Multifactorial analysis of risk factors for reduced bone mineral density among postmenopausal women

Bączyk, Grażyna; Opala, Tomasz; Kleka, Paweł; Chuchracki, Marek

doi:10.5114/aoms.2012.28562

Cited by 27 publications

(22 citation statements)

References 30 publications

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“…Within and across women, naturally-occurring conception cycles are characterized by higher average follicular estradiol levels and luteal progesterone levels than non-conception cycles (35-37) and assisted reproductive technologies are more successful in cycles with higher follicular estradiol prior to ovarian stimulation (38, 39). Beyond fertility, ovarian hormones may play an important role in osteoporosis (40, 41), reproductive cancers (42-44), and cardiovascular disease(45, 46). …”

Section: Introductionmentioning

confidence: 99%

Differences in ovarian hormones in relation to parity and time since last birth

Barrett

Parlett

Windham

et al. 2014

Fertility and Sterility

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Objective To examine ovarian function in relation to parity and time since last birth. Design Women collected daily urine samples for up to 8 menstrual cycles. Urinary estradiol and progesterone metabolite concentrations (E1C and PdG) were measured using enzyme-linked immunoassay. Cycle phase lengths were calculated from hormone profiles and daily diaries. Setting California, U.S.A. Patients Three hundred forty-six naturally cycling women, age 18-39. Intervention(s) None. Main Outcome Measure(s) Mean follicular E1C (cycle days −8 to −1), mean luteal PdG (days 0 to +10), and cycle phase lengths in ovulatory cycles. Results Women who had given birth within the previous three years had lower E1C than nulliparas (β=−0.22, 95% CI: −0.33, −0.11) and women who last gave birth >3 years earlier (β=−0.13, 95% CI: −0.23, −0.03). Among parous women, E1C was positively associated with time since last birth (β=0.02, 95% CI: 0.01, 0.04). Women who last gave birth >3 years earlier had longer follicular phases than nulliparas (β=1.18, 95% CI: 0.02, 2.34). There were no associations between parity and PdG or luteal phase length. Conclusions Our cross-sectional data suggest that ovarian function differs in nulliparous and parous women and is positively associated with time since last birth. Longitudinal research is needed to explore within-woman changes in ovarian function pre- and post-partum.

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Section: Introductionmentioning

confidence: 99%

Differences in ovarian hormones in relation to parity and time since last birth

Barrett

Parlett

Windham

et al. 2014

Fertility and Sterility

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“…Se ha estimado que más de un 30% de los pacientes prescritos con glucocorticoides desarrollarán fracturas por fragilidad ósea, siendo destacable que el riesgo de fracturas vertebrales es particularmente elevado y se ha estimado entre 2 a 5 veces mayor dependiendo la dosis diaria recibida (4) . Sin embargo, debido a que un importante número de pacientes están recibiendo DDD de prednisolona menores a las En un estudio realizado en el Caribe colombiano se encontró que de la totalidad de los pacientes estudiados con prescripción de corticoides la mayoría pertenecían al sexo femenino, similar a lo encontrado en nuestro trabajo, datos que pueden indicar que un importante porcentaje de la población estudiada presenta como factor de riesgo las alteraciones hormonales dadas por la posmenopausia (14)(15)(16) , entre otros factores de riesgo.…”

Section: Discussionunclassified

Baja frecuencia de prescripción de profilaxis para osteoporosis en pacientes en tratamiento crónico con corticoides en Colombia

Machado‐Alba

Alzate-Carvajal

Mondragón-Cardona

et al. 2013

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Identificar la frecuencia de uso de medicamentos para prevención de osteoporosis inducida por corticoides (OIC) en pacientes que reciben corticoides por un periodo mayor a tres meses y que son afiliados al Sistema General de Seguridad Social en Salud de Colombia. Materiales y métodos. Estudio de tipo transversal. Se utilizó información sobre, las personas afiliadas al Sistema General de Seguridad Social en Salud de Colombia (3,7 millones). Se incluyeron en el trabajo los usuarios de todas las edades y sexos a los cuales se les indicó algún glucocorticoide entre el 1 de agosto y 30 de noviembre de 2011.Se identificaron variables sociodemográficas y las características de prescripción de glucocorticoides y medicamentos para profilaxis de OIC con dosis expresadas en dosis diarias definidas (DDD). Resultados. Se obtuvo una base de datos de 255 568 prescripciones de glucocorticoides, de los cuales 1837 pacientes recibían algún glucocorticoide de manera crónica. Predominaron pacientes de sexo femenino (60,2%), edad promedio de 55,2±16,9 años distribuidos en 65 ciudades del país. El glucocorticoide más utilizado fue prednisolona en 1546 (84,1%), mientras que el medicamento para profilaxis más prescrito fue calcitriol (67,1%). Se encontraron 994 casos (54,2%) que no estaban recibiendo profilaxis para osteoporosis a pesar de requerirlo. Conclusiones. Existe un bajo empleo de profilaxis para OIC. Se recomienda implementar acciones de farmacovigilancia que permitan identificar problemas relacionados con medicamentos para prevenir eventos adversos y optimizar recursos, anticipándose a la aparición de complicaciones para el paciente. Palabras clave: Glucocorticoides; Calcitriol; Alendronato; Osteoporosis; Prevención secundaria; Farmacoepidemiología; Farmacovigilancia (fuente: DeCS BIREME). LOW FREQUENCY OF PROPHYLAXIS PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS RECEIVING CHRONIC TREATMENT WITH CORTICOSTEROIDS IN COLOMBIA ABSTRACTObjective. To identify the frequency of drug use for the prevention of corticosteroid induced osteoporosis (CIO) among patients using corticosteroids for more than three months affiliated to the General Social Health Security System of Colombia. Materials and methods. Cross-sectional study. Information about people affiliated to the General Social Health Security System of Colombia (3.7 million) was used. This study included men and women of all ages having been prescribed any glucocorticoid from August 1 to November 30, 2011. Sociodemographic variables and the characteristics of of the glucocorticoid prescription and CIO prophylaxis drugs in a defined daily dose (DDD) were identified. Results. A database of 255,568 prescriptions of glucocorticoids was obtained, with a total of 1,837 patients receiving some glucocorticoid chronically. The majority of participants were females (60.2%), with an average age of 55.2±16.9 years distributed in 65 cities of the country. Prednisolone was the most commonly used glucocorticoid (1,546 patients, 84.1%), whereas the most prescribed prophylaxis dru...

