The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis

Emanuel, Kaj S.; Kellner, Lukas; Peters, M.; Haartmans, Mirella J. J.; Hooijmans, Melissa T.; Emans, Pieter J.

doi:10.1016/j.joca.2021.10.016

Cited by 41 publications

(24 citation statements)

References 85 publications

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“…Articular cartilage is a layer of connective tissue encased in the surface of the joint, which has the function of bearing mechanical load, lubricating the joint, maximizing absorption, buffering stress, etc. 1,2 In cases of acute trauma and chronic wear, articular cartilage will suffer from varying degrees of damage, oen causing joint pain, limited mobility, and even loss of function. [3][4][5] Due to the low degree of vascularization, the nutrition of cartilage tissue mainly comes from the joint uid, and its ability to regenerate is very limited if a traumatic or pathological event occurs.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

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“…Cartilage T 2 (spin-spin) relaxation time is primarily dependent on water and collagen content and the structure of the extracellular matrix of cartilage. 4 T 2 relaxation time may increase at the early stages of cartilage degeneration because of damage to the collagen-PG matrix, allowing greater water mobility, as well as an overall increase in water content. Note that cartilage degeneration can also lead to decreased T 2 .…”

Section: Cartilage Compositional Mrimentioning

confidence: 99%

“… 2 It is known that cartilage matrix degradation, including proteoglycan (PG) loss, collagen disruption, and free water content increase, can occur well before visible cartilage morphological changes 3 . Compositional MRI measures correlate with the biochemical 4 and biomechanical 5 properties of cartilage and therefore potentially serve as imaging biomarkers for evaluating early cartilage degeneration. As such, qMRI techniques have been developed to evaluate cartilage matrix changes with the goal of early detection of cartilage and joint degeneration 6 …”

Section: Cartilage Compositional Mrimentioning

confidence: 99%

Quantitative MRI for Evaluation of Musculoskeletal Disease

et al. 2022

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Magnetic resonance imaging (MRI) is a valuable tool for evaluating musculoskeletal disease as it offers a range of image contrasts that are sensitive to underlying tissue biochemical composition and microstructure. Although MRI has the ability to provide high-resolution, information-rich images suitable for musculoskeletal applications, most MRI utilization remains in qualitative evaluation. Quantitative MRI (qMRI) provides additional value beyond qualitative assessment via objective metrics that can support disease characterization, disease progression monitoring, or therapy response. In this review, musculoskeletal qMRI techniques are summarized with a focus on techniques developed for osteoarthritis evaluation. Cartilage compositional MRI methods are described with a detailed discussion on relaxometric mapping (T2, T2*, T1ρ) without contrast agents. Methods to assess inflammation are described, including perfusion imaging, volume and signal changes, contrast-enhanced T1 mapping, and semiquantitative scoring systems. Quantitative characterization of structure and function by bone shape modeling and joint kinematics are described. Muscle evaluation by qMRI is discussed, including size (area, volume), relaxometric mapping (T1, T2, T1ρ), fat fraction quantification, diffusion imaging, and metabolic assessment by 31P-MR and creatine chemical exchange saturation transfer. Other notable technologies to support qMRI in musculoskeletal evaluation are described, including magnetic resonance fingerprinting, ultrashort echo time imaging, ultrahigh-field MRI, and hybrid MRI-positron emission tomography. Challenges for adopting and using qMRI in musculoskeletal evaluation are discussed, including the need for metal artifact suppression and qMRI standardization.

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“…In addition to these biomarkers, imaging can be employed to study changes in articular cartilage. Magnetic resonance imaging (MRI) is particularly suitable for cartilage research, as not only cartilage thickness, but also the composition can be studied, such as changes in proteoglycan and collagen composition [ 54 ]. Among the MRI techniques, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is particularly capable of reflecting the cartilage proteoglycan concentration [ 55 , 56 ].…”

Section: Pathophysiology and Biomarkers Of Joint Cartilage Unloadingmentioning

confidence: 99%

“…Among the MRI techniques, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is particularly capable of reflecting the cartilage proteoglycan concentration [ 55 , 56 ]. An inverse correlation was shown for T1ρ relaxation times and proteoglycan concentrations, and there is also a weak correlation between T2 relaxation times and proteoglycans [ 54 ]. Calcified cartilage, the subchondral bone plate, and the trabecular bone of the subarticular spongiosa are mineralized tissues that can clinically best be analyzed by computed tomography (CT) or peripheral quantitative computer tomography (pQCT) [ 57 , 58 ].…”

Section: Pathophysiology and Biomarkers Of Joint Cartilage Unloadingmentioning

confidence: 99%

Joint Cartilage in Long-Duration Spaceflight

2022

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This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts. Findings from analogue model research, such as bed rest studies, as well as data from animal and cell research in real microgravity indicate that unloading and radiation exposure are associated with joint degeneration in terms of cartilage thinning and changes in cartilage composition. It is currently unknown how much the individual cartilage regions in the different joints of the human body will be affected on long-term missions beyond the Low Earth Orbit. Given the fact that, apart from total joint replacement or joint resurfacing, currently no treatment exists for late-stage osteoarthritis, countermeasures might be needed to avoid cartilage damage during long-duration missions. To plan countermeasures, it is important to know if and how joint cartilage and the adjacent structures, such as the subchondral bone, are affected by long-term unloading, reloading, and radiation. The use of countermeasures that put either load and shear, or other stimuli on the joints, shields them from radiation or helps by supporting cartilage physiology, or by removing oxidative stress possibly help to avoid OA in later life following long-duration space missions. There is a high demand for research on the efficacy of such countermeasures to judge their suitability for their implementation in long-duration missions.

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The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis

Cited by 41 publications

References 85 publications

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Quantitative MRI for Evaluation of Musculoskeletal Disease

Joint Cartilage in Long-Duration Spaceflight

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