Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu, Diana; Nicu, Raluca; Ciolacu, Florin

doi:10.3390/ma13225270

Cited by 122 publications

(104 citation statements)

References 135 publications

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“…The rheogram of the plain HPC hydrogel (G4) shows very insignificant hysteresis in the rheogram. This behavior-the negligible hysteresis of HPC hydrogels-has already been reported [40]. Meanwhile, the hysteresis area was found to be slightly increased in the NEG1 sample.…”

Section: Rheological Evaluation Of the Hpc Hydrogel Loaded With Optimized Co-ne (Neg1)supporting

confidence: 84%

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

et al. 2021

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Oral health is a key contributor to a person’s overall health and well-being. Oral microbiota can pose a serious threat to oral health. Thus, the present study aimed to develop a cinnamon oil (CO)-loaded nanoemulsion gel (NEG1) to enhance the solubilization of oil within the oral cavity, which will enhance its antibacterial, antifungal, and analgesic actions against oral microbiota. For this purpose, the CO-loaded nanoemulsion (CO-NE) was optimized using I-optimal response surface design. A mixture of Pluracare L44 and PlurolOleique CC 497 was used as the surfactant and Capryol was used as the co-surfactant. The optimized CO-NE had a globule size of 92 ± 3 nm, stability index of 95% ± 2%, and a zone of inhibition of 23 ± 1.5 mm. This optimized CO-NE formulation was converted into NEG1 using 2.5% hydroxypropyl cellulose as the gelling agent. The rheological characterizations revealed that the NEG1 formulation exhibited pseudoplastic behavior. The in vitro release of eugenol (the marker molecule for CO) from NEG1 showed an enhanced release compared with that of pure CO. The ex vivo mucosal permeation was found to be highest for NEG1 compared to the aqueous dispersion of CO-NE and pure cinnamon oil. The latency reaction time during the hot-plate test in rats was highest (45 min) for the NEG1 sample at all-time points compared with those of the other tested formulations. The results showed that the CO-NEG formulation could be beneficial in enhancing the actions of CO against oral microbiota, as well as relieving pain and improving overall oral health.

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Section: Rheological Evaluation Of the Hpc Hydrogel Loaded With Optimized Co-ne (Neg1)supporting

confidence: 84%

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

et al. 2021

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“…Alginate is also FDA approved and often used in drug- and protein-delivery systems and for wound healing treatments [ 89 ]. Cellulose is one of the most abundant biodegradable materials in nature, and has been widely used in medical applications such as wound dressing [ 90 ], tissue engineering [ 91 ], controllable drug delivery system [ 92 ], treatments [ 93 , 94 ], and as a excipient in the pharmaceutical industry. Poly(ethylene glycol) (PEG), poly(ε-caprolactone) (PCL), and poly(lactide-co-glycolide) (PLGA) are synthetic polymers that have been investigated in clinical trials and approved by the FDA for safe use in humans.…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

et al. 2021

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The limited penetration depth of visible light in biological tissues has encouraged researchers to develop novel implantable light-guiding devices. Optical fibers and waveguides that are made from biocompatible and biodegradable materials offer a straightforward but effective approach to overcome this issue. In the last decade, various optically transparent biomaterials, as well as different fabrication techniques, have been investigated for this purpose, and in view of obtaining fully fledged optical fibers. This article reviews the state-of-the-art in the development of biocompatible and biodegradable optical fibers. Whilst several reviews that focus on the chemical properties of the biomaterials from which these optical waveguides can be made have been published, a systematic review about the actual optical fibers made from these materials and the different fabrication processes is not available yet. This prompted us to investigate the essential properties of these biomaterials, in view of fabricating optical fibers, and in particular to look into the issues related to fabrication techniques, and also to discuss the challenges in the use and operation of these optical fibers. We close our review with a summary and an outline of the applications that may benefit from these novel optical waveguides.

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“…The amphiphilic nature of chemically modified polysaccharides causes their adsorption at the interface of oil and aqueous solvents that results in the stabilization of the emulsion [269]. This property of polysaccharides proved highly beneficial for the delivery of lipophilic or non-polar therapeutics at their target site [270].…”

Section: Polysaccharides As Emulsion Stabilizersmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cited by 122 publications

References 135 publications

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

Current-status and applications of polysaccharides in drug delivery systems

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