Metaplastic carcinoma of the breast with squamous differentiation: prognostic factors and multidisciplinary treatment

Hernández, A.; Benítez, Víctor Manuel Vega; Ruiz, Marta Pavcovich; Hernández, Juan Ramón Hernández

doi:10.1186/s12957-022-02656-5

Cited by 8 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a case report, a patient who received radiation therapy and adjuvant chemotherapy developed recurrent disease and eventually died [ 15 ] . Therefore, multidisciplinary treatment is beneficial for patients in complex individual situations [ 16 ]. One-year and five-year etiology-specific survival rates for breast SCC are 81.6% and 63.5%, respectively [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the breast: a case report

Liu,

Chen,

Hou

2024

Discov Onc

View full text Add to dashboard Cite

Introduction Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging. Case report A 42-year-old woman with a large mass in the right breast underwent modified radical mastectomy. A pathological examination revealed a tumor with central necrosis in it. The tumor had a sarcomatoid growth pattern and the cells were spindle-shaped with severe atypicality. Immunohistochemical staining showed that P63, P53, vimentin, and CKpan were positive, whereas estrogen receptor and C-erbB-2 were negative. Ki-67 proliferation index was as high as 90%. Therefore, a diagnosis of SCC of the right breast was made. The patient received eight cycles of postoperative chemotherapy with paclitaxel and carboplatin, followed by seven cycles of radiotherapy. During follow-up, the patient also had a left thyroid tumor, and postoperative pathology suggested microinvasive follicular carcinoma. Since breast surgery, the patient has remained disease-free for more than four years. Conclusion SCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the breast: a case report

Liu,

Chen,

Hou

2024

Discov Onc

View full text Add to dashboard Cite

show abstract

“…Being rare tumors, there is little data on the optimal treatment regimen for metaplastic squamous breast cancer and its management remains similar to other invasive breast carcinomas ( 6 ). As it was proven that MBC responds poorly to hormonal and chemotherapy regimens in comparison to other triple negative breast invasive breast carcinomas, neoadjuvant radiation therapy in combination with surgical management can improve the clinical outcomes ( 6 , 7 ). Due to the large tumor size and the high rate of local recurrence, modified radical mastectomy is considered as the surgery of choice for MBC ( 6 , 7 ).…”

Section: Discussionmentioning

confidence: 99%

Metaplastic Breast Cancer with Squamous Differentiation: Beyond the Recognized Statistics

Fallatah,

Boumarah,

Hajjaj

et al. 2024

Med Arch

View full text Add to dashboard Cite

Background: Metaplastic breast cancer is a clinically rare subtype of breast carcinomas, accounting for less than 1% of all breast neoplasms, and was not officially recognized till the end of the 20th century as an independent pathological diagnosis. Objective: In this paper, we report a case of metaplastic breast cancer with squamous differentiation in a 51-year-old female, with a succinct review of the literature. Case Report: The patient presented to our outpatient department with a complaint of left breast mass for 2 months duration with a diagnostic workup found to be grade three metaplastic carcinoma with squamous differentiation. The management decision was to proceed with neoadjuvant chemotherapy, followed by surgical intervention based on the tumor cell response to neoadjuvant therapy. Conclusion: Metaplastic breast cancer represents a rare clinical entity, encountered in a minority of patients. The clinical presentation of metaplastic carcinomas in general is similar to other breast cancers, however, metaplastic breast cancer tend to present in later stages as a rapidly growing mass with poor prognosis. The recognized poor prognosis along with rarity necessities having a high index of suspicion for early detection and appropriate management of metaplastic breast cancer.

show abstract

“…Of note, mesenchymal metaplastic phenomena may originate from foci of typical ductal hyperplasia, suggesting the possible existence of nonobligate benign precursors of MpBC (Sabella et al ., 2019). A proportion of MpBCs are exclusively characterized by carcinomatous elements, usually displaying a pure squamous cell carcinoma differentiation (Graziano et al ., 2016; Tejera Hernández et al ., 2022). The more frequent biphasic pattern is that of adenosquamous carcinoma, with solid squamous cell nests admixed with a glandular component, mostly of high grade (Romanucci et al ., 2021).…”

Section: Histopathology Classificationmentioning

confidence: 99%

Metaplastic breast cancer: an all-round multidisciplinary consensus

Corso

Nicosia

Pesapane

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

Metaplastic breast cancer (MpBC) is a rare and aggressive histologic subtype of breast cancer (BC) characterized by the presence of at least two cellular types, commonly epithelial and mesenchymal components. Despite growing evidence that MpBC is a unique entity, it has long been treated as a variant of nonspecial type (NST) BC. MpBC typically shows the phenotype of triple-negative breast cancer (TNBC), but compared to NST-TNBC, it is a relatively chemorefractory tumor associated with worse outcomes. Therefore, there is an urgent need to develop management guidelines specifically for MpBC to improve the prognosis of patients with early MpBC. This expert consensus aims to guide diagnosis and standardize clinical management of early MpBC among treating physicians. We provide guidance on the challenging radiological and pathological diagnosis of MpBC. Evidence on the involvement of genetic predisposition in the development of MpBC is also explored. We emphasize the importance of a multidisciplinary approach for the treatment of patients with early MpBC. The optimal surgery and radiotherapy approach is presented, as well as the opportunity offered by novel therapeutic approaches to increase treatment response in this chemoresistant subtype. Appropriate management of patients with MpBC is critical to reduce the high risk of local and distant recurrence that characterizes this disease. European

show abstract

Metaplastic carcinoma of the breast with squamous differentiation: prognostic factors and multidisciplinary treatment

Cited by 8 publications

References 23 publications

Primary squamous cell carcinoma of the breast: a case report

Primary squamous cell carcinoma of the breast: a case report

Metaplastic Breast Cancer with Squamous Differentiation: Beyond the Recognized Statistics

Metaplastic breast cancer: an all-round multidisciplinary consensus

Contact Info

Product

Resources

About