [ 18 ], tissue engineering [ 19 ], drug delivery systems [ 20 ], etc. The versatile chemistry of polyurethanes allows the incorporation of various hydrophilic/hydrophobic segments and specific functional groups into the polymeric backbone, which are able to customize their properties, in order to develop new multifunctional materials for a wide variety of applications [ 21 , 22 , 23 ]. The amphiphilic polyurethanes could self-assemble into micelles in an aqueous medium, a reversible and dynamic process useful for encapsulating hydrophobic, hydrophilic, or amphiphilic agents, providing them with versatile controlled delivery features.…”

Section: Introductionmentioning

confidence: 99%

Development of Polyurethane/Peptide-Based Carriers with Self-Healing Properties

Grădinaru¹,

Bercea²,

Lupu³

et al. 2023

Polymers

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In situ-forming gels with self-assembling and self-healing properties are materials of high interest for various biomedical applications, especially for drug delivery systems and tissue regeneration. The main goal of this research was the development of an innovative gel carrier based on dynamic inter- and intramolecular interactions between amphiphilic polyurethane and peptide structures. The polyurethane architecture was adapted to achieve the desired amphiphilicity for self-assembly into an aqueous solution and to facilitate an array of connections with peptides through physical interactions, such as hydrophobic interactions, dipole-dipole, electrostatic, π–π stacking, or hydrogen bonds. The mechanism of the gelation process and the macromolecular conformation in water were evaluated with DLS, ATR-FTIR, and rheological measurements at room and body temperatures. The DLS measurements revealed a bimodal distribution of small (~30–40 nm) and large (~300–400 nm) hydrodynamic diameters of micelles/aggregates at 25 °C for all samples. The increase in the peptide content led to a monomodal distribution of the peaks at 37 °C (~25 nm for the sample with the highest content of peptide). The sol–gel transition occurs very quickly for all samples (within 20–30 s), but the equilibrium state of the gel structure is reached after 1 h in absence of peptide and required more time as the content of peptide increases. Moreover, this system presented self-healing properties, as was revealed by rheological measurements. In the presence of peptide, the structure recovery after each cycle of deformation is a time-dependent process, the recovery is complete after about 300 s. Thus, the addition of the peptide enhanced the polymer chain entanglement through intermolecular interactions, leading to the preparation of a well-defined gel carrier. Undoubtedly, this type of polyurethane/peptide-based carrier, displaying a sol–gel transition at a biologically relevant temperature and enhanced viscoelastic properties, is of great interest in the development of medical devices for minimally invasive procedures or precision medicine.

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“…The magnetic nanoparticles possess a large specific surface area, good surficial modification, and excellent supermagnetism. These properties endowed a wide range of applications of the magnetic nanoparticles in biomedicine, such as the use of Fe 3 O 4 nanoparticles in magnetic resonance imaging ( Gradinaru et al, 2021 ; Wang et al, 2021 ; Khani et al, 2022 ). The good magnetic response makes the magnetic nanoparticles a good assembling property under the magnetic field ( Yu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains

Lin

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Neural stem cell therapy has become a promising cure in the treatment of neurodegenerative disorders. Owing to the anisotropy of the nervous system, the newly derived neurons need not only the functional integrity but also the oriented growth to contact with the partner cells to establish functional connections. So the oriented growth of the newly derived neurons is a key factor in neural stem cell–based nerve regeneration. Nowadays, various biomaterials have been applied to assist in the oriented growth of neural stem cell–derived neurons. However, among these biomaterials, the magnetic materials applied in guiding the neuronal growth are still fewer than the other materials, such as the fibers. So in this work, we developed the magnetic nanochains to guide the oriented growth of neural stem cell–derived neurons. With the guidance of the magnetic nanochains, the seeded neural stem cells exhibited a good arrangement, and the neural stem cell–derived neurons showed well-oriented growth with the orientation of the nanochains. We anticipated that the magnetic nanochains would have huge potential in stem cell–based nerve regeneration.

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Composite Materials Based on Iron Oxide Nanoparticles and Polyurethane for Improving the Quality of MRI

Cited by 25 publications

References 60 publications

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Composite Materials Based on Gelatin and Iron Oxide Nanoparticles for MRI Accuracy

Development of Polyurethane/Peptide-Based Carriers with Self-Healing Properties

Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains

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