Multifaceted nanolipidic carriers: a modish stratagem accentuating nose-to-brain drug delivery

Shah, Shailvi; Patel, Amit A.; Prajapati, Bhupendra G.; Alexander, Amit; Pandya, Vidhi; Trivedi, Nidhi; Pandey, Punit; Patel, Samir; Patel, Ravish J.

doi:10.1007/s11051-023-05804-4

Cited by 6 publications

(7 citation statements)

References 100 publications

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“…Nanocarriers, including nanoparticles and liposomes, have several benefits in terms of medication encapsulation, stability, and precise delivery to specific targets. Their diminutive size enables effective transportation over the nasal mucosa, hence enhancing surface area contact and optimizing medication absorption [ 36 ].…”

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

“…Nanocarriers provide a means of safeguarding pharmaceuticals from enzymatic degradation, reducing drug breakdown or elimination, preserving drug stability and improving their solubility, therefore tackling the difficulties arising from the physicochemical characteristics of certain pharmaceutical actives. Moreover, these carriers may be specifically designed to have mucoadhesive characteristics, which enhance their ability to stay on the nasal mucosa for an extended period and facilitate the continuous release of medication with improved therapeutic response [ 36 ].…”

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

“…This characteristic makes them a very promising approach for strengthening the transport of drugs from the nose to the brain. By doing so, they can improve the availability of drugs in the body and enhance the effectiveness of treatments for neurological disorders [ 36 ]. These nanoparticles effectively release the therapeutic payload in the brain, increasing drug concentration in targeted brain locations while limiting systemic exposure.…”

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

“…The improved delivery mechanism potentially enhances the absorption of drugs by the brain and may lower the dose, reducing systemic adverse effects. This targeted approach shows how nanoparticle-based formulations for nose-to-brain drug-delivery systems can revolutionize neurological disorder treatments by improving bioavailability and minimizing systemic impact [ 36 ].…”

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

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Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport

Gandhi,

Shastri,

Shah

et al. 2024

Pharmaceutics

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The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome the challenges associated with conventional drug administration for central nervous system disorders. This emerging field is driven by the anatomical advantages of the nasal route, enabling the direct transport of drugs from the nasal cavity to the brain, thereby circumventing the blood–brain barrier. This review highlights the significance of the anatomical features of the nasal cavity, emphasizing its high permeability and rich blood supply that facilitate rapid drug absorption and onset of action, rendering it a promising domain for neurological therapeutics. Exploring recent developments and innovations in different nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, micelles, nanoemulsions, nanosuspensions, carbon nanotubes, mesoporous silica nanoparticles, and nanogels unveils their diverse functions in improving drug-delivery efficiency and targeting specificity within this system. To minimize the potential risk of nanoparticle-induced toxicity in the nasal mucosa, this article also delves into the latest advancements in the formulation strategies commonly involving surface modifications, incorporating cutting-edge materials, the adjustment of particle properties, and the development of novel formulations to improve drug stability, release kinetics, and targeting specificity. These approaches aim to enhance drug absorption while minimizing adverse effects. These strategies hold the potential to catalyze the advancement of safer and more efficient nose-to-brain drug-delivery systems, consequently revolutionizing treatments for neurological disorders. This review provides a valuable resource for researchers, clinicians, and pharmaceutical-industry professionals seeking to advance the development of effective and safe therapies for central nervous system disorders.

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Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

Section: Advantages Challenges and Barriers In Nose-to-brain Drug Del...mentioning

confidence: 99%

See 2 more Smart Citations

Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport

Gandhi,

Shastri,

Shah

et al. 2024

Pharmaceutics

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“…Recently, the field of nanotechnology has acquired a lot of attention for its ability to effectively diagnose and take care of various kinds of tumours. Nanocarriers are colloidal drug carrier systems having submicron particle sizes typically, less than 500 nm [ 1 ]. For the past few decades, they have been comprehensively examined as they exhibited promising results in the area of drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

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Breaking barriers: Intranasal delivery of brexpiprazole-nanostructured lipid carriers targets the brain for effective schizophrenia treatment

Shah,

Patel,

Pandya

et al. 2023

Journal of Drug Delivery Science and Technology

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Multifaceted nanolipidic carriers: a modish stratagem accentuating nose-to-brain drug delivery

Cited by 6 publications

References 100 publications

Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport

Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Breaking barriers: Intranasal delivery of brexpiprazole-nanostructured lipid carriers targets the brain for effective schizophrenia treatment

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