Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains

Lin, Xia; Zhang, Chen; Su, Kaiming; Fan, Jiangang; Niu, Yuguang; Yu, Yafeng; Chai, Renjie

doi:10.3389/fbioe.2022.895107

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…Cells in typical tissue, including nerves, muscles, tendons, and blood vessel tissue, all exhibit oriented structural arrangements. For nerves, nerve cells are arranged in an orderly manner along the direction of the microsulcus ( Tian et al, 2004 ; Sperling et al, 2017 ; Xia et al, 2022 ), and skeletal muscle consists of bundled muscle fibers ( Zhuang et al, 2013 ; Ozasa et al, 2018 ). As regards blood vessels, endothelial cells are arranged in an orderly manner parallel to the direction of blood flow ( Chen et al, 2018 ; Rosa et al, 2022 ), while smooth muscle cells are arranged along the perivascular direction ( Shudo et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

Jin²,

Fan³

et al. 2023

Front. Bioeng. Biotechnol.

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The cells and tissue in the human body are orderly and directionally arranged, and constructing an ideal biomimetic extracellular matrix is still a major problem to be solved in tissue engineering. In the field of the bioresorbable vascular grafts, the long-term functional prognosis requires that cells first migrate and grow along the physiological arrangement direction of the vessel itself. Moreover, the graft is required to promote the formation of neointima and the development of the vessel walls while ensuring that the whole repair process does not form a thrombus. In this study, poly (l-lactide-co-ε-caprolactone) (PLCL) shell layers and polyethylene oxide (PEO) core layers with different microstructures and loaded with sodium tanshinone IIA sulfonate (STS) were prepared by coaxial electrospinning. The mechanical properties proved that the fiber membranes had good mechanical support, higher than that of the human aorta, as well as great suture retention strengths. The hydrophilicity of the oriented-fiber membranes was greatly improved compared with that of the random-fiber membranes. Furthermore, we investigated the biocompatibility and hemocompatibility of different functional fiber membranes, and the results showed that the oriented-fiber membranes containing sodium tanshinone IIA sulfonate had an excellent antiplatelet adhesion effect compared to other fiber membranes. Cytological analysis confirmed that the functional fiber membranes were non-cytotoxic and had significant cell proliferation capacities. The oriented-fiber membranes induced cell growth along the orientation direction. Degradation tests showed that the pH variation range had little change, the material mass was gradually reduced, and the fiber morphology was slowly destroyed. Thus, results indicated the degradation rate of the oriented-fiber graft likely is suitable for the process of new tissue regeneration, while the random-fiber graft with a low degradation rate may cause the material to reside in the tissue for too long, which would impede new tissue reconstitution. In summary, the oriented-functional-fiber membranes possessing core–shell structures with sodium tanshinone IIA sulfonate/polyethylene oxide loading could be used as tissue engineering materials for applications such as vascular grafts with good prospects, and their clinical application potential will be further explored in future research.

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Section: Introductionmentioning

confidence: 99%

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

Jin²,

Fan³

et al. 2023

Front. Bioeng. Biotechnol.

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Development of the inner ear and regeneration of hair cells after hearing impairment

Bing,

Liu,

Cao

et al. 2023

Fundamental Research

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Application of magnetism in tissue regeneration: recent progress and future prospects

Guan,

Gao,

Liu

et al. 2024

Regenerative Biomaterials

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Tissue regeneration is a hot topic in the field of biomedical research in this century. Material composition, surface topology, light, ultrasonic, electric field and magnetic fields (MFs) all have important effects on the regeneration process. Among them, MFs can provide nearly non-invasive signal transmission within biological tissues, and magnetic materials can convert MFs into a series of signals related to biological processes, such as mechanical force, magnetic heat, drug release, etc By adjusting the MFs and magnetic materials, desired cellular or molecular-level responses can be achieved to promote better tissue regeneration. This review summarizes the definition, classification, and latest progress of MFs and magnetic materials in tissue engineering. It also explores the differences and potential applications of MFs in different tissue cells, aiming to connect the applications of magnetism in various subfields of tissue engineering and provide new insights for the use of magnetism in tissue regeneration.

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Oriented Growth of Neural Stem Cell–Derived Neurons Regulated by Magnetic Nanochains

Cited by 5 publications

References 22 publications

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

Development of the inner ear and regeneration of hair cells after hearing impairment

Application of magnetism in tissue regeneration: recent progress and future prospects

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