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“…Baczyk ve ark. tarafından yapılan ve osteoporotik kadınlarla osteopenik kadınların karşılaştırıldığı bir çalışmada gruplar arasında VKİ açısından anlamlı fark gözlenmiş, osteoporotik grubun VKİ değerleri daha düşük bulunmuştur (17).…”

Section: Gereç Ve Yöntemunclassified

Evaluation Of Gynecological Risk Factors In Osteoporosis

Uzun¹,

Köklü²,

Özel³

et al. 2014

Acta Oncol Tur.

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ÖZET Amaç: Bu çalışmada 50 yaş üzeri osteoporozu olan ve olmayan olgularda osteoporoz için jinekolojik risk faktörlerini değerlendirmek amaçlanmıştır. Gereç ve Yöntem: Çalışmaya postmenopozal-senil osteoporoz tanısı alan 127 hasta ve 53 osteoporozu olmayan gönüllü alındı. Katılımcılar yaş, vücut kitle indeksi (VKİ), menarş yaşı, menopoz yaşı, doğum sayısı, düşük-küretaj sayısı, emzirme hikayesi gibi jinekolojik risk faktörleri açısından sorgulandı. Bulgular: Hastaların yaş ortalaması kontrollere göre daha yüksek, VKİ değerleri daha düşüktü (p<0,05). Menopoza girme yaşı hastalarda daha düşük, 12 ay ve üzeri emzirme oranı ise daha yüksekti (p<0,05). Hasta grubunun menapoz yaş ortalaması kontrol grubundan anlamlı olarak düşük bulundu (p<0,05). Bununla birlikte hasta ve kontrol grupları arasında menarş yaşı, doğum sayısı, düşük-küretaj sayıları açısından anlamlı bir fark saptanmadı (p>0,05). Hasta grubunda emziren 117 katılımcının 100'ü (%85.5), kontrol grubunda emziren 51 katılımcının ise 34'ü (%66.7) 12 ay ve üzeri sürede emzirmişti, istatistiksel olarak bu fark anlamlı bulundu (p<0,05). Sonuç: Osteoporoz için jinekolojik risk faktörlerinin belirlenmesi, gerekli önlemlerin alınması ve bu konudaki bilincin artırılması ile osteoporoz nedeniyle oluşabilecek kırıklardan doğan mortalite ve morbidite oranları azaltılabilir. Anahtar Kelimeler: Osteoporoz; Menopoz; Menarş ABSTRACT Objectıve: To evaluate gynecological risk factors in patients with and without osteoporosis who are older than 50 years of age. Material and Methods: One hundred and twenty seven patients with postmenopausal-senile osteoporosis and 53 non-osteoporotic volunteers were included. The subjects were examined in terms of age, body mass index (BMI), risk factors like age at menarche, age at menopause, number of births, numbers of miscarriage and curettage, and history of breast-feeding, Results: The mean age was statistically higher and the mean BMI level was statistically lower in patients (p<0,05). The mean menopause age was significantly lower, and the breast-feeding period equal or more than 12 months was significantly higher in patients (p<0,05). The mean age at menopause in the patient group was significantly lower (p<0,05). However, there was no difference between the patient and the control groups in terms of age at menarche, number of births, numbers of miscarriage and curettage (p>0,05). Hundred out of 117 patients (85.5%) breastfed equal or more than 12 months; 34 out of 51 volunteers (66.7%) breastfed equal or more than 12 months. This difference was found to be significant (p<0.05). Conclusıon: Finding the gynecological risk factors leading to osteoporosis, taking necessary precautions, and increasing the consciousness can decrease the morbidity and mortality ratios of fractures.

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Multifactorial analysis of risk factors for reduced bone mineral density among postmenopausal women

Cited by 27 publications

References 30 publications

Differences in ovarian hormones in relation to parity and time since last birth

Differences in ovarian hormones in relation to parity and time since last birth

Baja frecuencia de prescripción de profilaxis para osteoporosis en pacientes en tratamiento crónico con corticoides en Colombia

Evaluation Of Gynecological Risk Factors In Osteoporosis

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