2020
DOI: 10.1088/2516-1091/abab4c
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Fundamentals of the gut for capsule engineers

Abstract: The gastrointestinal (GI) tract is a complex environment comprised of the mouth, esophagus, stomach, small and large intestines, rectum and anus, which all cooperate to form the complete working GI system. Access to the GI using endoscopy has been augmented over the past several decades by swallowable diagnostic electromechanical devices, such as pill cameras.Research continues today and into the foreseeable future on new and more capable miniature devices for the purposes of systemic drug delivery, therapy, t… Show more

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Cited by 28 publications
(20 citation statements)
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References 167 publications
(277 reference statements)
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“…In Figure 4 a, the stress–strain curve of the porcine intestine is reported; from this curve, we obtained the data of elastic modulus (0.1 MPa) and tensile strength (1.25 × 10 −2 MPa) that were in agreement with those reported by Barducci et al [ 22 ]. Moreover, Figure 4 b shows the mold used to prepare the samples and the image of the obtained hollow cylinder.…”
Section: Resultssupporting
confidence: 87%
“…In Figure 4 a, the stress–strain curve of the porcine intestine is reported; from this curve, we obtained the data of elastic modulus (0.1 MPa) and tensile strength (1.25 × 10 −2 MPa) that were in agreement with those reported by Barducci et al [ 22 ]. Moreover, Figure 4 b shows the mold used to prepare the samples and the image of the obtained hollow cylinder.…”
Section: Resultssupporting
confidence: 87%
“…Similarly, the dissolution time has to be correlated to the mechanical properties. For our experiments, we consider the transit time as the time that the food takes to reach the large and small intestine, and it was estimated that the gastric time was between 35.5 min and 57 min, while the transit time for the small intestine was about 261 min [ 39 , 40 ]. The pH-dependent dissolution appearance and data of samples are reported in Figure 5 a,b.…”
Section: Resultsmentioning
confidence: 99%
“…Increasing smart pill functionality to incorporate navigation, multiple diagnostic or therapeutic modalities, and localisation, coupled with design constraints to ensure ease of ingestion and safety [205], will bring new challenges. For example, greater systems integration brings the risk of power consumption will be especially challenging since batteries currently take up a large amount of space in capsule endoscopes.…”
Section: Future Directions Of Smart Pillsmentioning
confidence: 99%