Mucosal-associated invariant T cells restrict allergic airway inflammation

Background: Immune cells and immune proteins play a pivotal role in host responses to pathogens, allergens and cancer. Understanding the crosstalk between allergic response and cancer, immune surveillance, immunomodulation, role of immunoglobulin E (IgE)-mediated functions and help to develop novel therapeutic strategies. Allergy and oncology show two opposite scenarios: whereas immune tolerance is desired in allergy, it is detrimental in cancer.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…The reduction of MAIT cells in asthma patients might participate in an augmented inflammatory response to allergens. 70 …”

Section: Role Of Immune Cells In Allergy and Cancermentioning

confidence: 99%

“…Finally, MAIT cells were reduced after reiterated allergen exposure. The reduction of MAIT cells in asthma patients might participate in an augmented inflammatory response to allergens 70 …”

Section: Role Of Immune Cells In Allergy and Cancermentioning

confidence: 99%

AllergoOncology: Role of immune cells and immune proteins

Gioacchino

Valle

Allegra

et al. 2022

Clinical & Translational All

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“…Adult asthmatics have reduced frequencies of circulating and airway MAIT cells, again implicating them in limiting disease (Hinks et al, 2015). Sustained exposure of mice to aero-allergens such as HDM or Alternaria results in a rapid, IL-4-dependent decrease in pulmonary MAIT cell frequency (Ye et al, 2020), and proliferation of human MAIT cells is inhibited by IL-4, a process alleviated by IFN-g. Interestingly, MAIT cell-deficient mice have enhanced ILC2 responses during Alternaria sensitization and appear to be capable of suppressing ILC2s through production of IL-4-induced 1 (IL4I1), an L-phenylalanine oxidase (Ye et al, 2020). Unlike MAIT cells, which primarily secrete type 1 cytokines, NK T cells can secrete a plethora of cytokines upon activation, and airway glycolipid exposure results in NK T cell-dependent type 2 inflammation.…”

Section: Know Your Neighbors: Community Interactions Between Innate and Invariant Resident Pulmonary Lymphoid Cellsmentioning

confidence: 99%

Overlapping and distinct features of viral and allergen immunity in the human lung

Harker

Lloyd

2021

Immunity

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“…One study has shown that there is a positive correlation between activated NK cells, innate lymphoid cells (ILCs) and MAIT cells, and a negative correlation with forced expiratory volume in the first second (FEV1), which may be associated with airflow limitation in patients with asthma [79] . However, in an animal model, Ye et al [84] found that the number of lung-resident MAIT cells was decreased significantly in C57BL/6 mice with repeated intranasal exposure to various common allergens including extracts from Aspergillus , Alternaria , house dust mite and cockroach, and none of these mice were treated with corticosteroids. MR1 −/− mice lacking MAIT cells aggravated ILC2 response, and increased airway inflammation and AHR with inhalation of Alternaria , while adoptive transfer of MAIT cells inhibited ILC2 response and reduced airway inflammation and AHR.…”

Section: Mait Cells In Lung Diseasesmentioning

confidence: 99%

Title of article: Mucosal-associated invariant T cells in lung diseases

Wen

Zhang

Nian

et al. 2021

International Immunopharmacology

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The lungs are directly connected to the external environment, which makes them more vulnerable to infection and injury. They are protected by the respiratory epithelium and immune cells to maintain a dynamic balance. Both innate and adaptive immune cells are involved in the pathogenesis of lung diseases. Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells, which have attracted increasing attention in recent years. Although MAIT cells account for a small part of the total immune cells in the lungs, evidence suggests that these cells are activated by T cell receptors and/or cytokine receptors and mediate immune response. They play an important role in immunosurveillance and immunity against microbial infection, and recent studies have shown that subsets of MAIT cells play a role in promoting pulmonary inflammation. Emerging data indicate that MAIT cells are involved in the immune response against SARS-CoV-2 and possible immunopathogenesis in COVID-19. Here, we introduce MAIT cell biology to clarify their role in the immune response. Then we review MAIT cells in human and murine lung diseases, including asthma, chronic obstructive pulmonary disease, pneumonia, pulmonary tuberculosis and lung cancer, and discuss their possible protective and pathological effects. MAIT cells represent an attractive marker and potential therapeutic target for disease progression, thus providing new strategies for the treatment of lung diseases.

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Mucosal-associated invariant T cells restrict allergic airway inflammation

Cited by 26 publications

References 14 publications

AllergoOncology: Role of immune cells and immune proteins

AllergoOncology: Role of immune cells and immune proteins

Overlapping and distinct features of viral and allergen immunity in the human lung

Title of article: Mucosal-associated invariant T cells in lung diseases

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