Multicentric T-cell Lymphosarcoma in a White-tailed Deer (Odocoileus virginianus)

Abstract

ABSTRACT:An adult female white-tailed deer (Odocoileus virginianus) with a history of shaking, ataxia, and severe debilitation was submitted for examination. Macroscopic lesions included severe emaciation, severe abdominal and mesenteric lymphadenopathy, and several rumen-associated masses. Microscopically, the ruminal masses and lymph nodes were infiltrated by pleomorphic neoplastic lymphocytes. Similar lymphoblasts were associated with the leptomeninges, choroid plexus, and the intestinal mucosa; these cells were intensely positive for CD3 antigen, indicating their T-cell origin. Lymphoproliferative viruses (bovine leukemia virus and malignant catarrhal fever virus) or epizootic hemorrhagic disease virus were not detected by polymerase chain reaction. To our knowledge, this case represents the first report of the immunophenotype of a multicentric lymphosarcoma, metastasis involving the brain, and epitheliotropic lymphoblasts in a whitetailed deer.

Ovarian mucinous cystadenoma in a gray brocket deer (Mazama gouazoupira)

“…15 A uterine adenocarcinoma in a sika deer (Cervus nippon) 22 was also documented. Additionally, fibrosarcoma, 12 mammary adenocarcinoma, 26 concurrent multicentric hemangiosarcoma, and ovarian teratoma 27 have been described in the Pere David's deer (Elaphurus davidianus).…”

“…1,17,25 In addition, there are reports of various noncutaneous neoplasms in the white-tailed deer ( Odocoileus virginianus ), such as ependymoma, 19 astrocytoma, 11 hepatocellular carcinoma, 21 and lymphoma. 15 A uterine adenocarcinoma in a sika deer ( Cervus nippon ) 22 was also documented. Additionally, fibrosarcoma, 12 mammary adenocarcinoma, 26 concurrent multicentric hemangiosarcoma, and ovarian teratoma 27 have been described in the Pere David’s deer ( Elaphurus davidianus ).…”

Pigmented tumors in fallow deer (Dama dama): 11 cases

“…2 Literature citations of other types of neoplasia in cervids are sporadic, and include lymphosarcoma, melanoma, schwannoma, and oligodendroglioma. 4,9,10,15,16 We describe the histopathologic characteristics and clinical history of an unusual series of 11 fallow deer with pigmented tumors.…”

Disseminated T-cell Lymphoma in a Brazilian Porcupine (Coendou Prehensilis)

“…For example, lymphoid proliferations were identified as T immunophenotype in a guinea pig (Cavia porcellus) 7 and in a whitetailed deer (Odocoileus virginianus). 3 A multicentric B-cell lymphoma was reported in captive greater hedgehog tenrecs (Setifer setosus). 2 A T-cell-rich B-cell lymphoma also was identified in a ring-tailed lemur (Lemur catta).…”