Multi-Organ Distant Metastases Confer Worse Disease-Specific Survival in Differentiated Thyroid Cancer

Wang, Laura Y.; Palmer, Frank L.; Nixon, Iain J.; Thomas, D H; Patel, Snehal G.; Shaha, Ashok R.; Shah, Jatin P.; Tuttle, R. Michael; Ganly, Ian

doi:10.1089/thy.2014.0173

Cited by 76 publications

(57 citation statements)

References 17 publications

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“…The prognosis is good with a 5-year survival rate above 85% [1]. However, 1–4% of patients with differentiated thyroid cancer (DTC) present with distant disease at diagnosis, and 7–23% develop metastatic disease during follow-up [4]. These metastases occur mainly in the lungs and bone and decrease the patient’s 10-year survival rate by 50% [5].…”

Section: Introductionmentioning

confidence: 99%

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Matta-Coelho

Simões‐Pereira

Vilar³

et al. 2018

Eur Thyroid J

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Background/Aims: Overall, 2–13% of patients with thyroid cancer develop bone metastases (BM). In addition to decreased survival, patients with BM may present skeletal-related events (SRE) that impair the quality of life. Our objectives were to characterize clinical features, treatment approaches, and outcomes of patients with thyroid cancer and BM. Material and Methods: We identified patients diagnosed with thyroid carcinoma of follicular origin and BM followed at the Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisbon, Portugal, from 1991 to 2017. SRE were defined as the need for bone irradiation, bone surgery, spinal cord compression, or pathologic fractures. Results: The final cohort consisted of 86 patients, with a median follow-up time of 54 months (IQR 22.8–82.8), mainly women (67.4%), and a median age of 64 years (IQR 53.6–71.2). BM was the initial presentation of thyroid cancer in 36.0% of the patients. Bone involvement was multiple in 59.3% of the cases. Papillary carcinoma was the most frequent histological type, present in 47.7% of the patients, of which 56.1% presented the follicular variant. SRE were found in 76.7% of the patients. The most frequent SRE was radiotherapy (66.3%). Treatment with bisphosphonates was initiated in 19.8% of the patients. The 5-year specific survival was 60%, whereas the 10-year specific survival decreased to 50%. There were no differences in 5- or 10-year specific survival regarding gender, the occurrence of SRE, or histological type. However, patients with initial radioiodine non-avid lesions had a lower 5- and 10-year specific survival (p = 0.002). Discussion: The high frequency of patients with SRE was notable. The follicular variant of papillary thyroid cancer was the variant most commonly associated with BM, reflecting a more similar behavior to follicular carcinoma than the classic variant.

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Section: Introductionmentioning

confidence: 99%

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Matta-Coelho

Simões‐Pereira

Vilar³

et al. 2018

Eur Thyroid J

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“…With conventional treatments (surgery, radioiodine, hormone suppression), distant metastases (DM) occur in 3%-7% of cases, most often in the lung [1,2].Treatment of DM patients is based on radioiodine and associated with hormone suppression and locoregional therapies [3,4]. Twothirds of DM patients have 131 I uptake on therapeutic 131 I wholebody scan ( 131 I-WBS), and a half of these achieve remission.…”

Section: Introductionmentioning

confidence: 99%

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

et al. 2015

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Background. Outcomes vary among patients with radioiodine refractory (RR) differentiated thyroid cancer (DTC). The prognostic factors for survival are not well-known, resulting in difficulty in selectingpatients for newtargetedtherapies.We assessed overall survival (OS) and cancer-specific survival (CSS) from RR-DTC to identify prognostic factors associated with survival. Patients and Methods. The data on all cases of metastatic RR-DTC treated in our center from 1990 to 2011 were retrospectively reviewed. Survival was estimated using the Kaplan-Meier method; associated prognostic factors were assessed using Cox's model. Results. Of 153 cases of metastatic DTC, 59% (n 5 91) met a criterion for RR: that is, 60% (n 5 55) had at least 1 metastasis without

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“…The data available on the distant metastasis contribution into the patients survival are significantly different, the 10-year survival term is of wide diapason -from 25 up to 70 % [23,24]. Such a fact may be due to the presence in the groups analyzed of both PTC and FTC patients (according to our data, the 10-years survival term among FTC patients is twice lower comparing to this index for PTC ones).…”

Section: Discussionmentioning

confidence: 55%

Survival of patients with thyroid papillary and follicular carcinoma: similarity and difference of prognostic factors (cohort retrospective study).

Guda

2019

ScienceRise: Medical Science

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A retrospective study has been carried out on the cohort of patients, which were operated because of differentiated thyroid cancers in 1994-2014. The studies were conducted in the clinic of the Institute of Endocrinology, in addition, data from the National Cancer Registry was used. The cohort includes 5,346 patients; among them there are 4,346 women and 1,000 men, their age being from 10 to 84 years (average age 40.9±9.1 years); the PTC diagnosis was made for 4,818 patients, 528 persons were with the FTC diagnosis. The tumor classification was realized according to the 7 th version of the TNM Classification. The information of patients (age and sex, histological type, size and categories of carcinomas, their invasive properties, the presence of multifocal growth), as well as the clinical characteristics of the disease (stage, volume of surgical intervention and radioiodine treatment, risk of

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Multi-Organ Distant Metastases Confer Worse Disease-Specific Survival in Differentiated Thyroid Cancer

Abstract: MODM are associated with a poorer survival compared to patients with SODM. A serum Tg level >30 ng/mL at the time of first distant metastases confers more than a fivefold risk of having MODM identified during follow-up.

Cited by 76 publications

References 17 publications

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Bone Metastases from Thyroid Carcinoma of Follicular Origin: A Single Institutional Experience

Outcomes and Prognostic Factors in Radioiodine Refractory Differentiated Thyroid Carcinomas

Survival of patients with thyroid papillary and follicular carcinoma: similarity and difference of prognostic factors (cohort retrospective study).

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