Influence of Muscle Strength on Bone Strength during Childhood and Adolescence

Schönaü, Eckhard; Werhahn, Einhart; Schiedermaier, U.; Mokow, E.; Schießl, H.; Scheidhauer, Klemens; Michalk, Dietrich

doi:10.1159/000184834

Cited by 74 publications

(49 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LBM continues to increase for about 2–3 years after epiphyseal fusion [16]. Bone mass is associated with muscle mass, and therefore the increase in muscle mass may be of importance in the attainment of peak bone mass [17]. Although the majority of patients with isolated GHD have normal GH secretion at final height, some will still be partially or severely GH deficient.…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Body Composition in Adolescents with Childhood-Onset Growth Hormone Deficiency

Boot

Sluis²,

Krenning

et al. 2009

Horm Res Paediatr

View full text Add to dashboard Cite

Background/Aims: The aim of the present study was to evaluate bone mineral density (BMD) and body composition of patients with childhood-onset growth hormone (GH) deficiency (GHD) treated with GH during the transition period. Methods: BMD and body composition, measured by dual-energy X-ray absorptiometry, were evaluated at final height and yearly thereafter during 2 years. Twenty-nine of the 40 patients had also been measured before start and during GH therapy. Results: Mean lumbar spine BMD and bone mineral apparent density (BMAD) as well as total body BMD and lean body mass (LBM) SD score (SDS) were significantly lower than normal at final height and during the 2 years thereafter for all patients. Final-height SDS was related to the change in height SDS as well as in LBM SDS during the first year of GH treatment. LBM SDS decreased significantly in the group of patients with GHD without GH treatment (p < 0.01, n = 19). Fat mass SDS increased in all patients. Conclusion: Mean BMD, BMAD and LBM SDS were significantly lower than normal in adolescents with childhood-onset GHD at and 2 years after the attainment of final height.

show abstract

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Body Composition in Adolescents with Childhood-Onset Growth Hormone Deficiency

Boot

Sluis²,

Krenning

et al. 2009

Horm Res Paediatr

View full text Add to dashboard Cite

show abstract

“…13,14 It therefore could be useful not only to compare bone mass results to an age-specific reference range but also to test whether bone strength (as reflected by bone mass) is adequately adapted to muscle force. 10,15 In the present cross-sectional study, we tested the hypothesis that anticonvulsant monotherapy with VPA or CBZ interfered with the adaptation of the skeletal system to the mechanical requirements during growth and development.…”

mentioning

confidence: 99%

Analysis of the Musculoskeletal System in Children and Adolescents Receiving Anticonvulsant Monotherapy With Valproic Acid or Carbamazepine

et al. 2001

View full text Add to dashboard Cite

ABSTRACT. Objective. To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year.Methods. Thirty-nine patients from 6 to 19 years of age (18 girls) were studied. Total bone mineral content (BMC) and trabecular volumetric bone mineral density were measured at the distal radius using peripheral quantitative computed tomography. Maximum isometric grip force was determined with a standard dynamometer. Alkaline phosphatase activity and deoxypyridinoline (a marker of bone resorption) were assessed in serum and urine, respectively.Results. Trabecular volumetric bone mineral density was significantly decreased in the entire group (z score mean ؎ standard deviation: ؊0.62 ؎ 1.04) and in the subgroup using valproic acid (؊0.75 ؎ 1.18). In the carbamazepine subgroup, there was a similar but nonsignificant trend (؊0.50 ؎ 0.90). Total BMC and isometric maximum grip force were normal in the entire study population (0.10 ؎ 1.22) and in the 2 subgroups. The relationship between BMC and grip force was similar between patients and healthy participants. Urinary levels of deoxypyridinoline were significantly elevated above normal in the whole study population (1.35 ؎ 2.00) and in both the valproic acid and the carbamazepine subgroups.Conclusion. Bone turnover can be increased, but bone mass is adequate in children and adolescents who have uncomplicated idiopathic epilepsy and who receive monotherapy with carbamazepine or valproic acid. Pediatrics 2001;108(6). URL: http://www.pediatrics.org/ cgi/content/full/108/6/e107; anticonvulsant, bone density, bone mass, bone metabolism, muscle.ABBREVIATIONS. CBZ, carbamazepine; VPA, valproic acid; BMD, bone mineral density; vBMD, volumetric bone mineral density; pQCT, peripheral quantitative computed tomography; BMC, bone mineral content; SD, standard deviation.

show abstract

“…Undeniably, the close functional relationship between muscle and bone supports the assumption that this relationship is largely responsible for changes in bone geometry (and therefore bone strength) and thus should be of potential interest when the occurrence of fractures in children and adolescents is studied [39]. …”

Section: Discussionmentioning

confidence: 99%

Do Bone Mineral Density, Bone Geometry and the Functional Muscle-Bone Unit Explain Bone Fractures in Healthy Children and Adolescents?

Beccard

Land²,

Semler³

et al. 2010

Horm Res Paediatr

View full text Add to dashboard Cite

Background/Aims: Because the increasing fracture incidence has not been understood, the present study compares variables of the muscle-bone interaction to examine the hypothesis that an impaired adaptation of bone strength to muscle forces explains this phenomenon. Methods: The forearm of 220 individuals (mean age 11.1 ± 3.2 years; range 5.5–17.4 years) was analyzed by peripheral quantitative computed tomography. Bone mineral content (BMC), bone mineral density, periosteal circumference, cortical area, strength strain index (SSI) and muscle area (MA) were measured at the distal and proximal radius of the non-dominant forearm. Maximum isometric grip force was measured by a dynamometer. The fracture history was evaluated by a questionnaire after a period of 5 ± 1.7 years. Results: During the observational period at least one fracture appeared in 78 children and adolescents (35.5%). Individuals with and without fractures were not different in age, height, weight, and body mass index. Variables of bone mineral density, bone geometry and muscle force were not different between both groups. BMC, MA and SSI were dependent on age and sex. Conclusion: Fracture risk in healthy children and adolescents is not sufficiently explained by volumetric bone mineral density, the skeletal phenotype and indices of the functional muscle-bone unit.

show abstract

Influence of Muscle Strength on Bone Strength during Childhood and Adolescence

Cited by 74 publications

References 6 publications

Bone Mineral Density and Body Composition in Adolescents with Childhood-Onset Growth Hormone Deficiency

Bone Mineral Density and Body Composition in Adolescents with Childhood-Onset Growth Hormone Deficiency

Analysis of the Musculoskeletal System in Children and Adolescents Receiving Anticonvulsant Monotherapy With Valproic Acid or Carbamazepine

Do Bone Mineral Density, Bone Geometry and the Functional Muscle-Bone Unit Explain Bone Fractures in Healthy Children and Adolescents?

Contact Info

Product

Resources

About