Quantitative computed tomography at the axial and peripheral skeleton

Guglielmi, Giuseppe; Schneider, Peter; Lang, Thomas; Giannatempo, G.M.; Cammisa, M; Genant, Harry K.

doi:10.1007/pl00006862

Cited by 58 publications

(29 citation statements)

References 71 publications

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“…They were harvested from fresh-frozen cadavers and the bone mineral density was determined by quantitative computer tomography (pQCT; Stratec Inc., XCT2000, Pforzheim, Germany) [5][6][7]. All specimens clearly showed a loss of the metaphyseal spongiosa as in osteoporotic bones.…”

Section: Specimenmentioning

confidence: 99%

Effective combination of bone substitute and screws in the jail technique: a biomechanical study of tibial depression fractures

Hoelscher-Doht

Lehnert

Frey

et al. 2012

International Orthopaedics (SICOT)

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Section: Specimenmentioning

confidence: 99%

Effective combination of bone substitute and screws in the jail technique: a biomechanical study of tibial depression fractures

Hoelscher-Doht

Lehnert

Frey

et al. 2012

International Orthopaedics (SICOT)

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“…Among these, peripheral quantitative computed tomography (pQCT) measures the volumetric and true three-dimensional density of both cortical and trabecular bone separately with a high level of precision [9], which is difficult when using other methods including dual-energy X-ray absorptiometry (DXA). Relative cortical bone volume, or cortical thickness, was measured by pQCT [10][11][12][13], and biomechanical strength of the bone was noninvasively estimated by calculating density distribution as the Strength Strain Index (SSI) [14].…”

Section: Introductionmentioning

confidence: 99%

Oral Glucocorticoid-Induced Fall in Cortical Bone Volume and Density in Postmenopausal Asthmatic Patients

et al. 2001

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Despite a deepening understanding of the influence of glucocorticoids (GC) on trabecular bone, little is known about GC-induced cortical bone loss. To elucidate the mechanism of GC-induced loss of cortical bone strength with particular reference to cortical bone loss, changes in cortical density, relative cortical volume, and the Strength Strain Index (SSI) based on biomechanical analyses of the geographic distribution of cortical bone material were measured. These parameters were compared, using peripheral quantitative computed tomography (pQCT), among the following age-matched groups: 68 postmenopausal asthmatic patients receiving high-dose oral GC in addition to inhaled GC (oral GC group), 68 postmenopausal asthmatic patients receiving only inhaled GC (inhaled GC group) and 69 postmenopausal controls without asthma or GC therapy (control group). Cortical bone mineral density (BMD) was measured, relative cortical volume was obtained by dividing the cortical area by the total bone area using pQCT (Stratec XCT960), and the Strength Strain Index (SSI) was calculated in the radius based on the density distribution around the axis. Spinal fracture was assessed on lateral radiographs. The number of vertebral fractures per patient correlated highly with cortical BMD, relative cortical volume and SSI values at the radius. The number of vertebral fractures per patient and the number of patients with fracture were similar between the control and inhaled GC group, both being significantly lower than those in the oral GC group. Total BMD, trabecular BMD, cortical BMD, relative cortical volume and SSI were similar between the first two, being significantly higher than in the last group. The slopes of cortical volume-density relationship, however, were identical among the three groups, indicating the persistence of cortical bone remodeling and a similar degree of calcification regardless of GC administration.

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“…pQCT measures the true vBMD, allows for separate assessment of trabecular and cortical bone, and provides an actual assessment of the cross-sectional bone geometry. Thus, pQCT may enhance our understanding of the relationships among bone composition, bone density, and bone strength, offering a comprehensive view of bone structural parameters that affect fracture risk [45].The access to a large and very well-characterized Italian population that was evaluated with this methodology made it possible to test if ERα genotypes are differently associated with tibial bone density and/or geometric parameters. No significant association was found between ERα gene polymorphisms and cortical or trabecular bone density in both sexes, even though both vBMDt and vBMDc were higher in women with XX and PP genotypes with respect to other groups.…”

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confidence: 99%

Relationship of Volumetric Bone Mineral Density and Structural Parameters with ERα Gene Polymorphisms

et al. 2007

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Bone mineral density (BMD) contributes to bone strength, and methods for clinical assessment of bone quality characteristics beyond what can be gathered by BMD are awaited. Peripheral quantitative computed tomography (pQCT) allows for separate assessments of cortical and trabecular bone, providing information on bone geometry. Previous studies examining the relationship between estrogen receptor α (ERα) gene polymorphisms and BMD have been performed in large populations. However, only limited information is available on the possible segregation of ERα gene polymorphisms with bone structural properties. The aim of our study was to evaluate the association of XbaI and PvuII ERα gene polymorphisms with QCT parameters. We studied 900 subjects (541 women, 449 men) participating to the InCHIANTI study. By tibial pQCT we evaluated trabecular volumetric BMD, cortical volumetric BMD, cortical bone area, and cortical thickness (CtTh). Subjects were genotyped for ERα gene PvuII and XbaI polymorphisms. Analysis of variance was used for statistical analysis. Male subjects with PP and XX genotypes had higher geometric parameters, and female subjects with XX and PP genotypes showed higher densitometric parameters than other genotypes; however, the differences did not reach statistical significance. After adjustment for potential confounders, we found a significant (P = 0.002) CtTh difference across PvuII polymorphism in male subjects, with higher CtTh values in PP genotypes with respect to Pp and pp genotypes. These results show a relationship between the presence of the P allele and higher values of CtTh in male subjects, indicating for ERα a role in the control of tibial bone geometry. KeywordsCortical thickness; ERα gene polymorphism; Peripheral bone; Quantitative computed tomography; Volumetric bone mineral density Osteoporosis is a common skeletal disorder characterized by compromised bone strength predisposing the affected individuals to an increased susceptibility to fragility fracture [1]. Bone strength is the result of both bone mineral density (BMD) and bone quality, the latter encompassing a number of factors, such as bone turnover, mineralization, microarchitecture, Correspondence to: M. L. Brandi; E-mail: mbrandi@dmi.unifi.it. The aim of our study was to evaluate the influence of XbaI and PvuII ERα gene polymorphisms on volumetric BMD (vBMD) and on structural parameters assessed using tibial quantitative computed tomography (QCT) in a large and homogeneous population-based sample of Caucasian men and women. NIH Public Access Subjects and Methods The Population SampleInCHIANTI is an epidemiological study performed in two Italian towns located in the Chianti countryside: Greve (11,709 inhabitants, rural area) and Bagno a Ripoli (village of Antella, 4,704 inhabitants, just outside the urban area of Florence). The study population consisted of a random sample of the population aged 65 years and older living in the two catchment areas and 30 men and 30 women randomly selected in each decade between 20 and 70 ye...

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Quantitative computed tomography at the axial and peripheral skeleton

Cited by 58 publications

References 71 publications

Effective combination of bone substitute and screws in the jail technique: a biomechanical study of tibial depression fractures

Effective combination of bone substitute and screws in the jail technique: a biomechanical study of tibial depression fractures

Oral Glucocorticoid-Induced Fall in Cortical Bone Volume and Density in Postmenopausal Asthmatic Patients

Relationship of Volumetric Bone Mineral Density and Structural Parameters with ERα Gene Polymorphisms

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