Mucosal immune response in newborn Holstein calves that had maternally derived antibodies and were vaccinated with an intranasal multivalent modified-live virus vaccine

Abstract

IN vaccination of newborn calves with high concentrations of virus-neutralizing antibodies increased NSS IgA titers but did not change serum antibody titers. Revaccination of group C calves on day 35 induced IgA production. Intranasal vaccination with a modified-live virus vaccine was effective in calves that had maternally derived antibodies.

Effectiveness of two intranasal vaccines for the control of bovine respiratory disease in newborn beef calves: A randomized non-inferiority multicentre field trial

“…It has been observed that many BRSV infection models failed to reproduce the severe clinical signs of the disease, complicating the evaluation of vaccine efficacy ( Belknap et al, 1995 , Blodörn et al, 2015 , Taylor, 2013 ). In these studies, efficacy was demonstrated in newborn calves both in the absence of BRSV-specific MDAs ( Ellis et al, 2007 , Vangeel et al, 2007 ) and in their presence ( Ellis et al, 2013 , Hill et al, 2012 ). However, the absence of maternal antibody interference is not always observed ( Ellis et al, 2010 ).…”

Mucosal Vaccine Development for Veterinary and Aquatic Diseases

“…To test this hypothesis, cows were vaccinated with modified live bovine viral diarrhea virus (BVDV) vaccine composed of BHV-1, BVDV-1, BVDV-2, PI-3, and BRSV antigens. Calves were shown to have high circulating maternally derived IgG antibodies serum but extremely low titers of maternally derived IgG in nasal secretions [22]. Maternally derived IgA in nasal secretions were present but at much lower levels than in serum.…”

Bovine Respiratory Disease Vaccination Against Viral Pathogens

“…Intranasal vaccination is an effective mechanism to induce local mucosal immune priming and immunoglobulin A production IFOMA. 67 Greater mucosal (nasal secretions) and systemic-specific immunity has been reported in calves vaccinated IFOMA intranasally with a MLV BRSV and/or BHV-1 vaccine versus parenteral vaccination. 68 Several studies have demonstrated efficacy of IN vaccination of calves IFOMA on protection against respiratory viruses 53,58,68 ; however, few field and experimental challenge studies have compared their efficacy to parenteral vaccines for reducing BRD morbidity or mortality.…”