Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion

Abstract

<jats:p>Lubrication is the key to efficient function of human tissues and has significant impact on the comfort level. However, the construction of a lubricating nanofibrous membrane has not been reported as yet, especially using a one-step surface modification method. Here, bioinspired by the superlubrication mechanism of articular cartilage, we successfully construct hydration-enhanced lubricating nanofibers via one-step in situ grafting of a copolymer synthesized by dopamine methacrylamide (DMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) onto electrospun polycaprolactone (PCL) nanofibers. The zwitterionic MPC structure provides the nanofiber surface with hydration lubrication behavior. The coefficient of friction (COF) of the lubricating nanofibrous membrane decreases significantly and is approximately 65% less than that of pure PCL nanofibers, which are easily worn out under friction regardless of hydration. The lubricating nanofibers, however, show favorable wear-resistance performance. Besides, they possess a strong antiadhesion ability of fibroblasts compared with pure PCL nanofibers. The cell density decreases approximately 9-fold, and the cell area decreases approximately 12 times on day 7. Furthermore, the in vivo antitendon adhesion data reveals that the lubricating nanofiber group has a significantly lower adhesion score and a better antitissue adhesion. Altogether, our developed hydration-enhanced lubricating nanofibers show promising applications in the biomedical field such as antiadhesive membranes.</jats:p>

Ball‐Bearing‐Inspired Polyampholyte‐Modified Microspheres as Bio‐Lubricants Attenuate Osteoarthritis

“…[ 25 ] Inspired by this, various zwitterionic polymer brushes were used to modify different materials and have been proved to effectively reduce the friction coefficient. [ 26,27 ] As such, modification of hydrogel microspheres with zwitterionic polymer brushes can be an effective strategy to reduce surface roughness, endowing hydrogel microspheres with super‐lubrication capability. Poly sulfobetaine methacrylate (pSBMA) brush, derivatives of sulfobetaine (SB), with superhydrophilic property, has emerged as a promising zwitterionic material for manufacturing antifouling surfaces in recent years.…”

Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration

“…In the end, the fewer-layer BP nanosheets were incubated with Fmoc-BMP 2 at room temperature to generate the BP@BMP 2 via the π-p interaction or electrostatic interaction, according to a previous study. [19] Electrospun Scaffold Fabrication: Electrospinning is a robust technology to fabricate functional nanofibers, [41] and the fabrication method of the electrospun micro-sol scaffold was described previously. [42] Firstly, 1 wt% HA solution was prepared by adding 0.1 g HA to 9.9 g deionized water (DD-water), containing 1 wt% BP, BMP 2 , or BP@BMP 2 solution.…”

Black phosphorus-based 2D materials for bone therapy

“…Inspired by the super lubrication mechanism of articular cartilage, our group successfully constructed hydration super-lubricated electrospun nanofibrous membranes for the prevention of tendon adhesion. This copolymer was synthesized by grafting polydopamine methacrylamide (pDMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) onto PCL electrospun membranes in-situ via one step method [ 205 ].…”