Mucoadhesive hydrogels for buccal drug delivery: In vitro-in vivo correlation study

Baus, Randi Angela; Zahir‐Jouzdani, Forouhe; Dünnhaupt, Sarah; Atyabi, Fatemeh; Bernkop‐Schnürch, Andreas

doi:10.1016/j.ejpb.2019.07.019

Cited by 52 publications

(29 citation statements)

References 41 publications

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“…Hydrogels based on HEC, CMC, hyaluronic acid (HA), sodium alginate, xanthan, carbopol, as well as polycarbophil and porcine mucus were ex vivo studied, in order to establish the resistance to removal by the flow of artificial saliva. An increase of the residence time was observed as follows: carbopol < hydroxyethyl cellulose, hyaluronic acid, alginate, polycarbophil < carboxymethyl cellulose < xanthan [101].…”

Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 95%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

122

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 95%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

122

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“…The non-thixotropic behavior indicated a time-independent flow; a property that helps the retention of gels on the eye. The thixotropic behavior indicated a time-dependent flow that requires enough time to reform again application [73]. From the power law, the flow index (n) values were <1 revealing a non-Newtonian shear thinning behavior.…”

Section: Evaluation Of Rheological Properties Of the Prepared Acz Andmentioning

confidence: 99%

Formulation and Characterization of Acetazolamide/Carvedilol Niosomal Gel for Glaucoma Treatment: In Vitro, and In Vivo Study

Abdelmonem¹,

Elhabal²,

Abdelmalak³

et al. 2021

Pharmaceutics

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Acetazolamide (ACZ) is a diuretic used in glaucoma treatment; it has many side effects. Carvedilol (CAR) is a non-cardioselective beta-blocker used in the treatment of elevated intraocular pressure; it is subjected to the first-pass metabolism and causes fluids accumulation leading to edema. This study focuses on overcoming previous side effects by using a topical formula of a combination of the two previous drugs. Sixty formulations of niosomes containing Span 20, Span 60, Tween 20, and Tween 60 with two different ratios were prepared and characterized. Formulation with the lowest particle size (416.30 ± 0.23), the highest zeta potential (72.04 ± 0.43 mv), and the highest apparent coefficient of corneal permeability (0.02 ± 0.29 cm/h) were selected. The selected formula was incorporated into the gel using factorial design 23. Niosomes (acetazolamide/carvedilol) consisting of Span 60 and cholesterol in the molar ratio (7:6), HMPC, and carbopol with two different ratios were used. The selected formula was subjected to an in vivo study of intraocular pressure in ocular hypertensive rabbits for 60 h. The sustained gel formula of the combination decreased (IOP) to normal after 1 h and sustained efficacy for 4 days. Histological analysis of rabbit eyeballs treated with the selected formula showed improvement in glaucomatous eye retinal atrophy.

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“…Effective treatment of xerostomia, therefore, includes not only the stimulation of saliva but also an improvement of its composition. Polysaccharides such as carboxymethyl cellulose and hyaluronic acid are well known for improving mucoadhesion [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Effect of a newly developed pastille on the salivary flow rate in subjects with dry mouth symptoms: a randomized, controlled, monocentric clinical study

et al. 2021

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Background Xerostomia is associated with several diseases and is a side effect of certain drugs, resulting from reduced saliva secretion. Often, aged and sometimes younger people suffer from (idiopathic) xerostomia. Chewing gum and sucking pastilles may relieve symptoms of xerostomia by increasing the salivary flow rate due to the mechanical effect of sucking and gustatory stimulation. Swallowing problems and the urge to cough or experiencing a tickling sensation in the throat might be alleviated through a reduction in dry mouth symptoms. We investigated whether a pastille containing four polysaccharides increased the salivary flow rate and relieved the symptoms of dry mouth. Methods Participating subjects with xerostomia were randomized into two equally balanced treatment groups. Subjects received the pastille on Day 1 and a control product (Parafilm®) on Day 3, or vice versa. Unstimulated saliva was collected every 2.5 min for 0–10 min. Stimulated saliva was collected after subjects sucked the pastille or the control product. The salivary flow rate was determined gravimetrically, and, in parallel, the feeling of dry mouth was assessed using a visual analog scale. Saliva surface tension was measured in pooled saliva samples (0–5 min of sampling). Additionally, in stimulated saliva from six subjects who sucked the pastille, the presence of the main ingredient—gum arabic—was examined by Raman spectroscopy. Results Chewing the pastille significantly increased the mean salivary flow rate by 8.03 g/10 min compared to the mean changes after chewing the control product (+ 3.71 g/10 min; p < 0.0001). The mean score of dry mouth was significantly alleviated by the pastille (− 19.9 ± 17.9 mm) compared to the control product (− 3.3 ± 18.1 mm). No difference between the two products was seen regarding the saliva surface tension. Gum arabic was present in the saliva of all investigated subjects for up to 10 min after sucking the pastille. Conclusions The pastille was well tolerated and effective in increasing the salivary flow rate and reducing mouth dryness after sucking. These results were in line with the detection of the main ingredient, gum arabic, in saliva for up to 10 min after sucking the pastille. Trial registration German Register Clinical Trials (Deutsches Register Klinische Studien, DRKS) DRKS-ID: DRKS00017393, Registered 29 May 2019, https://www.drks.de/drks_web/navigate.do?navigationId=trial. HTML&TRIAL_ID = DRKS00017393.

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Mucoadhesive hydrogels for buccal drug delivery: In vitro-in vivo correlation study

Cited by 52 publications

References 41 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Formulation and Characterization of Acetazolamide/Carvedilol Niosomal Gel for Glaucoma Treatment: In Vitro, and In Vivo Study

Effect of a newly developed pastille on the salivary flow rate in subjects with dry mouth symptoms: a randomized, controlled, monocentric clinical study

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