Mucinous nevus

Rongioletti, Franco

doi:10.1001/archderm.132.12.1522

Cited by 11 publications

(9 citation statements)

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“…Mucinous nevus is an uncommon entity initially described by Redondo Bellón et al 1 in 1993 and classified as either a cutaneous mucinosis or a connective tissue nevus 1 2 . The cutaneous mucinoses are a heterogeneous group of diseases in which abnormal amounts of mucin are deposited in the skin 6 .…”

Section: Discussionmentioning

confidence: 99%

“…The cutaneous mucinoses are a heterogeneous group of diseases in which abnormal amounts of mucin are deposited in the skin 6 . Connective tissue nevi are hamartomas with unusual levels (excesses or deficiencies) of collagen, elastin, and/or proteoglycans 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Mucinous nevus is a rare disorder classified as either a cutaneous mucinosis or a connective tissue nevus 1 2 . The condition was first described by Redondo Bellón et al 1 in 1993.…”

Section: Introductionmentioning

confidence: 99%

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Mucinous Nevus

et al. 2018

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Mucinous nevus is an uncommon entity classified as either a cutaneous mucinosis or a connective tissue nevus. The condition presents as grouped papules and coalescent plaques growing in a unilateral or zosteriform manner. The key histopathological feature is a band-like deposition of mucin in the superficial dermis. A 34-year-old male presented with grouped gray-brown papules and confluent plaques exhibiting a zosteriform distribution on the right side of the lower back. The lesions had commenced in childhood. Histological examination revealed mucin deposition in the papillary dermis. Thus, we diagnosed a mucinous nevus. To date, only a few reports of such nevi have been reported in the literature. Therefore we report a rare case of mucinous nevus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mucinous Nevus

et al. 2018

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“…Histologically, two types of MN exist: connective tissue nevus of the proteoglycan (CTNP), and the combined epidermal connective tissue nevus of the proteoglycan. CTNP is classified by the presence of dermal mucin whereas combined epidermal nevus of the proteoglycan has features consistent with epidermal nevi, hyperkeratosis, elongation of rete ridges, and an acanthotic epidermis [ 3 ]. A case has been reported of combined epidermal CTNP, with mature adipocytes within the superficial dermis that was misdiagnosed as nevus lipomatosis superficialis indicating the importance of Alcian blue staining in suspicious lesions [ 4 ].…”

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confidence: 99%

An asymptomatic cluster of violaceous papules

Yaghoobi

Lal

Feily

2015

Dermatol Pract Concept

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“…This notion, however, should be toned down since mucin may be present in distinct melanocytic lesions. Indeed, following the first description of mucin depositions in neural differentiated naevi by Maize and Ackerman in 1987 1 this phenomenon was repeatedly observed 2,3,4,5. Especially in blue naevi mucin deposition is a peculiar observation.…”

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confidence: 86%

Sclerosing ‘Mucinous’ Blue Nevus: A Clinical Simulator of Dermatofibroma

Vetter-Kauczok

Becker

Bröcker

2008

Clinical medicine. Pathology

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Abundant mucin deposition is an unusual fi nding for melanocytic lesions. This notion, however, should be toned down since mucin may be present in distinct melanocytic lesions. Indeed, following the fi rst description of mucin depositions in neural differentiated naevi by Maize and Ackerman in 1987 1 this phenomenon was repeatedly observed. 2,3,4,5 Especially in blue naevi mucin deposition is a peculiar observation. For blue naevi 5 variants are distinguished to avoid the misdiagnosis of melanoma with stromal mucin deposition 6 : (i) neural nevus, (ii) myxoid intradermal nevus, (iii) alveolar cellular blue nevus, (iiii) ancient melanocytic nevus, (v) sclerosing blue nevus.In 2003, Rongioletti and Innocenzi described the fi rst two examples of sclerosing blue naevi with an abundant mucinous stroma. Herein, we describe the third case of this rare entity. It should be noted, that particularly this uncommon variant of a blue naevus is easily mistaken as desmoplastic-neurotropic melanoma in which the present stromal deposition of mucin is a more typical fi nding.A specimen from the right lower leg of a 53-year old man was referred to our dermatopathology department with the clinical diagnosis of a dermatofi broma. Clinically, the tumor appeared as a brown lesion with a regular and sharp border.The histopathological work up revealed a symmetrical, well circumscribed papule; the fi bro-mucinous stroma contained spindle-shaped and dendritic melanocytes, which sometimes were arranged in whorls (Fig. 1A). Orderly arranged melanocytes in the periphery were characterized by pigmentation, as confi rmed by melanin-staining. Melanophages were present as clearly seen in the reaction against CD68. Alcian blue staining confi rmed the mucin deposition within the tumor and excluded an intradermal component (Fig. 1B). Immunohistochemical staining with Mart-1 (Fig. 1D) and S-100 confi rmed both the nature and the distribution of the melanocytes. Notably no reaction was found against MIB-1 excluding a high proliferation rate (Fig. 1C). Thus all criteria for the diagnosis of a sclerosing mucinous blue naevus were fulfi lled, and the differential diagnosis of a malignant melanoma was excluded. Moreover, the clinical diagnosis of a dermatofi broma was ruled out by lack of either epidermal changes or typical infi ltrating pattern. Hemosiderin deposits which mimic melanin were excluded by special staining.The cause of mucin deposition in melanocytic lesions remains elusive. It was attributed to a partial involution of the respective lesions. Interestingly, the dermoscopy of the presented sclerotic blue nevus revealed a hypopigmented center; a notion which has been described before. 7 In line with this hypothesis it is well established that cellularity of naevi decrease which age, whereupon melanocytes are replaced by fi brous matrix, mucin and sometimes fat. With the present case report we like to raise the awareness for this rare entity because of the momentous differential diagnosis. Further reports of such cases would help to learn more...

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Mucinous nevus

Cited by 11 publications

References 0 publications

Mucinous Nevus

Mucinous Nevus

An asymptomatic cluster of violaceous papules

Sclerosing ‘Mucinous’ Blue Nevus: A Clinical Simulator of Dermatofibroma

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