AllergoOncology: Role of immune cells and immune proteins

Gioacchino, Mario Di; Valle, Loredana Della; Allegra, Alessandro; Pioggia, Giovanni; Gangemi, Sebastiano

doi:10.1002/clt2.12133

Cited by 7 publications

(3 citation statements)

References 177 publications

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“…TNF-α can stimulate the proliferation of B cells, promote the secretion of Ig, and promote the release of inflammatory factors. TNF-α can affect the body's anti-infection ability, and the more severe the viral infection or bacterial infection, the higher the level of TNF-α [33,34].…”

Section: Computational and Mathematical Methods In Medicinementioning

confidence: 99%

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Zhang

Guo

et al. 2022

Computational and Mathematical Methods in Medicine

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Aims. To investigate the effect of Vitapex combined with AH-plus paste on inflammation in middle-aged and elderly patients with periodontal-endodontic disease. Materials and Methods. A total of 80 teeth of middle-aged and elderly patients with the periodontal-endodontic disease who were treated in our hospital from June 2020 to June 2021 were selected as the research objects and were divided into comparison group and treatment group with 40 teeth each according to different treatment methods. Among them, the comparison group was filled with zinc oxide clove oil paste gutta-percha, and the treatment group was filled with Vitapex combined with AH-plus paste. The changes in apical cross-section sealing performance, periodontal pocket depth (PD), and gingival index (GI) of the two groups before treatment and after 6 months of follow-up were observed and compared, and X-ray analysis was performed. Results. There was no significant difference in the level of periodontal indexes and serum inflammatory indexes between the two groups before treatment ( P > 0.05 ). After treatment, the levels of PD, BI, PLI, and GI in the two groups were significantly lower than before treatment ( P < 0.05 ). The differences in IL-6, IL-10, TNF-α, and IL-1β after treatment were significant ( P < 0.05 ). There was no significant difference in the root canal area data of each cross-section between the two groups when the root canal was filled with root filling paste at different positions from the apex ( P > 0.05 ). After root canal filling with root canal paste, the cross-sectional area from different parts of the root canal in the treatment group was significantly smaller than comparison group ( P < 0.05 ). After 6 months of treatment, it was found that CEJ-BD and CEJ-AC in the treatment group were significantly lower than those in the comparison group ( P < 0.05 ). Conclusion. Vitapex combined with AH-plus paste filling can effectively treat middle-aged and elderly periodontal-endodontic disease, which provides a certain reference for the clinical treatment of middle-aged and elderly periodontal-endodontic disease.

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Section: Computational and Mathematical Methods In Medicinementioning

confidence: 99%

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Zhang

Guo

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Although still controversial, most studies point out an antitumorigenic role of eosinophils mediated by α-defensins, TNFα, granzyme A, and IL-18, while in a few others, they are innocent bystanders or their presence in the tumor microenvironment have been linked to poor prognosis. 2,3 Furthermore, eosinophils have been proposed to be potential end-stage effector cells in cancer immunotherapy. 3 Biological agents which antagonize IL-5 or IL-5R may lead to a reduction in peripheral blood eosinophil counts.…”

Section: Real-worldevidenceontheriskofcancerwithanti-il-5and Anti-il-...mentioning

confidence: 99%

Real‐world evidence on the risk of cancer with anti‐IL‐5 and anti‐IL‐4Ra biologicals

Mota

Rama

Moreira

2023

Allergy

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“…In laryngeal carcinoma, TGF-β regulates cells of the innate and adaptive immune system [ 45 ]. Upon exposure to TGF-β, the primary antigen-presenting cells, the dendritic cells, facilitate immune tolerance and become inactive and immobile [ 46 ]. Moreover, TGF-β skews T-naïve lymphocytes’ differentiation towards T-regulatory lymphocytes (T-regs) instead of the immune-potent Th1 lymphocytes [ 45 ].…”

Section: Epithelial-to-mesenchymal Transition (Emt)mentioning

confidence: 99%

Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma

Goulioumis

Gyftopoulos²

2022

Biomedicines

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In epithelial neoplasms, such as laryngeal carcinoma, the survival indexes deteriorate abruptly when the tumor becomes metastatic. A molecular phenomenon that normally appears during embryogenesis, epithelial-to-mesenchymal transition (EMT), is reactivated at the initial stage of metastasis when tumor cells invade the adjacent stroma. The hallmarks of this phenomenon are the abolishment of the epithelial and acquisition of mesenchymal traits by tumor cells which enhance their migratory capacity. EMT signaling is mediated by complex molecular pathways that regulate the expression of crucial molecules contributing to the tumor’s metastatic potential. Effectors of EMT include loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, neovascularization, acquisition of stem-cell properties, and the activation of tumor stroma. However, the current approach to EMT involves a holistic model that incorporates the acquisition of potentials beyond mesenchymal transition. As EMT is inevitably associated with a reverse mesenchymal-to-epithelial transition (MET), a model of partial EMT is currently accepted, signifying the cell plasticity associated with invasion and metastasis. In this review, we identify the cumulative evidence which suggests that various aspects of EMT theory apply to laryngeal carcinoma, a tumor of significant morbidity and mortality, introducing novel molecular targets with prognostic and therapeutic potential.

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AllergoOncology: Role of immune cells and immune proteins

Cited by 7 publications

References 177 publications

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease

Real‐world evidence on the risk of cancer with anti‐IL‐5 and anti‐IL‐4Ra biologicals

Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma

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