Multicentre Dose-Ranging Study on the Efficacy of USPIO Ferumoxtran-10 for Liver MR Imaging

Saini, Sanjay; Sharma, Raju; Baron, Richard L.; Turner, David A.; Ros, Pablo R.; Hahn, Peter F.; Small, William; DeLange, E. E.; Stillman, Arthur E.; Edelman, Robert R.; Runge, Val M.; Outwater, Eric K.

doi:10.1053/crad.2000.0504

Cited by 36 publications

(15 citation statements)

References 14 publications

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“…), and the contrast conjugate was delivered to the brain at a dose of 1 g per mouse (0.04 mg/kg Fe) via intracerebroventricular infusion. The dose administered to each mouse was lower than the nontoxic 1.1 mg/kg Fe dose used in humans (Saini et al, 2000). We used the minimum number of animals necessary, as calculated with a power calculation using the mean and SEM and in-house software by Wayne W. LaMorte (Boston University Medical Center, Boston, MA) ("Sample Size Calculations" available to all animal researchers at MGH).…”

Section: Delivery Of Contrast Conjugatesmentioning

confidence: 99%

Imaging Cerebral Gene Transcripts in Live Animals

Liu

Kim²,

Ren³

et al. 2007

J. Neurosci.

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To circumvent the limitations of using postmortem brain in molecular assays, we used avidin-biotin binding to couple superparamagnetic iron oxide nanoparticles (SPIONs) (15-20 nm) to phosphorothioate-modified oligodeoxynucleotides (sODNs) with sequence complementary to c-fos and ␤-actin mRNA (SPION-cfos and SPION-␤actin, respectively) (14 -22 nm). The Stern-Volmer constant for the complex of SPION and fluorescein isothiocyanate (FITC)-sODN is 3.1 ϫ 10 6 /M. We studied the feasibility of using the conjugates for in vivo magnetic resonance imaging (

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Section: Delivery Of Contrast Conjugatesmentioning

confidence: 99%

Imaging Cerebral Gene Transcripts in Live Animals

Liu

Kim²,

Ren³

et al. 2007

J. Neurosci.

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“…oxide tubules have been published, although their dimensions are varied widely. [2] Such tubular materials have mainly been synthesized based on template-based strategies which included direct templates, e.g. porous membranes, [1b,1c] carbon nanotubule [2c] etc.…”

Section: Sol±gel Template Synthesis Of Aluminum Oxide Microtubulesmentioning

confidence: 99%

Superparamagnetic Silica‐Iron Oxide Nanocomposites for Application in Hyperthermia

Chastellain

Petri²,

Gupta

et al. 2004

Adv Eng Mater

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Superparamagnetic iron oxide particles embedded in silica are studied for application in hyperthermia. The temperature increase is studied when submitting the samples to a weak alternating magnetic field. The influence of the iron oxide size distribution, saturation magnetization, out of phase susceptibility and anisotropy constant is discussed. A theoretical calculation of power loss is carried out and agrees with experimental data.

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“…Superparamagnetic iron oxide nanoparticles (SPIONs) are fascinating materials for biomedical applications due to their biocompatibility [1][2][3][4] and capabilities of generating heat when exposed to an alternating magnetic field (AMF) [5]. These features, in combination with their nanoscale size and versatility, render them particularly intriguing over a wide range of disciplines, including drug delivery, magnetic resonance imaging (MRI) and hyperthermia treatment [6], the latter having been recently approved in Europe for the treatment of glioblastoma multiforme [7].…”

Section: Introductionmentioning

confidence: 99%