Multimodal cancer cell therapy using Au@Fe2O3 core–shell nanoparticles in combination with photo-thermo-radiotherapy

Hosseini, Vahid; Mirrahimi, Mehri; Shakeri‐Zadeh, Ali; Koosha, Fereshteh; Ghalandari, Behafarid; Maleki, Shayan; Komeili, Ali; Kamrava, Seyed Kamran

doi:10.1016/j.pdpdt.2018.08.003

Cited by 74 publications

(28 citation statements)

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“…This tumour microenvironment generally results from the imbalance between the uptake and consumption of oxygen, mainly due to the development of abnormal tumour blood vessels, poor blood flow and the very fast proliferation of cancer cells . Tumour hypoxia is linked to tumour progression and is an important marker of tumour malignancy as it leads to resistance to common therapeutic approaches such as chemotherapy, radiation therapy and photodynamic therapy (PDT) . In recent years, a few therapeutic modalities based on 1) reducing the oxygen consumption rates of tumours, 2) O 2 ‐evolving synergistic chemoradiotherapy, 3) artificial blood to transport oxygen to the hypoxic core and 4) combining oxygen‐enriched gases with vasodilators have emerged to overcome this resistance .…”

Section: Methodsmentioning

confidence: 99%

“…[2,3] Tumour hypoxiai sl inked to tumour progression and is an important marker of tumour malignancya si t leads to resistance to common therapeutic approaches such as chemotherapy,r adiation therapy and photodynamic therapy (PDT). [4,5] In recent years, af ew therapeutic modalities based on 1) reducing the oxygen consumption rates of tumours, 2) O 2 -evolving synergistic chemoradiotherapy,3 )artificial blood to transport oxygen to the hypoxicc ore and 4) combining oxygen-enriched gases with vasodilators have emerged to overcomet his resistance. [6][7][8][9] However,t he clinical application of these treatments is very much restricted by low drug delivery to the hypoxic core and limited oxygen-loading capacity.…”

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confidence: 99%

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In‐Situ Oxygen‐Evolving Photoactive Nanococktail: The Future of Hypoxic Tumour Photodynamic Therapy

Banerjee

2019

ChemBioChem

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

In‐Situ Oxygen‐Evolving Photoactive Nanococktail: The Future of Hypoxic Tumour Photodynamic Therapy

Banerjee

2019

ChemBioChem

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“…Also hybrid NPs, such as copper sulfide [ 182 ] or composed by gold and iron oxide, have been largely employed in the combined PTT-radiation therapy approach. Furthermore, some of these nanohybrids could be potentially activated also by a magnetic stimulation, opening the possibility to insert a third physical input, even if for imaging purposes [ 183 ]. In this context, Mohavedi et al recently deepened the mechanism of this synergy, demonstrating that gold-coated iron oxide core–shell NPs are accumulated in mitochondria after the internalization in KB cancer cells.…”

Section: Combined Stimuli For Enhanced Therapymentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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“…NPs are mainly classified into either organic group, including carbon nanotubes, liposomes, and fullerenes, or inorganic group, including quantum dots and magnetic nanoparticles (MNPs). MNPs can have very interesting properties that make them suitable to be used for applications such as targeted drug delivery, cell sorting, contrast agents for magnetic resonance imaging (MRI), and hyperthermia …”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and hyperthermia cancer therapy of casein‐coated iron oxide nanoparticles in mice

Bani

Hatamie

Haghpanahi

2020

Polymers for Advanced Techs

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Magnetic nanoparticles (MNPs) can be used as heat generation source in cancer hyperthermia therapy. While iron oxide nanoparticles (NPs) are the most popular choice for magnetic hyperthermia, adding a surface enhancement can improve its performance. Furthermore, for MNPs to be used in biomedical application their cytotoxicity needs to be evaluated. In this study biocompatibility and also in vivo performance of casein-coated MNPs were assessed. Cell viability of normal cell lines in all of tests remained above 95% for 0.5 and 1 mg/mL concentration and even the minimum recorded cell viability for normal cell lines was 84.78% at 20 mg/mL concentration. In contrast cell viability of cancer cell lines in contact with casein coated MNPs core-shell structure except for one sample remained below 85%. By introduction of and alternating magnetic field, cell viability of samples with lower MNP concentration dropped by 20% to 30% while this drop for samples with higher concentration was 10% to 20%. Furthermore, results of in vivo trials show that just 1 week of hyperthermia treatment with casein coated MNPs core-shell structure can reduce the tumor size of the mice by 33%. Real-time polymerase chain reaction results further confirmed the effectiveness of this method. Moreover, findings of this study suggest that lower injection speed can improve NPs distribution and treatment effect. Results of this study suggest that core-shell structure can positively affect the tumor growth and the combination of good biocompatibility, innate hostility toward cancer cells and good heating power makes them a good candidate for hyperthermia cancer therapy applications. K E Y W O R D S casein coated iron oxide, cytotoxicity, hyperthermia 1 | INTRODUCTION Nano science is one of the most important research and development frontiers in modern science. Nanotechnology is now widely used throughout the pharmaceutical industry, medicine, electronics, robotics, and tissue engineering. The use of nanoparticle (NP) materials offers many advantages due to their unique size and physical properties. 1 In comparison to bulk materials, NPs have high surface to volume ratio which makes extremely reactive and versatile. These attributes make exiting new opportunities for mechanical, optical, and magnetic applications. 2 NPs are mainly classified into either organic group, including carbon nanotubes, liposomes, and fullerenes, or inorganic group, including quantum dots and magnetic nanoparticles (MNPs). MNPs can have very interesting properties that make them suitable to be used for applications such as targeted drug delivery, cell sorting, contrast agents for magnetic resonance imaging (MRI), and hyperthermia. 3-9 One of the most important features of MNPs is the possibility of manipulation in the presence of a magnetic field gradient. The other advantages of MNPs in biomedical applications are that they can be

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Multimodal cancer cell therapy using Au@Fe2O3 core–shell nanoparticles in combination with photo-thermo-radiotherapy

Cited by 74 publications

References 45 publications

In‐Situ Oxygen‐Evolving Photoactive Nanococktail: The Future of Hypoxic Tumour Photodynamic Therapy

In‐Situ Oxygen‐Evolving Photoactive Nanococktail: The Future of Hypoxic Tumour Photodynamic Therapy

Remotely Activated Nanoparticles for Anticancer Therapy

Biocompatibility and hyperthermia cancer therapy of casein‐coated iron oxide nanoparticles in mice

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