Multicenter German reference data base for peripheral quantitative computer tomography

Schneider, Peter; Butz, S; Allolio, Bruno; Börner, W.; Klein, Klaus Ulrich; Lehmann, R.; Petermann, K.; Tysarczyk-Niemeyer, G.; Wüster, C.; Zander, Christina; Ziegler, Rosemarie; Reiners, Chr.

doi:10.3233/thc-1995-3201

Cited by 37 publications

(20 citation statements)

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“…The results of lumbar spine and hip BMD were compared with population-based European reference ranges (16,17). Results at the distal radius were compared with a population-based German reference sample (18).…”

Section: Measurementsmentioning

confidence: 99%

Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D

Arlt

Fremerey

Callies

et al. 2002

European Journal of Endocrinology

223

169

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Objective: Standard treatment in hypoparathyroidism consists of calcium and vitamin D (or vitamin D analogs) but does not employ replacement of the actual missing hormone. Only few studies have evaluated the efficacy of calcium/vitamin D treatment in hypoparathyroidism; the impact of chronic hypoparathyroid disease on well-being has not been investigated previously. Design: Cross-sectional, controlled study in 25 unselected women with postsurgical hypoparathyroidism since 6:4^8:0 years (S.D.) on stable treatment with calcium and vitamin D (or analogs) and in 25 controls with a history of thyroid surgery but intact parathyroid function, who were matched for sex, age and time since surgery. Methods: Assessment of well-being and mood using validated questionnaires (the revised version Symptom Checklist 90 (SCL-90-R); the Giessen Complaint List (GBB-24); and the von Zerssen Symptom List (B-L Zerssen)), serum and urinary calcium/phosphorus homeostasis, and in the hypoparathyroid patients also screening for secondary disease by kidney ultrasound, ophthalmological split lamp examination, and measurement of bone mineral density. Results: Serum calcium was in the accepted therapeutic range in the majority of hypoparathyroid patients. However, calcium/phosphorus homeostasis as a whole was clearly non-physiological. Nephrolithiasis was detected in 2 and cataracts in 11 of 25 hypoparathyroid patients. As compared with controls, hypoparathyroid patients had significantly higher global complaint scores in GBB-24 ðP ¼ 0:036Þ; B-L Zerssen ðP ¼ 0:002Þ and SCL-90-R ðP ¼ 0:020Þ with predominant increases in the subscale scores for anxiety, phobic anxiety and their physical equivalents. Conclusions: Current standard treatment in hypoparathyroidism is not only associated with an altered calcium/phosphorus homeostasis but also fails to restore well-being in these patients. Future studies need to address the impact of more physiological treatment options like parathyroid hormone(1 -34) or parathyroid transplantation on well-being and mood in these patients.

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Section: Measurementsmentioning

confidence: 99%

Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D

Arlt

Fremerey

Callies

et al. 2002

European Journal of Endocrinology

223

169

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“…By means of the EFP, multi center data could be cross-calibrated to achieve a larger normal data base for healthy individuals, resulting in the first multi center data base for pQCT [72]. Along with German multi center data of normals [73], reliable data bases became available for comparison in clinical use as well as for comparison with regional differences in bone mineral content. Within the COMAC-B.M.E.…”

Section: Clinical Evaluation Of the Pqct Technologymentioning

confidence: 99%

Quantitative computed tomography at the axial and peripheral skeleton

et al. 1997

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“…Newer, computerized tomographic methods allow a comprehensive analysis of bone struc tures and assessment of bone strength [9,10].…”

Section: Introductionmentioning

confidence: 99%

Influence of Muscle Strength on Bone Strength during Childhood and Adolescence

et al. 1996

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In connection with the prevention of osteoporosis, paediatrics is challenged with ensuring the optimal formation of the skeletal system with maximal bone strength during childhood and youth. Biomechanical use represents the most important stimulus for activating the skeletal system. The measurement of muscle strength (grip strength) in 97 females aged 3-62 years and 71 males aged 3-61 years showed an age-dependent course. On the whole, males have greater strength with a more pronounced increase after puberty, reaching a peak maximum at 25-30 years. Females show a more moderate increase after puberty. In a pilot study, bone strength (as bone strength index – BSI) was analysed at the distal radius using peripheral quantitative computerized tomography (pQCT). BSI was calculated on the basis of the geometric data of the polar moment of resistance in combination with the cortical bone density. BSI values increase with age and reach a peak maximum at 25-30 years. There was a highly significant correlation between BSI and grip strength (r = 0.87). These relationships are especially interesting for therapeutic concepts differentiating between direct and indirect (via the muscle system) influences on the skeletal system. The non-invasive bone strength analysis in combination with muscle strength offer new perspectives for the evaluation of the functional muscle-bone unit.

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Multicenter German reference data base for peripheral quantitative computer tomography

Cited by 37 publications

References 0 publications

Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D

Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D

Quantitative computed tomography at the axial and peripheral skeleton

Influence of Muscle Strength on Bone Strength during Childhood and Adolescence

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