Mucocutaneous lupus erythematosus in dogs (21 cases)

Olivry, Thierry; Rossi, Michael; Banović, Frane; Linder, Keith E.

doi:10.1111/vde.12217

Cited by 30 publications

(80 citation statements)

References 26 publications

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“…Basal cell apoptosis in combination with a generic mucosal lichenoid inflammatory pattern might lead to a misdiagnosis of mucocutaneous lupus erythematosus (MCLE), which shares clinical features with MMP including a propensity to form mucocutaneous ulcers and a breed predisposition for the German shepherd dog. Mucocutaneous lupus erythematosus, however, rarely affects the oral cavity . It is possible that some dogs develop both conditions concurrently, because we have observed one case with good histological evidence of both MCLE and MMP .…”

Section: Discussioncontrasting

confidence: 64%

“…Mucocutaneous lupus erythematosus, however, rarely affects the oral cavity . It is possible that some dogs develop both conditions concurrently, because we have observed one case with good histological evidence of both MCLE and MMP . Suprabasal apoptosis of keratinocytes might lead to a histological misdiagnosis of the erythema multiforme (EM) group of diseases, but usually EM presents with more suprabasal apoptosis than that observed in this study .…”

Section: Discussioncontrasting

confidence: 64%

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Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases

Tham

Olivry

Linder

et al. 2016

Veterinary Dermatology

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Section: Discussioncontrasting

confidence: 64%

Section: Discussioncontrasting

confidence: 64%

Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases

Tham

Olivry

Linder

et al. 2016

Veterinary Dermatology

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“…At this time, well characterized manifestations of canine CLE that fall under the category of CCLE include the long recognized, localized, facial‐predominant DLE, exfoliative CLE (ECLE) of German shorthaired pointers and mucocutaneous lupus erythematosus (MCLE) . Several single case reports have suggested the existence of other generalized variants of CCLE in dogs …”

Section: Introductionmentioning

confidence: 99%

Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases)

Banović

Linder

Uri

et al. 2016

Veterinary Dermatology

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Background -Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized.Hypothesis/Objectives -We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE.Methods -Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis). Direct immunofluorescence (IF) and antinuclear antibody serology were investigated whenever possible.Results -Various breeds were affected in their mid-to late adulthood. Selection criteria of generalized multifocal, annular ("discoid") to polycyclic plaques with pigment changes, erythematous margin, adherent scaling, follicular plugging and central alopecia were shown in all dogs. In nine dogs, plaques contained mild to moderate central scarring with depigmentation and/or hyperpigmentation. There were no dogs in which the disease progressed to systemic lupus erythematosus within a median follow-up of 2.5 years. Per inclusion criteria, interface dermatitis occurred with basement membrane zone (BMZ) thickening, suprabasal apoptosis and/or dermal fibrosis in some dogs. Infundibular interface folliculitis was common; it sometimes transitioned to mural folliculitis in lower follicle segments, and occurred with follicular and sebaceous gland atrophy. The direct IF revealed patchy deposition of immunoglobulin IgG and IgM at the BMZ. Lesions responded to a variety of treatments, including ciclosporin, hydroxychloroquine, topical tacrolimus and tetracycline/niacinamide. Relapses were common after medications were tapered.Conclusions and clinical importance -These observations support the existence of a canine homologue of human GDLE.

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“…These differences could be due to the diverse pathogenesis of this distinct lupus‐type or, more likely, the mucocutaneous location of the lesions, typically associated with a plasma cell‐predominant infiltrate in this study . In a study describing a mucocutaneous variant of DLE, plasma cells also predominated in the superficial dermis …”

Section: Discussionmentioning

confidence: 79%