Human Metapneumovirus

Hermos, Christina; Vargas, Sara O.; McAdam, Alexander J.

doi:10.1016/j.cll.2009.10.002

Cited by 26 publications

(24 citation statements)

References 107 publications

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“…This virus was discovered in 2001, and while analysis is underway, cases have been reported around the world (1)(2)(3)(4). In Japan, following sporadic reported cases, there have also been reports of outbreaks among children and at facilities for the elderly (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Human Metapneumovirus Infection Prevailing in Hospital Wards Housing Patients with Severe Disabilities

Matsuda

Nakamura²,

Hirano³

et al. 2013

Jpn J Infect Dis

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SUMMARY: Epidemics of infectious diseases often occur at long-term inpatient facilities for patients with severe motor and intellectual disabilities. However, the pathogens causing these infections remain unknown in approximately half of such epidemics. Two epidemics of respiratory tract infection occurred in 2 wards in the National Hospital Organization Ehime Hospital (prevalence 1, 34 infected out of 59 inpatients in the A ward in September 2011; prevalence 2, 8 infected out of 58 inpatients in the B ward in June 2012). Human metapneumovirus (HMPV) was detected from the nasal (and some pharyngeal) swabs from 17 patients. Based on phylogenetic analysis of viral genomes, the virus was grouped in subgroup A2 (prevalence 1) and B2 (prevalence 2). We considered that the viruses had spread through the 2 wards. The average duration of high fever in the 42 patients was 6.8 days, with the majority of fevers exceeding 389 C (79z) and being accompanied by a productive cough. Ten out of 17 patients (59z) in whom HMPV was detected had decreased lymphocyte and increased monocyte counts in the blood. Eleven cases (65z) had elevated-C reactive protein levels and fever protraction as well as images of bronchitis or pneumonia on chest radiographs approximately 1 week after onset. Anti-HMPV antibody in the blood was positive in 95z of patients (151 of 159 inpatients), indicating no relation between HMPV infection and antibody titer but revealing recurrent infections. In view of the fever protraction and frequent co-occurrence of bronchitis and pneumonia at long-term inpatient facilities for immunocompromised patients such as the ones in this study, the prevalence of HMPV must be carefully monitored, and preventive measures and early-stage treatments are required.

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Section: Introductionmentioning

confidence: 99%

Characteristics of Human Metapneumovirus Infection Prevailing in Hospital Wards Housing Patients with Severe Disabilities

Matsuda

Nakamura²,

Hirano³

et al. 2013

Jpn J Infect Dis

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“…For example, although RSV and hMPV are primarily detected in pediatric samples (19,22,34), severe RSV and hMPV infections have been described in adults of all ages with and without underlying disease, such as chronic obstructive pulmonary disease (COPD) or asthma (19,21,22). In addition, infections with these pathogens can have atypical presentations, such as hMPV pericarditis in an otherwise healthy adult (13).…”

Section: Scope Of Respiratory Virus Testingmentioning

confidence: 99%

Current Best Practices for Respiratory Virus Testing

Ginocchio

McAdam

2011

J Clin Microbiol

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2Diagnostic testing for respiratory viruses has been revolutionized by recent advances that have made rapid and highly accurate tests accessible to clinical laboratories, and it is important that these improved methods be utilized. Accurate detection of respiratory viruses is important in patient care, as it guides both therapy and infection control measures. On a larger scale, the CDC and its collaborating laboratories collect both data and isolates from clinical laboratories for national surveillance, and the use of high-quality tests in clinical laboratories can improve the quality of these data.

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“…Both viruses can be transmitted mainly by large droplets from infected individuals [11,12], and the incubation period could last between three and seven days for hRSV and four to six days for hMPV [13]. hRSV and hMPV are present year-round, but their incidence increases in the fall, peaks in the winter and goes down in early spring [1,14,15]. Host risk factors for these infections include premature birth, congenital heart disease, immunodeficiency, elderly individuals, gender and Down’s syndrome, among others [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections

Guerrero-Plata

2013

Viruses

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Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract. Their strategic localization at the site of pathogen entry makes them particularly susceptible to initial viral invasion. Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) belong to the Paramyxoviridae family, within the Pneumovirus and Metapneumovirus genera, respectively. hRSV and hMPV are significant human respiratory pathogens that cause similar clinical manifestations and affect many of the same subpopulations. However, they differentially activate the host immune response, including DC, which represents a fundamental link between the innate and adaptive immune response. In this review, the role of DC in the immune response against hRSV and hMPV infections, as well as the inhibitory effects of these paramyxoviruses on the DC immunity will be discussed.

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Human Metapneumovirus

Cited by 26 publications

References 107 publications

Characteristics of Human Metapneumovirus Infection Prevailing in Hospital Wards Housing Patients with Severe Disabilities

Characteristics of Human Metapneumovirus Infection Prevailing in Hospital Wards Housing Patients with Severe Disabilities

Current Best Practices for Respiratory Virus Testing

Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections

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