Multicentric Metaplastic Breast Carcinoma with Squamous Differentiation

Abstract

Metaplastic breast carcinoma is a rare primary breast malignancy. A 45-year-old female patient presented with multicentric lumps in left breast of 6 months duration and history of axillary lymphadenopathy of 2 months duration. Mammography revealed two high density masses with ill defined margins. Fine needle aspiration cytology was positive for duct carcinoma cells. Histo pathologic examination, reported as "Multicentric infiltrating duct carcinoma with squamous differentiation left breast", grade 2. Immunohistochemistry revealed negativity for ER, PR and positivity for HER-2/neu. We are presenting this rare case for clinical, radiological, histopathological and immunohistochemical study.

Metaplastic carcinoma of the breast with squamous differentiation: prognostic factors and multidisciplinary treatment

“…Below we analyze the characteristics of our patients plus those reported in the literature (Table 1 ). The mean age was 52.5 years; 40% of them had pre-existing breast lesions (cases 2 [ 7 ], 5 [ 8 ], 6 [ 9 ], and 9); tumor size was large in all cases and axillary involvement was present in 50% of cases (cases 3 [ 10 ], 6, 7 [ 11 ], 9, and 10); 70% of patients presented radiological findings of a solid mass, four of them in association with a cystic component (cases 1[ 12 ], 5, 6, and 9). Less than a half of patients were diagnosed using core needle biopsy (cases 1, 4, 6, and 10) and three of them underwent an incomplete surgical resection (cases 7, 8[ 13 ], and 9).…”