Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides

Green Chemistry Approach to Fast and Highly Efficient One-Pot Synthesis of Bis-Isoxazolyl-1,2,5,6-Tetrahydro Pyridine-3-Carboxylates

“…Isoxazoles are potent analgesic, anti-inflammatory [16], antimicrobial [17], COX-2 inhibitory [18], antitubercular [19], anticonvulsant [20], and anticancer agents [21]. In continuation of our studies on the synthesis of biologically important heterocyclic compounds [22][23][24][25][26], in the present work we have designed the synthesis of a novel tetrahydropyridine derivatives incorporated with isoxazole moiety utilizing an eco-friendly, reusable and inexpensive ionic liquid as solvent as well as a catalyst.…”

Facile synthesis, antimicrobial, and anti‐inflammatory activities of novel isoxazolyl imidazo[1,2‐b]isoxazoles

“…Based on the bio activities of imidazole and isoxazole ring systems, we proposed to construct a system that combine these bio-labile rings together in a single molecular framework to see the additive effect toward their biological activity. As a sequel to our work on the synthesis of fused isoxazoles [21][22][23][24][25][26], we herein, wish to report the synthesis of novel isoxazolyl imidazo [1,2-b]isoxazoles and the new compounds were investigated for their in vitro antimicrobial and anti-inflammatory activities.…”

Rhodium‐Catalyzed C−H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N‐Oxides

“…The N-oxides of isoquinoline and pyridine are important structural units widely embedded in various natural products, [1] pharmaceutical agents, [2] and chiral ligands (Figure 1). [3] Meanwhile, they are also widely used as powerful directing groups in the CÀ H functionalization of isoquinolines, pyridines and other natural product scaffolds.…”