The ultrasound‐guided attenuation parameter is useful in quantification of hepatic steatosis in non‐alcoholic fatty liver disease

Ogino, Yu; Wakui, Noritaka; Nagai, Hidenari; Igarashi, Yoshinori

doi:10.1002/jgh3.12615

Cited by 9 publications

(7 citation statements)

References 22 publications

(26 reference statements)

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“…Nevertheless, with the progression of fibrosis, AC values were found to be decreasing. The results from this study were limited by its small sample size [18].…”

Section: Discussionmentioning

confidence: 83%

“…The difference in which the steatotic and normal liver attenuates acoustic waves is how the AC measures are quantified [28]. Ogino et al found a positive correlation r = 0.81, P < 0.01 between the AC values and LFC% (liver fat content%), and also good diagnostic accuracy scores for steatosis [18]. Nevertheless, with the progression of fibrosis, AC values were found to be decreasing.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Accuracy of Ultrasonography vs. Elastography in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review

Geethakumari¹,

Kampa²,

Parchuri³

et al. 2022

Cureus

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Ultrasonography and elastography are the most widely used imaging modalities for diagnosing nonalcoholic fatty liver disease. This study aimed to assess and compare the diagnostic accuracy in patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was done for the past seven years using Pubmed, Pubmed Central, Cochrane, and Google Scholar databases on Jun 29, 2022. Studies were included based on the following predefined criteria: observational studies, randomized controlled trial (RCT), comparative studies, studies using liver biopsy or MRI proton density fat fraction (MRI PDFF) as a reference standard, ultrasonography, and elastography with measures of their diagnostic accuracy like sensitivity (SN), specificity (SP), area under the receiver operating characteristic (AUROC) curve, and English language. The data were extracted on a predefined template. The final twelve eligible studies were assessed using the quality assessment of diagnostic accuracy tool (QUADS-2). Most studies focused on elastography techniques, and the remaining focused on quantitative ultrasonography methods like the controlled attenuation parameter (CAP) and attenuation coefficient (AC). Only one study was available for the evaluation of qualitative ultrasonography. MRI was generally found superior to other diagnostic tests for determining liver stiffness through magnetic resonance elastography (MRE) and steatosis through MRI PDFF. Data assessing the comparative diagnostic accuracy of the two tests were inconclusive.

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“…Nevertheless, with the progression of fibrosis, AC values were found to be decreasing. The results from this study were limited by its small sample size [18].…”

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Accuracy of Ultrasonography vs. Elastography in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review

Geethakumari¹,

Kampa²,

Parchuri³

et al. 2022

Cureus

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“…Six published studies compared the UGAP-determined AC values with the reference methods in the assessment of steatosis grades, in which the authors established cut-off values that seemed similar to those obtained via ATI [ 72 , 80 , 82 , 83 , 84 , 85 , 86 ].…”

Section: Quantitative Ultrasound-based Methodsmentioning

confidence: 99%

“…Ogino et al compared the AC obtained using the UGAP with the steatosis grades from liver specimens in 84 patients with NAFLD, and found a significant difference in the AC values among the different grades ( p < 0.01), as well as an increase in AC values with the steatosis score. The liver fat content determined via a pathohistological evaluation of an LB specimen showed a positive correlation with the AC (r = 0.81, p < 0.01), with cut-off values and AUROCs for S1, S2 and S3 of 0.6 (AUROC 0.94), 0.71 (AUROC 0.95) and 0.72 (AUROC 0.88) dB/cm/MHz, respectively [ 83 ].…”

Section: Quantitative Ultrasound-based Methodsmentioning

confidence: 99%

Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal

et al. 2022

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The prevalence of the non-alcoholic fatty liver disease has reached major proportions, being estimated to affect one-quarter of the global population. The reference techniques, which include liver biopsy and the magnetic resonance imaging proton density fat fraction, have objective practical and financial limitations to their routine use in the detection and quantification of liver steatosis. Therefore, there has been a rising necessity for the development of new inexpensive, widely applicable and reliable non-invasive diagnostic tools. The controlled attenuation parameter has been considered the point-of-care technique for the assessment of liver steatosis for a long period of time. Recently, many ultrasound (US) system manufacturers have developed proprietary software solutions for the quantification of liver steatosis. Some of these methods have already been extensively tested with very good performance results reported, while others are still under evaluation. This manuscript reviews the currently available US-based methods for diagnosing and grading liver steatosis, including their classification and performance results, with an appraisal of the importance of this armamentarium in daily clinical practice.

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“…Studies have shown that the ultrasound attenuation imaging (ATI) with a convex array is an accurate diagnostic method for tissue changes in liver, especially steatosis [4][5][6][7][8], but the same technique has yet to be fully explored using a linear probe. Attenuation imaging has been used by Canon in the Aplio series of devices to determining the attenuation coefficient in the assessment of non-alcoholic fatty liver disease [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Confounders of Ultrasound Attenuation Imaging in a Linear Probe Using the Canon Aplio i800 System: A Phantom Study

Hänni,

Ruby,

Paverd

et al. 2024

Diagnostics

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There have been studies showing attenuation imaging (ATI) with ultrasound as an approach to diagnose liver diseases such as steatosis or cirrhosis. So far, this technique has only been used on a convex probe. The goal of the study was to investigate the feasibility of ATI measurements using the linear array on a canon Aplio i800 scanner on certified phantoms. Three certified liver tissue attenuation phantoms were measured in five different positions using a linear probe. The effects of positioning and depth were explored and compared. The values were compared to the certified expected value for each phantom as well as the different measurement values for each measurement position. The ATI measurements on phantoms showed significant effect for the different probe positions and region of interest (ROI) depths. Values taken in the center with the probe perpendicular to the phantom were closest to certified values. Median values at 2.5–4.5 cm depth for phantoms 1 and 2 and 0.5–2.5 cm for phantom 3 were comparable with certified values. Measurements taken at a depth greater than 6 cm in any position were the least representative of the certified values (p-value < 0.01) and had the widest range throughout the different sessions. ATI measurements can be performed with the linear probe in phantoms; however, careful consideration should be given to depth dependency, as it can significantly affect measurement values. Remaining measurements at various depths within the 0.5–6.0 cm range showed deviation from the certified values of approximately 25%.

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The ultrasound‐guided attenuation parameter is useful in quantification of hepatic steatosis in non‐alcoholic fatty liver disease

Cited by 9 publications

References 22 publications

Accuracy of Ultrasonography vs. Elastography in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review

Accuracy of Ultrasonography vs. Elastography in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review

Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal

Confounders of Ultrasound Attenuation Imaging in a Linear Probe Using the Canon Aplio i800 System: A Phantom Study

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