Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation

Shalumon, K.T.; Sheu, Chialin; Chen, Chih‐Hao; Chen, Shih‐Heng; Jose, Gils; Kuo, Chang-Yi; Chen, Jyh‐Ping

doi:10.1016/j.actbio.2018.03.044

Cited by 127 publications

(116 citation statements)

References 64 publications

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“…An inorganic/organic composite nanober can be obtained aer the post-treatment. The inorganic materials commonly used in the biomedical eld are TiO 2 , 69 SiO 2 , 70 GO, 73 Ag, 74 Pt, 75 and Au. 76 Blantocas prepared high-efficiency antibacterial TiO 2 /chitosan ber material by chemical vapor depositing titanium dioxide particles onto electrospun chitosan bers.…”

Section: Inorganic/organic Nanobersmentioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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Section: Inorganic/organic Nanobersmentioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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“…The encapsulation of drugs such as mitomycin and ibuprofen within electrospun nanofibers is commonly used to inhibit cell adhesion on the surface of ENMs, but the local side effects of the drugs restrict their clinical applications [15][16][17]. Accordingly, it is very desirable to develop electrospun nanofibers without any drugs to achieve effective antiadhesive performance.…”

Section: Introductionmentioning

confidence: 99%

Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion

et al. 2020

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Lubrication is the key to efficient function of human tissues and has significant impact on the comfort level. However, the construction of a lubricating nanofibrous membrane has not been reported as yet, especially using a one-step surface modification method. Here, bioinspired by the superlubrication mechanism of articular cartilage, we successfully construct hydration-enhanced lubricating nanofibers via one-step in situ grafting of a copolymer synthesized by dopamine methacrylamide (DMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) onto electrospun polycaprolactone (PCL) nanofibers. The zwitterionic MPC structure provides the nanofiber surface with hydration lubrication behavior. The coefficient of friction (COF) of the lubricating nanofibrous membrane decreases significantly and is approximately 65% less than that of pure PCL nanofibers, which are easily worn out under friction regardless of hydration. The lubricating nanofibers, however, show favorable wear-resistance performance. Besides, they possess a strong antiadhesion ability of fibroblasts compared with pure PCL nanofibers. The cell density decreases approximately 9-fold, and the cell area decreases approximately 12 times on day 7. Furthermore, the in vivo antitendon adhesion data reveals that the lubricating nanofiber group has a significantly lower adhesion score and a better antitissue adhesion. Altogether, our developed hydration-enhanced lubricating nanofibers show promising applications in the biomedical field such as antiadhesive membranes.

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“…More recently, researchers have developed two-fluid side-by-side and coaxial electrospinning processes (resulting in Janus or core/shell fibers) [10][11][12][13][14][15][16], three-fluid triaxial electrospinning, and other more complicated experiments [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

Liu

Yang

et al. 2019

Chemical Engineering Journal

137

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ucture, and in turn its functional performance, is of crucial importance for potential applications. In this study, a new modified triaxial electrospinning process was successfully developed to allow us to precisely tune drug release from nanoscale formulations. In this process, we used two un-electrospinnable liquids as the outer and middle working fluids, with only the core solution being individually electrospinnable into fibers. The outer liquid comprised a mixture of solvents, while the middle fluid was a dilute solution of cellulose acetate (CA). The core fluid was an electrospinnable co-dissolving solution of ferulic acid (FA) and gliadin. By processing these in triaxial electrospinning, we were able to create FA-gliadin fibers coated with a thin but even and continuous coating of CA. The thickness of the CA coating could be precisely varied by adjusting the flow rate of the middle working fluid. The resultant nanofibers have linear and cylindrical morphologies with clear core-shell structures. X-ray diffraction and IR spectroscopy data verified that the fibers comprised amorphous solid dispersions, with intermolecular interactions existing between FA and gliadin. The CA coating eliminated the initial burst release seen with uncoated FA-gliadin fibers, and also led to close to zero-order release profiles which could be incrementally adjusted by varying the thickness of the coating. New process-nanostructure-performance relationships are therefore revealed, and the advanced triaxial electrospinning approach reported in this work has great potential for developing new kinds of functional nanomaterials.

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Multi-functional electrospun antibacterial core-shell nanofibrous membranes for prolonged prevention of post-surgical tendon adhesion and inflammation

Cited by 127 publications

References 64 publications

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion

Tunable zero-order drug delivery systems created by modified triaxial electrospinning

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