Multicenter-Emitting Carbon Dots: Color Tunable Fluorescence and Dynamics Monitoring Oxidative Stress In Vivo

Wang, Yi; Guo, Ge; Gao, Jialin; Li, Zhibin; Yin, Xueer; Zhu, Changqing; Xia, Yunsheng

doi:10.1021/acs.chemmater.0c01391

Cited by 38 publications

(38 citation statements)

References 45 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these materials are restricted from use by their toxicity, low sensitivity, and high cost. Therefore, CDs could be an excellent candidate for the determination of Hg 2 + or ClO − ions [ 19 , 20 , 21 , 22 , 23 , 24 ]. For example, fluorescent CDs were synthesized from ascorbic acid and urea and used for the selective determination of Hg 2+ and Cu 2+ ions and bioimaging [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…A fluorescence quenching sensor for Hg 2+ based on CDs was designed by Yang et al [ 20 ], which demonstrated improved selectivity based on the surface structural rational regulation. Wang et al [ 21 ] reported multicenter-emitting CDs for the dynamic monitoring of wound-induced hypochlorous acid burst and oxidative stress in vivo. Nitrogen and phosphorus codoped CDs with long-wavelength emission have been synthesized and applied in sensing ClO − and cell imaging [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

Lee

Tang

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

Nitrogen and sulfur codoped carbon dots (NSCDs) were synthesized via a one-pot hydrothermal method, and citric acid, ethylenediamine, and methyl blue were used as precursors. The obtained NSCDs were spherical with an average size of 1.86 nm. The fluorescence emission spectra of the NSCDs were excitation independent and emitted blue fluorescence at 440 nm with an excitation wavelength at 350 nm. The quantum yield of the NSCDs was calculated to be 68.0%. The NSCDs could be constructed as fluorescent probes for highly selective and sensitive sensing mercuric (Hg2+) and hypochlorite (ClO−) ions. As the addition of Hg2+ or ClO− ions to the NSCDs, the fluorescence intensity was effectively quenched due to dynamic quenching. Under the optimal conditions, the linear response of the fluorescence intensity ranged from 0.7 μM to 15 μM with a detection limit of 0.54 μM and from 0.3 μM to 5.0 μM with a limit of detection of 0.29 μM for Hg2+ and ClO− ions, respectively. Finally, the proposed method was successfully used for quantifying Hg2+ and ClO− ions in spiked tap water samples.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

Lee

Tang

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Several groups have reported reactive oxygen species (ROSs) to be critical signaling molecules for wound healing. [ 13,14,42,43 ] The PPh‐CDs we prepared were shown to display not only low toxicity, NIR emission, a strong response to a slight change in polarity, and chemical stability, but also a lack of reactivity with ROSs. Hence, we set out to use these CDs to determine whether cell polarity is closely related to wound healing.…”

Section: Resultsmentioning

confidence: 99%

“…[ 10–12 ] To date, several groups have reported reactive oxygen species (ROSs) serving as critical signaling molecules for wound healing. [ 13,14 ] It remains to be determined whether cell polarity, as a microenvironment‐related parameter, varies during wound healing.…”

Section: Introductionmentioning

confidence: 99%

Spying on the Polarity Dynamics during Wound Healing of Zebrafish by Using Rationally Designed Carbon Dots

Hu¹,

Yang²,

Qin³

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Wound healing is an essential and complex biological process. Research into its mechanism and factors that influence its effectiveness has led to better treatments. Changes in the microenvironment are demonstrated to affect wound healing. Cell polarity is a significant microenvironment-related parameter that is associated with many physiological and pathological activities. However, dynamic changes in polarity during wound healing have not been investigated. Monitoring cell polarity during wound healing may open up a new avenue for developing better treatments. Here, a method is developed to monitor cell polarity that involved taking advantage of the fascinating optical properties and biocompatibility of carbon dots (CDs). Specifically, near-infrared (NIR) polarity-sensitive N-phenyl-pphenylenediamine (PPh-CDs) are successfully prepared, which exhibit high sensitivity to polarity, with 509-fold stronger fluorescence in dioxane than in water. The PPh-CDs are successfully applied to monitor the changes of lysosomal polarity during starvation conditions. Using this method, dynamic changes of polarity during wound healing of zebrafish are monitored for the first time. Upon an amputation performed at the zebrafish tail, stronger PPh-CDs fluorescence appeared at the wound sites, and the intensity increased for 25 min and then gradually decreased. This report provides an important experimental basis for investigating wound healing by employing polarity-sensitive CDs.

show abstract

“…The mechanism of CDs is debatable due to change in synthetic routes, initial synthetic materials used, surface functional groups, and wide range of size distribution. Some factors, such as toxicity, blood compatibility, rapid excretion from the body, suitable hydrodynamic diameter, and the lowest possible adsorption of proteins, must be taken into account while designing CDs [151,152]. The clinical feasibility studies have reported the concentration-dependent in vivo effects of CDs on the blood components.…”

Section: Challenges and Limitations Of The Usage Of Cds In Cancer Therapymentioning

confidence: 99%

Nanotheranostic Carbon Dots as an Emerging Platform for Cancer Therapy

Adrita

Tasnim

Ryu

et al. 2020

JNT

View full text Add to dashboard Cite

Cancer remains one of the most deadly diseases globally, but carbon-based nanomaterials have the potential to revolutionize cancer diagnosis and therapy. Advances in nanotechnology and a better understanding of tumor microenvironments have contributed to novel nanotargeting routes that may bring new hope to cancer patients. Several low-dimensional carbon-based nanomaterials have shown promising preclinical results; as such, low-dimensional carbon dots (CDs) and their derivatives are considered up-and-coming candidates for cancer treatment. The unique properties of carbon-based nanomaterials are high surface area to volume ratio, chemical inertness, biocompatibility, and low cytotoxicity. It makes them well suited for delivering chemotherapeutics in cancer treatment and diagnosis. Recent studies have shown that the CDs are potential applicants in biomedical sciences, both as nanocarriers and nanotransducers. This review covers the most commonly used CD nanoparticles in nanomedicines intended for the early diagnosis and therapy of cancer.

show abstract

Multicenter-Emitting Carbon Dots: Color Tunable Fluorescence and Dynamics Monitoring Oxidative Stress In Vivo

Cited by 38 publications

References 45 publications

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

One-Pot Hydrothermal Synthesis of Carbon Dots as Fluorescent Probes for the Determination of Mercuric and Hypochlorite Ions

Spying on the Polarity Dynamics during Wound Healing of Zebrafish by Using Rationally Designed Carbon Dots

Nanotheranostic Carbon Dots as an Emerging Platform for Cancer Therapy

Contact Info

Product

Resources

About