Multimaterial Decomposition Algorithm for the Quantification of Liver Fat Content by Using Fast-Kilovolt-Peak Switching Dual-Energy CT: Clinical Evaluation

Hyodo, Toru; Yada, Norihisa; Hori, Masatoshi; Maenishi, Osamu; Lamb, Peter; Sasaki, Kosuke; Onoda, Mitsuyoshi; Kudo, Masatoshi; Mochizuki, Takashi; Murakami, Takamichi

doi:10.1148/radiol.2017160130

Cited by 86 publications

(73 citation statements)

References 40 publications

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“…Von den 14 Studien zur Fettquantifizierung in der Leber wurde die Fettquantifizierung in der DECT in 9 Studien gegenüber der Histologie verglichen [22][23][24][25][26][27][28][29][30], in 5 gegenüber der MRT-Chemical-Shift-Relaxometrie [5,24,25,27,28], in 4 gegenüber der MRS [5,25,28,29] und in 9 gegenüber der SECT [5,22,24,27,28,[31][32][33][34] (▶ Tab. 1).…”

Section: Ergebnisse: Fettquantifizierung In Der Leberunclassified

“…In den Studien, in denen die DECT gegenüber der Histologie verglichen wurde, wurden die DECT-Daten in den ältesten 1998 und 2003 erschienenen Studien sequenziell generiert [22,23]. Danach erfolgte die DECT-Datenerhebung über die Fast-kVP-Switching-DECT [24,25,27,29,30] sowie ab 2014 partiell auch mit der Dual-Source-DECT [26,28]. Lediglich 2 Studien untersuchten Patienten (v. a. Steatosis im Ultraschall) [22,29], die restlichen Messungen fanden in Ratten oder Kaninchen statt.…”

Section: Stellenwert Der Dect Gegenüber Der Histologieunclassified

“…Danach erfolgte die DECT-Datenerhebung über die Fast-kVP-Switching-DECT [24,25,27,29,30] sowie ab 2014 partiell auch mit der Dual-Source-DECT [26,28]. Lediglich 2 Studien untersuchten Patienten (v. a. Steatosis im Ultraschall) [22,29], die restlichen Messungen fanden in Ratten oder Kaninchen statt. Die Korrelation der DECT-Ergebnisse erfolgte zu den histologischen Graden der Steatosis hepatis.…”

Section: Stellenwert Der Dect Gegenüber Der Histologieunclassified

“…Vergleicht man kontrastmittelgestützte mit nativen Untersuchungen, korrelierten die SECT-Abschwächungskoeffizienten auf nativen Bildern sehr gut bis gut mit der Histologie (r = -0,92 bei 120 kV [23], r = -0,93 bei 90 kV [23], r = -0,868 bei 120 kV [27]), nicht jedoch nach Kontrastmittelgabe (p = 0,365 bei 80 kV oder 140 kV [27]). Auch die durch Materialdekomposition erhobene DECT-FF korrelierte nativ in der Mehrzahl der Studien gut mit der Histologie (r = 0,91 [25], r = 0,517 bis r = 0,816 [29,30]). Im Gegensatz zu den Abschwächungskoeffizienten korrelierte die DECT-FF jedoch sowohl im Kaninchen als auch im Menschen (n = 33) auch nach Kontrastmittelgabe mit den histologischen Steatosisgraden (r = 0,794; p < 0,001 [27,29]).…”

Section: Stellenwert Der Dect Gegenüber Der Histologieunclassified

“…Auch die durch Materialdekomposition erhobene DECT-FF korrelierte nativ in der Mehrzahl der Studien gut mit der Histologie (r = 0,91 [25], r = 0,517 bis r = 0,816 [29,30]). Im Gegensatz zu den Abschwächungskoeffizienten korrelierte die DECT-FF jedoch sowohl im Kaninchen als auch im Menschen (n = 33) auch nach Kontrastmittelgabe mit den histologischen Steatosisgraden (r = 0,794; p < 0,001 [27,29]).…”

Section: Stellenwert Der Dect Gegenüber Der Histologieunclassified

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Dual-Energy Computed Tomography for Fat Quantification in the Liver and Bone Marrow: A Literature Review

