Mucosal immunisation and immunoprophylaxis as potential strategies for prevention of SARS

Foxwell, A. Ruth; Cripps, Allan W.

doi:10.1016/s0140-6736(04)16535-5

Cited by 4 publications

(5 citation statements)

References 10 publications

(13 reference statements)

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“…If SARS actually comes back we will be able to distinguish between SARS and influenza. Development of efficient specific antiviral drugs, such as human interferons [20], small interfering RNA [21], mucosal vaccine [22,23] or inactivated vaccine [24][25][26] is very important to protect the transmission of SARS-CoV.…”

Section: Discussionmentioning

confidence: 99%

Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice

Wang

Yuan

Matsumoto

et al. 2005

Biochemical and Biophysical Research Communications

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To analyze the immune responses of DNA vaccine encoded different gene fragments of severe acute respiratory syndrome coronavirus (SARS-Cov), SARS-Cov gene fragments of membrane (M), nucleocapsid (N), spike a (Sa), and spike b (Sb) proteins were cloned into pcDNA3.1 (Invitrogen) vector to form plasmids pcDNAM, pcDNAN, pcDNASa, and pcDNASb, respectively. After mice were immunized intramuscularly with pcDNAM, pcDNAN or pcDNASa-pcDNASb plasmid, blood was collected and serum was separated. Humoral immune response was detected with the enzyme-linked immunosorbent assay, and cellular immune response of SARS-Cov DNA vaccines was detected with lymphoproliferation assay and cytotoxic T lymphocyte assay. Results show that cellular and humoral immune responses can be detected after immunization with pcDNAM, pcDNAN or pcDNASa-pcDNASb plasmids in BALB/c mice. However, pcDNAM stimulated the highest cellular immune response than other plasmids, and pcDNASa-pcDNASb stimulated the highest humoral immune response in week 12. The present results not only suggest that DNA immunization with pcDNAM, pcDNAN or pcDNASa-pcDNASb could be used as potential DNA vaccination approaches to induce antibody in BALB/c mice, but also to illustrate that gene immunization with these SARS DNA vaccines different immune response characters.

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Section: Discussionmentioning

confidence: 99%

Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice

Wang

Yuan

Matsumoto

et al. 2005

Biochemical and Biophysical Research Communications

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“…At the interface between enveloped viruses and the virus−mucosal interface, the mucosal immune system defends against viruses before they can spread further within the body. 143,144 Numerous infectious viruses, including the pathogenic coronaviruses identified in the past two decades (SARS-CoV-1, MERS-CoV, and SARS-CoV-2), can survive in the respiratory and digestive tracts. 67,145,146 The skin is a natural defense system against infectious agents, such as viruses, fungi, and bacteria, through its immune responses to exogenous pathogens and physical barriers.…”

Section: Virus−host Interfacementioning

confidence: 99%

“…Touching the eyes, nose, or mouth with hands or napkins contaminated with a virus also increases the risk of mucosal infection. At the interface between enveloped viruses and the virus–mucosal interface, the mucosal immune system defends against viruses before they can spread further within the body. , Numerous infectious viruses, including the pathogenic coronaviruses identified in the past two decades (SARS-CoV-1, MERS-CoV, and SARS-CoV-2), can survive in the respiratory and digestive tracts. ,, …”

Section: Environmental Transmission Of Enveloped Virusesmentioning

confidence: 99%

Environmental Stability and Transmissibility of Enveloped Viruses at Varied Animate and Inanimate Interfaces

Zeng

et al. 2023

Environ. Health

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Enveloped viruses have been the leading causative agents of viral epidemics in the past decade, including the ongoing coronavirus disease 2019 outbreak. In epidemics caused by enveloped viruses, direct contact is a common route of infection, while indirect transmissions through the environment also contribute to the spread of the disease, although their significance remains controversial. Bridging the knowledge gap regarding the influence of interfacial interactions on the persistence of enveloped viruses in the environment reveals the transmission mechanisms when the virus undergoes mutations and prevents excessive disinfection during viral epidemics. Herein, from the perspective of the driving force, partition efficiency, and viral survivability at interfaces, we summarize the viral and environmental characteristics that affect the environmental transmission of viruses. We expect to provide insights for virus detection, environmental surveillance, and disinfection to limit the spread of severe acute respiratory syndrome coronavirus 2.

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“…However, dose-response and safety studies still need to be conducted. Moreover, studies addressing the efficacy and safety of administering neutralising antibodies to patients with established infections are outstanding (Foxwell and Cripps, 2004). Substantial functional changes were detected in spike glycoprotein of SARS-CoV isolates obtained from a SARS case in late 2003 from Guangdong province S(GD03T0013) and from two palm civets (S(SZ3), S(SZ16)).…”

Section: Antiviral Antibodiesmentioning

confidence: 99%

Development of antiviral therapy for severe acute respiratory syndrome

et al. 2005

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A new disease, the severe acute respiratory distress syndrome (SARS), caused by the SARS coronavirus (SARS-CoV), emerged at the beginning of 2003 and rapidly spread throughout the world. Although the disease had disappeared in June 2003 its re-emergence cannot be excluded. The development of vaccines against SARS-CoV may take years. Therefore, the availability of effective antiviral drugs against SARS-CoV may be crucial for the control of future SARS outbreaks. In this review, experimental and clinical data about potential anti-SARS drugs is summarised and discussed. Animal model studies will be needed to help to determine which interventions warrant controlled clinical testing.

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Mucosal immunisation and immunoprophylaxis as potential strategies for prevention of SARS

Cited by 4 publications

References 10 publications

Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice

Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice

Environmental Stability and Transmissibility of Enveloped Viruses at Varied Animate and Inanimate Interfaces

Development of antiviral therapy for severe acute respiratory syndrome

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