Multicomponent Reactions: “Kinderleicht”

Abstract

A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is described. A complex product is generated in just one simple step, so simple that children can do it: “kinderleicht”, German for dead easy. Students are stimulated, inspired, and involved in a multilevel active learning process using the Steps to Inquiry framework as a metacognitive tool that raises student awareness regarding scientific process and prompts them to ask their own questions discussing the merits of a mechanism and evaluating its effectiveness before they start their own cycles of inquiry.

Friedländer, Knoevenagel, and Michael Reactions Employing the Same MOF: Synthesis, Structure, and Heterogeneous Catalytic Studies of ([Zn(1,4-NDCA)(3-BPDB)0.5]·(DMF)(MeOH) and [Cd4(1,4-NDCA)4(3-BPDB)4]·2(DMF)

“…The three-component condensation reactions have been performed employing metal oxides . There have been attempts toward multicomponent condensation reactions involving MOFs as well. , Multicomponent reactions involving three or more substrate molecules, to form the desired product, achieve a high atom economy and reduce the number of steps, synthetic efficiency, and simplicity. − In the present study, we explored the three-component reactions that involve benzaldehyde, malononitrile, and ethyl acetoacetate. This reaction can be considered as a cascade reaction involving Knoevenagel condensation and Michael addition reactions (Figure ).…”

Synthesis and characterization of novel hercynite@sulfuric acid and its catalytic applications in the synthesis of polyhydroquinolines and 2,3-dihydroquinazolin-4(1H)-ones

“…Multicomponent reactions have attracted extensive attention due to the fact that they offer a fundamental methodology in organic synthesis. [1][2][3][4] This synthetic method has been utilized to prepare a variety of N-containing heterocycles, which are interesting drugs and useful organic intermediates in synthetic organic chemistry. [5][6][7][8][9] In this regard, dihydropyridines and 2,3dihydroquinazolin-4(1H)-ones are important classes of heterocycles having high nitrogen content.…”

One-pot multicomponent green LED photoinduced synthesis of chromeno[4,3-b]chromenes catalyzed by a new nanophotocatalyst histaminium tetrachlorozincate

“…This interesting strategy can serve as a preferred tool, which has gained attention for traditional multi-step reactions and a new extension has emerged in synthetic organic chemistry as well as in biological scaffolds and the drug discovery eld. [1][2][3][4] The principal reaction parameters such as temperature, solvents and catalyst amount strongly affect the selectivity, versatility and environmental acceptability of a multi-component reaction.…”