Multi-vendor multi-site T1ρ and T2 quantification of knee cartilage

Kim, J.; Mamoto, K.; Lartey, Richard; Xu, Kenong; Nakamura, Kunio; Shin, Wanyong; Winalski, Carl S.; Obuchowski, Nancy A.; Tanaka, Masae; Bahroos, Emma; Link, Thomas M.; Hardy, Peter; Peng, Qi; Reddy, Ravinder; Bemden, Angie Botto-van; Liu, K.; Peters, Robert; Wu, Chia‐Ju; Li, X.

doi:10.1016/j.joca.2020.07.005

Cited by 30 publications

(40 citation statements)

References 41 publications

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“…Test-retest variability (nonlongitudinal) of cartilage T2 and T1r values are measurable at the knee with a within-subject coefficient of variation of 4%-5%. This claim applies to 3.0-T scanners from the same vendor (2,23,25,27,39).…”

Section: Claimmentioning

confidence: 99%

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The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage

Chalian¹,

Li²,

Guermazi³

et al. 2021

Radiology

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MRI-based cartilage compositional analysis shows biochemical and microstructural changes at early stages of osteoarthritis before changes become visible with structural MRI sequences and arthroscopy. This could help with early diagnosis, risk assessment, and treatment monitoring of osteoarthritis. Spin-lattice relaxation time constant in rotating frame (T1r) and T2 mapping are the MRI techniques best established for assessing cartilage composition. Only T2 mapping is currently commercially available, which is sensitive to water, collagen content, and orientation of collagen fibers, whereas T1r is more sensitive to proteoglycan content. Clinical application of cartilage compositional imaging is limited by high variability and suboptimal reproducibility of the biomarkers, which was the motivation for creating the Quantitative Imaging Biomarkers Alliance (QIBA) Profile for cartilage compositional imaging by the Musculoskeletal Biomarkers Committee of the QIBA. The profile aims at providing recommendations to improve reproducibility and to standardize cartilage compositional imaging. The QIBA Profile provides two complementary claims (summary statements of the technical performance of the quantitative imaging biomarkers that are being profiled) regarding the reproducibility of biomarkers. First, cartilage T1r and T2 values are measurable at 3.0-T MRI with a within-subject coefficient of variation of 4%-5%. Second, a measured increase or decrease in T1r and T2 of 14% or more indicates a minimum detectable change with 95% confidence. If only an increase in T1r and T2 values is expected (progressive cartilage degeneration), then an increase of 12% represents a minimum detectable change over time. The QIBA Profile provides recommendations for clinical researchers, clinicians, and industry scientists pertaining to image data acquisition, analysis, and interpretation and assessment procedures for T1r and T2 cartilage imaging and test-retest conformance. This special report aims to provide the rationale for the proposed claims, explain the content of the QIBA Profile, and highlight the future needs and developments for MRI-based cartilage compositional imaging for risk prediction, early diagnosis, and treatment monitoring of osteoarthritis.

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Section: Claimmentioning

confidence: 99%

“…The magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots technique has been validated in multisite multivendor studies (27,39,42) and has a combined T1r and T2 mapping capability (40). Multisection multiecho sequences have been used to measure cartilage T2 value (49).…”

Section: Profile Activitiesmentioning

confidence: 99%

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage

Chalian¹,

Li²,

Guermazi³

et al. 2021

Radiology

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“…As reliability of measurements is of great concern, repeatability measurements can be recommended to assess the variance caused by subtle differences in handling, as well as sampling errors. In a multiside in vivo study using multiple vendors, coefficients of variations (CV) of 8-10% were found for T1ρ and T2 mapping in healthy volunteers 86 . An earlier systematic review by range for T1ρ and T2 (CVs 2.3-22%, with poorer reproducibility for small subregions) based on only several studies.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis

Emanuel

Kellner

Peters

et al. 2022

Osteoarthritis and Cartilage

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“…More advanced MRI techniques can now be used to assess AC matrix composition non-invasively to detect early articular changes. T2-mapping and T1ρ sequences estimate the relaxation times of water inside AC and have found application in clinical protocols to assess cartilage changes in OA [250]. Diffusion-weighted and diffusion tensor imaging can also be used to assess ECM changes in AC since the movement of water in cartilage is affected by ECM composition and structure.…”

Section: Evaluation Of the Aggrecan Content And Distribution In Pathological Cartilage Using Imaging Techniquesmentioning

confidence: 99%

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity

Hayes

Melrose

2020

Biomolecules

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This review examines aggrecan’s roles in developmental embryonic tissues, in tissues undergoing morphogenetic transition and in mature weight-bearing tissues. Aggrecan is a remarkably versatile and capable proteoglycan (PG) with diverse tissue context-dependent functional attributes beyond its established role as a weight-bearing PG. The aggrecan core protein provides a template which can be variably decorated with a number of glycosaminoglycan (GAG) side chains including keratan sulphate (KS), human natural killer trisaccharide (HNK-1) and chondroitin sulphate (CS). These convey unique tissue-specific functional properties in water imbibition, space-filling, matrix stabilisation or embryonic cellular regulation. Aggrecan also interacts with morphogens and growth factors directing tissue morphogenesis, remodelling and metaplasia. HNK-1 aggrecan glycoforms direct neural crest cell migration in embryonic development and is neuroprotective in perineuronal nets in the brain. The ability of the aggrecan core protein to assemble CS and KS chains at high density equips cartilage aggrecan with its well-known water-imbibing and weight-bearing properties. The importance of specific arrangements of GAG chains on aggrecan in all its forms is also a primary morphogenetic functional determinant providing aggrecan with unique tissue context dependent regulatory properties. The versatility displayed by aggrecan in biodiverse contexts is a function of its GAG side chains.

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Multi-vendor multi-site T1ρ and T2 quantification of knee cartilage

Cited by 30 publications

References 41 publications

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage

The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity

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