Multifunctional nanocone array as solid immunoassay plate and SERS substrate for the early diagnosis of prostate cancer on microfluidic chip

Lu, Yang; Zhan, Changbiao; Yu, Liandong; Yu, Yiyue; Jia, Huakun; Chen, Xiaozhe; Zhang, Dongzhi; Gao, Rongke

doi:10.1016/j.snb.2022.133046

Cited by 17 publications

(8 citation statements)

References 35 publications

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“…This amplication enables the examination of biomolecules such as small compounds, large protein molecules, and even cellular entities. 127,128 In this regard, Lu et al 129 introduced a novel integrated microuidic sensor utilizing SERS, featuring a multifunctional nanocone array (MNA). This remarkable design enables the simultaneous identication of prostate-specic antigen (PSA) and thrombin.…”

Section: +mentioning

confidence: 99%

Sandwich-type aptamer-based biosensors for thrombin detection

Sahraneshin Samani,

Sameiyan,

Tabatabaei Yazdi

et al. 2024

Anal. Methods

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Section: +mentioning

confidence: 99%

Sandwich-type aptamer-based biosensors for thrombin detection

Sahraneshin Samani,

Sameiyan,

Tabatabaei Yazdi

et al. 2024

Anal. Methods

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“…Lu et al developed a new and versatile nanocone array that serves as a solid immunoassay plate and SERS substrate. 320 The nanocone array is coated with a thin Au film, which enhances the surface area and enables efficient antigen capture and conjugation with capture aptamers. This innovative technology enables the simultaneous detection of PSA and thrombin.…”

Section: Applications Of Sers In Disease Diagnosticsmentioning

confidence: 99%

SERS-based microdevices for use as in vitro diagnostic biosensors

Lee,

Dang,

Moon

et al. 2024

Chem. Soc. Rev.

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“…SVM in combination with SERS has been used for the early detection of oral cancer among patients using serum and saliva samples and achieved an accuracy of 80% [ 227 ]. Prostate cancer has been extensively studied and successfully identified using different techniques, such as serum analysis combined with PCA-SVM [ 228 ]; detection of prostate specific antigens [ 229 , 230 , 231 , 232 ]; EVs combined with CNN [ 230 ]; miRNAs [ 233 ]; different multivariate techniques, e.g., PCA-LDA and PCA-SVM [ 234 ]; and urine profiling [ 235 ].…”

Section: Sers For Disease Diagnosismentioning

confidence: 99%

Recent Trends in SERS-Based Plasmonic Sensors for Disease Diagnostics, Biomolecules Detection, and Machine Learning Techniques

2023

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Surface-enhanced Raman spectroscopy/scattering (SERS) has evolved into a popular tool for applications in biology and medicine owing to its ease-of-use, non-destructive, and label-free approach. Advances in plasmonics and instrumentation have enabled the realization of SERS’s full potential for the trace detection of biomolecules, disease diagnostics, and monitoring. We provide a brief review on the recent developments in the SERS technique for biosensing applications, with a particular focus on machine learning techniques used for the same. Initially, the article discusses the need for plasmonic sensors in biology and the advantage of SERS over existing techniques. In the later sections, the applications are organized as SERS-based biosensing for disease diagnosis focusing on cancer identification and respiratory diseases, including the recent SARS-CoV-2 detection. We then discuss progress in sensing microorganisms, such as bacteria, with a particular focus on plasmonic sensors for detecting biohazardous materials in view of homeland security. At the end of the article, we focus on machine learning techniques for the (a) identification, (b) classification, and (c) quantification in SERS for biology applications. The review covers the work from 2010 onwards, and the language is simplified to suit the needs of the interdisciplinary audience.

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Multifunctional nanocone array as solid immunoassay plate and SERS substrate for the early diagnosis of prostate cancer on microfluidic chip

Cited by 17 publications

References 35 publications

Sandwich-type aptamer-based biosensors for thrombin detection

Sandwich-type aptamer-based biosensors for thrombin detection

SERS-based microdevices for use as in vitro diagnostic biosensors

Recent Trends in SERS-Based Plasmonic Sensors for Disease Diagnostics, Biomolecules Detection, and Machine Learning Techniques

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