Molwitz

Leiderer

Özden

et al. 2020

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Background With dual-energy computed tomography (DECT) it is possible to quantify certain elements and tissues by their specific attenuation, which is dependent on the X-ray spectrum. This systematic review provides an overview of the suitability of DECT for fat quantification in clinical diagnostics compared to established methods, such as histology, magnetic resonance imaging (MRI) and single-energy computed tomography (SECT). Method Following a systematic literature search, studies which validated DECT fat quantification by other modalities were included. The methodological heterogeneity of all included studies was processed. The study results are presented and discussed according to the target organ and specifically for each modality of comparison. Results Heterogeneity of the study methodology was high. The DECT data was generated by sequential CT scans, fast-kVp-switching DECT, or dual-source DECT. All included studies focused on the suitability of DECT for the diagnosis of hepatic steatosis and for the determination of the bone marrow fat percentage and the influence of bone marrow fat on the measurement of bone mineral density. Fat quantification in the liver and bone marrow by DECT showed valid results compared to histology, MRI chemical shift relaxometry, magnetic resonance spectroscopy, and SECT. For determination of hepatic steatosis in contrast-enhanced CT images, DECT was clearly superior to SECT. The measurement of bone marrow fat percentage via DECT enabled the bone mineral density quantification more reliably. Conclusion DECT is an overall valid method for fat quantification in the liver and bone marrow. In contrast to SECT, it is especially advantageous to diagnose hepatic steatosis in contrast-enhanced CT examinations. In the bone marrow DECT fat quantification allows more valid quantification of bone mineral density than conventional methods. Complementary studies concerning DECT fat quantification by split-filter DECT or dual-layer spectral CT and further studies on other organ systems should be conducted. Key points: Citation Format

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Section: Ergebnisse: Fettquantifizierung In Der Leberunclassified

Section: Stellenwert Der Dect Gegenüber Der Histologieunclassified

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Dual-Energy Computed Tomography for Fat Quantification in the Liver and Bone Marrow: A Literature Review

Molwitz

Leiderer

Özden

et al. 2020

Rofo

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The ultrasound‐guided attenuation parameter is useful in quantification of hepatic steatosis in non‐alcoholic fatty liver disease

et al. 2021

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Aim To determine the utility of the ultrasound‐guided attenuation parameter (UGAP) for quantifying hepatic steatosis in non‐alcoholic fatty liver disease (NAFLD). Methods Subjects were 84 patients with NAFLD (53 men, 31 women; mean age 54 [20–81] years) who underwent liver biopsy and ultrasonography using a GE LOGIQ E9 system and C1‐6 probe at our hospital between 2017 and 2020. B‐Mode imaging of segment V in the liver was acquired and echo attenuation was assessed using UGAP. Steatosis score (S0: <5%; S1: 5%–33%; S2: 34%–66%; S3: ≥67%) from liver specimens was compared with the attenuation coefficient (AC; dB/cm/MHz) using UGAP. Results Steatosis score was S0 for 9 patients, S1 for 40, S2 for 21, and S3 for 14. AC by steatosis score was 0.52 ± 0.07, 0.63 ± 0.07, 0.74 ± 0.06, and 0.78 ± 0.06 dB/cm/MHz for S0, S1, S2, and S3, respectively. AC by UGAP differed significantly between S0 and S1, S0 and S2, S0 and S3, S1 and S2, and S1 and S3 (all P < 0.01), demonstrating a significant increase with steatosis score. Receiver operating characteristic analysis showed good diagnostic performance of UGAP for patients with steatosis score ≥1, ≥2, and ≥3 (AUROC = 0.94, 0.95, and 0.88, respectively). Liver fat content (%) from liver specimens and AC (r = 0.81, P < 0.01) showed a significant positive correlation. Conclusion UGAP is useful for quantifying hepatic steatosis in patients with NAFLD.

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Multi‐energy computed tomography and material quantification: Current barriers and opportunities for advancement

et al. 2020

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Computed tomography (CT) technology has rapidly evolved since its introduction in the 1970s. It is a highly important diagnostic tool for clinicians as demonstrated by the significant increase in utilization over several decades. However, much of the effort to develop and advance CT applications has been focused on improving visual sensitivity and reducing radiation dose. In comparison to these areas, improvements in quantitative CT have lagged behind. While this could be a consequence of the technological limitations of conventional CT, advanced dual-energy CT (DECT) and photoncounting detector CT (PCD-CT) offer new opportunities for quantitation. Routine use of DECT is becoming more widely available and PCD-CT is rapidly developing. This review covers efforts to address an unmet need for improved quantitative imaging to better characterize disease, identify biomarkers, and evaluate therapeutic response, with an emphasis on multi-energy CT applications. The review will primarily discuss applications that have utilized quantitative metrics using both conventional and DECT, such as bone mineral density measurement, evaluation of renal lesions, and diagnosis of fatty liver disease. Other topics that will be discussed include efforts to improve quantitative CT volumetry and radiomics. Finally, we will address the use of quantitative CT to enhance image-guided techniques for surgery, radiotherapy and interventions and provide unique opportunities for development of new contrast agents.

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Multimaterial Decomposition Algorithm for the Quantification of Liver Fat Content by Using Fast-Kilovolt-Peak Switching Dual-Energy CT: Clinical Evaluation

Cited by 86 publications

References 40 publications

Dual-Energy Computed Tomography for Fat Quantification in the Liver and Bone Marrow: A Literature Review

Dual-Energy Computed Tomography for Fat Quantification in the Liver and Bone Marrow: A Literature Review

The ultrasound‐guided attenuation parameter is useful in quantification of hepatic steatosis in non‐alcoholic fatty liver disease

Multi‐energy computed tomography and material quantification: Current barriers and opportunities for advancement

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