Multifunctional poly(disulfide) hydrogels with extremely fast self-healing ability and degradability

Tran, Van Tron; Mredha, Md. Tariful Islam; Na, Ju Yong; Seon, Jong Keun; Cui, Jiaxi; Jeon, Insu

doi:10.1016/j.cej.2020.124941

Cited by 84 publications

(53 citation statements)

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“…We note that the response time is minutes to a few hours, and thus the translation of a molecular trigger to a macroscopic response can be considered as rapid. Compared to previously reported degradable gels based on breaking disulfides, this depolymerization reaction results in a swift degradation, with the option for even faster responsivity through the acid‐labile cross‐links [9, 10, 40] …”

Section: Resultsmentioning

confidence: 99%

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Dual‐Responsive Material Based on Catechol‐Modified Self‐Immolative Poly(Disulfide) Backbones

et al. 2021

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Functional materials engineered to degrade upon triggering are in high demand due their potentially lower impact on the environment as well as their use in sensing and in medical applications. Here, stimuli‐responsive polymers are prepared by decorating a self‐immolative poly(dithiothreitol) backbone with pendant catechol units. The highly functional polymer is fashioned into stimuli‐responsive gels, formed through pH‐dependent catecholato–metal ion cross‐links. The gels degrade in response to specific environmental changes, either by addressing the pH responsive, non‐covalent, catecholato–metal complexes, or by addition of a thiol. The latter stimulus triggers end‐to‐end depolymerization of the entire self‐immolative backbone through end‐cap replacement via thiol–disufide exchanges. Gel degradation is visualized by release of a dye from the supramolecular gel as it itself is converted into smaller molecules.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Dual‐Responsive Material Based on Catechol‐Modified Self‐Immolative Poly(Disulfide) Backbones

et al. 2021

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“…Compared to previously reported degradable gels based on breaking disulfides,t his depolymerization reaction results in aswift degradation, with the option for even faster responsivity through the acid-labile crosslinks. [9,10,40] Figure 4s hows the absorbance in UV/Vis caused by release of rhodamine 6G from the gels as function of time using the two stimuli (see Figures S22-S24 for raw UV…”

Section: Methodsmentioning

confidence: 99%

Dual‐Responsive Material Based on Catechol‐Modified Self‐Immolative Poly(Disulfide) Backbones

et al. 2021

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Functional materials engineered to degrade upon triggering are in high demand due their potentially lower impact on the environment as well as their use in sensing and in medical applications.H ere,s timuli-responsive polymers are prepared by decorating as elf-immolative poly(dithiothreitol) backbone with pendant catechol units.T he highly functional polymer is fashioned into stimuli-responsive gels,f ormed through pH-dependent catecholato-metal ion cross-links.T he gels degrade in response to specific environmental changes, either by addressing the pH responsive,non-covalent, catecholato-metal complexes,o rb ya ddition of at hiol. The latter stimulus triggers end-to-end depolymerization of the entire self-immolative backbone through end-cap replacement via thiol-disufide exchanges.G el degradation is visualizedb y release of ad ye from the supramolecular gel as it itself is converted into smaller molecules.

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“…Tran 等人 [35] 通过共聚 2,3-二巯基-1-丙醇和内消旋-2,3-二巯基丁二酸制得可降解的自修复水凝胶。水凝胶受损表面中断裂的二硫键产生自由基，自由基可以快速重组或与其他二硫键交换，而表面高密度的羧基和羟基则作为交联剂，快速产生高密度的动态非共价作用，使水凝胶在空气和水下均具有极快的自修复性、优异的拉伸性和快速且完全的降解性。同时，水凝胶还表现出卓越的延展性、良好的导电性、无细胞毒性和生物组织黏附性，并可以作为 "生物墨水"在空气甚至水下进行 3D 打印。 2.5 基于 Diels-Alder 反应的自修复水凝胶共轭二烯和亲二烯体的 Diels-Alder 反应具有良好的热可逆性且反应条件简单，因而被广泛用作自修复水凝胶的化学交联反应 [36,37] 。 Shao 等人 [17]…”

Section: 注射凝胶、3d 生物打印等领域。unclassified

自修复水凝胶材料的设计合成及生物医学应用

Fu¹,

Lu²,

Wang³

et al. 2022

Chin. Sci. Bull.

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Multifunctional poly(disulfide) hydrogels with extremely fast self-healing ability and degradability

Cited by 84 publications

References 50 publications

Dual‐Responsive Material Based on Catechol‐Modified Self‐Immolative Poly(Disulfide) Backbones

Dual‐Responsive Material Based on Catechol‐Modified Self‐Immolative Poly(Disulfide) Backbones

Dual‐Responsive Material Based on Catechol‐Modified Self‐Immolative Poly(Disulfide) Backbones

自修复水凝胶材料的设计合成及生物医学应用

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