Mucoadhesive film for anchoring assistive surgical instruments in endoscopic surgery: in vivo assessment of deployment and attachment

Valdastri, Pietro; Tognarelli, Selene; Menciassi, Arianna; Arezzo, Alberto; Dario, P.

doi:10.1007/s00464-011-1672-7

Cited by 10 publications

(3 citation statements)

References 24 publications

(30 reference statements)

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“…Numerous studies have exploited mucoadhesion further by developing mucoadhesives to chemically bond to the mucosa to improve traction and/or adhesion. This can result in significantly higher adhesive forces while, in some cases, maintaining the ability to repeatedly reattach to the mucosa [151][152][153][154].…”

Section: Adhesionmentioning

confidence: 99%

Fundamentals of the gut for capsule engineers

et al. 2020

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The gastrointestinal (GI) tract is a complex environment comprised of the mouth, esophagus, stomach, small and large intestines, rectum and anus, which all cooperate to form the complete working GI system. Access to the GI using endoscopy has been augmented over the past several decades by swallowable diagnostic electromechanical devices, such as pill cameras.Research continues today and into the foreseeable future on new and more capable miniature devices for the purposes of systemic drug delivery, therapy, tissue biopsy, microbiome sampling, and a host of other novel ground-breaking applications. The purpose of this review is to provide engineers in this field a comprehensive reference manual of the GI environment and its complex physical, biological, and chemical characteristics so they can more quickly understand the constraints and challenges associated with developing devices for the GI space. To accomplish this, the work reviews and summarizes a broad spectrum of literature covering the main anatomical and physiological properties of the GI tract that are pertinent to successful development and operation of an electromechanical device. Each organ in the GI is discussed in this context, including the main mechanisms of digestion, chemical and mechanical processes that could impact devices, and GI motor behavior and resultant forces that may be experienced by objects as they move through the environment of the gut.

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Section: Adhesionmentioning

confidence: 99%

Fundamentals of the gut for capsule engineers

et al. 2020

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“…Dodou et al have shown that high static friction could be created between a colonoscopic device and the GI wall due to mucoadhesion (Dodou et al 2006;Dodou et al 2005). In the work of Paolo Dario et al (Pensabene et al 2011;Quaglia et al 2013), mucoadhesive patches have been tested and assembled with a release mechanism in the CEs. Additionally, it has been shown that with 5 N preload force, 110 min stable anchoring could be achieved for a 10 mm diameter mucoadhesive patch.…”

Section: Introductionmentioning

confidence: 97%

A bio-inspired attachment mechanism for long-term adhesion to the small intestine

Xie

Kothari

Terry

2015

Biomed Microdevices

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To achieve long-term attachment of capsule endoscopes (CEs) and miniature biosensors in the human gastrointestinal (GI) tract, a tissue attachment mechanism (TAM) was designed, optimized and tested for safety and adhesive capabilities on excised tissue in vitro and in vivo on a live pig model. Six TAMs were tested for their attachment strength in an in vitro attachment tensile experiment in which each TAM was tested on three different proximal intestine tissue samples. The maximum strength and average value are 8.09 N and 4.54 N respectively. The initial attachment damage was tested for 10 min using a sine wave pull force on the TAM with a 0.4 N peak value and 6 s period, which represents typical human intestinal traction force from peristalsis. The in vitro attachment tensile test verified that the tissue was not visually damaged nor perforated by the attachment process. In the in vivo experiment, four TAMs were placed in the intestine of a pig through individual longitudinal enterotomies. X-ray images were taken each hour after the surgery and showed zero migration of the TAMs after 24 h of adhesion. X-ray images taken each day indicated the attachment duration of this mechanism lasted up to 6 days. Post experiment inspection confirmed the attachment did not cause visible damage to tissue. These results confirmed the reliability of the TAM in vivo and demonstrated preliminary feasibility of long-term sensor adhesion to the GI tract.

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“…Localized drug delivery was achieved by magnetic retention under biplane fluoroscopy in a study by Laulicht et al (122), in which a drug-loaded magnetic capsule was held in a specific position of the GI tract. A future prospect for drug delivery over time is the use of mucoadhesives to stably attach the capsule to a desired point in the GI tract without the need for magnetic fields, as suggested by Pensabene et al (128). This adhesive technology is reversible, and detachment occurs after a certain time that can be trimmed by adjusting the polymer formulation.…”

Section: Therapy Deliverymentioning

confidence: 99%

Advanced Technologies for Gastrointestinal Endoscopy

Valdastri

Simi

Webster

2012

Annu. Rev. Biomed. Eng.

176

110

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The gastrointestinal tract is home to some of the most deadly human diseases. Exacerbating the problem is the difficulty of accessing it for diagnosis or intervention and the concomitant patient discomfort. Flexible endoscopy has established itself as the method of choice and its diagnostic accuracy is high, but there remain technical limitations in modern scopes, and the procedure is poorly tolerated by patients, leading to low rates of compliance with screening guidelines. Although advancement in clinical endoscope design has been slow in recent years, a critical mass of enabling technologies is now paving the way for the next generation of gastrointestinal endoscopes. This review describes current endoscopes and provides an overview of innovative flexible scopes and wireless capsules that can enable painless endoscopy and/or enhanced diagnostic and therapeutic capabilities. We provide a perspective on the potential of these new technologies to address the limitations of current endoscopes in mass cancer screening and other contexts and thus to save many lives. Review in Advance first posted online on May 29, 2012. (Changes may still occur before final publication online and in print.) Changes may still occur before final publication online and in print

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Mucoadhesive film for anchoring assistive surgical instruments in endoscopic surgery: in vivo assessment of deployment and attachment

Abstract: Mucoadhesive anchoring represents a completely biocompatible and safe solution for stable positioning of AISI onto mucosal tissue. This novel polymeric mechanism can be useful for designing intraluminal accessories and tools that enhance surgeons' performances in endoluminal procedures.

Cited by 10 publications

References 24 publications

Fundamentals of the gut for capsule engineers

Fundamentals of the gut for capsule engineers

A bio-inspired attachment mechanism for long-term adhesion to the small intestine

Advanced Technologies for Gastrointestinal Endoscopy

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