Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center

Abstract

Background-Because of its recent identification, few multi-year epidemiologic studies of hMPV infection have been reported.Objective-We sought to retrospectively describe hMPV infections among patients evaluated by a large US Midwestern referral laboratory. Results-34 (2.6%) of 1294 specimens were hMPV positive. Among these, 21 (62%) were culture positive and available for genetic typing. A previously considered rare genotype of hMPV, B1, was the most common single genotype identified, comprising 9 (43%) of the 21 isolates. Multivariate logistic regression modeling identified patients aged 0.4-9 years (OR = 8.9; 95% CI = 2.0-38.5) and those under intensive care (OR = 3.2; 95% CI = 1.1-8.7) as more likely to have hMPV infection than their peers.Conclusion-In this large referral hospital viral assays more often had evidence of hMPV when they were collected from children receiving intensive care.

Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China

“…24,29 The primer pair used in this study can also be applied to an SYBR Green RT-PCR system for quick screening of clinical We observed an annual incidence of 1.7% for hMPV infection in immunocompetent adults with ARTIs, sampled over a period of two consecutive years in China. Similar annual incidences have been reported in the United States of America, 19 the United Kingdom, 16 and in Cambodia. 4 Although the winter-spring season is traditionally regarded as Phylogenetic analysis of hMPV based on partial sequences of the P gene.…”

Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK

“…The 2.3% incidence of hMPV we found in this study is much lower than the 19% incidence we described in the same community during the 2001-2002 winter season but is similar to the 2-3% identified in other studies of archived samples (Gray et al, 2006;Louie et al, 2005;Scheltinga et al, 2005;Sivaprakasam et al, 2007). Others have reported an incidence in paediatric specimens between 5% and 10% varying with age group and period of study (Banerjee et al, 2007;Bouscambert-Duchamp et al, 2005;Debur et al, 2007;Ebihara et al, 2004;Kuypers et al, 2006;Mullins et al, 2004;Sloots et al, 2006).…”

Human Metapneumovirus

“…22 hMPV infection has been detected worldwide, with reports from North and South America, Europe, Asia, Africa, and Australia. 20,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Serologic studies of stored specimens indicate that hMPV has infected humans for at least 5 decades. 3 hMPV infection is seasonal, with winter epidemics occurring from December to April in the northern hemisphere, simultaneous with or slightly later than RSV epidemics ( Fig.…”