MRSA Keratitis and Conjunctivitis: What Does It Mean Practically?

Thareja, Tarika; Kowalski, Regis P.; Jhanji, Vishal; Kamyar, Roheena; Dhaliwal, Deepinder K.

doi:10.1007/s40135-019-00206-z

Cited by 7 publications

(11 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[90] Culturedirected administration of antimicrobials, effective dosing, considering the local resistance patterns, and appropriate antiseptic strategies should be applied to restrict the spread of MRSA conjunctivitis. [91]…”

Section: Methicillin-resistant S Aureus Conjunctivitismentioning

confidence: 99%

Conjunctivitis: A Systematic Review

Azari

Arabi

2020

JOVR

View full text Add to dashboard Cite

Conjunctivitis is a commonly encountered condition in ophthalmology clinics throughout the world. In the management of suspected cases of conjunctivitis, alarming signs for more serious intraocular conditions, such as severe pain, decreased vision, and painful pupillary reaction, must be considered. Additionally, a thorough medical and ophthalmic history should be obtained and a thorough physical examination should be done in patients with atypical findings and chronic course. Concurrent physical exam findings with relevant history may reveal the presence of a systemic condition with involvement of the conjunctiva. Viral conjunctivitis remains to be the most common overall cause of conjunctivitis. Bacterial conjunctivitis is encountered less frequently and it is the second most common cause of infectious conjunctivitis. Allergic conjunctivitis is encountered in nearly half of the population and the findings include itching, mucoid discharge, chemosis, and eyelid edema. Long-term usage of eye drops with preservatives in a patient with conjunctival irritation and discharge points to the toxic conjunctivitis as the underlying etiology. Effective management of conjunctivitis includes timely diagnosis, appropriate differentiation of the various etiologies, and appropriate treatment.

show abstract

Section: Methicillin-resistant S Aureus Conjunctivitismentioning

confidence: 99%

Conjunctivitis: A Systematic Review

Azari

Arabi

2020

JOVR

View full text Add to dashboard Cite

show abstract

“…In general, empiric infectious keratitis, which includes CoNS, is treated topically with fortified cefazolin (50 mg/mL) or vancomycin (20–50 mg/mL), and tobramycin (14 mg/mL) [ 18 ]. Fortified vancomycin (100%) and cefazolin (98%) both appear to be effective against CoNS, but both need to be formulated at a pharmacy.…”

Section: Discussionmentioning

confidence: 99%

Speciation and Antibiotic Susceptibilities of Coagulase Negative Staphylococci Isolated from Ocular Infections

et al. 2021

Self Cite

View full text Add to dashboard Cite

Coagulase-negative staphylococci (CoNS) are frequently occurring ocular opportunistic pathogens that are not easily identifiable to the species level. The goal of this study was to speciate CoNS and document antibiotic susceptibilities from cases of endophthalmitis (n = 50), keratitis (n = 50), and conjunctivitis/blepharitis (n = 50) for empiric therapy. All 150 isolates of CoNS were speciated using (1) API Staph (biochemical system), (2) Biolog GEN III Microplates (phenotypic substrate system), and (3) DNA sequencing of the sodA gene. Disk diffusion antibiotic susceptibilities for topical and intravitreal treatment were determined based on serum standards. CoNS identification to the species level by all three methods indicated that S. epidermidis was the predominant species of CoNS isolated from cases of endophthalmitis (84–90%), keratitis (80–86%), and conjunctivitis/blepharitis (62–68%). Identifications indicated different distributions of CoNS species among endophthalmitis (6), keratitis (10), and conjunctivitis/blepharitis (13). Antibiotic susceptibility profiles support empiric treatment of endophthalmitis with vancomycin, and keratitis treatment with cefazolin or vancomycin. There was no clear antibiotic choice for conjunctivitis/blepharitis. S. epidermidis was the most frequently found CoNS ocular pathogen, and infection by other CoNS appears to be less specific and random. Antibiotic resistance does not appear to be a serious problem associated with CoNS.

show abstract

“…[ 12 ] The risk of keratitis and conjunctivitis due to MRSA has increased. [ 13 ] In MRSA-induced ocular infections, the vision can be compromised despite treatment. Hence, efforts at prevention are recommended.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and determinants of methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus carrier among staff of a tertiary eye hospital in Saudi Arabia

et al. 2021

View full text Add to dashboard Cite

OBJECTIVES: The objective of this study was to estimate the prevalence and risk factors of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) carriers among staff of a tertiary eye hospital in Saudi Arabia. METHODS: This retrospective study was conducted in 2019. Nasal and axillary swabs of health-care staff were used to determine carriers of MRSA. Bacteria were identified by culture and sensitivity tests. These isolates were grouped as antibiotic resistant, sensitive, and others not in the S. aureus group. Demographics and other determinants were associated with carrier status. RESULTS: We evaluated the carrier status of 430 staff. There were 110 (24.9%; 95% confidence interval [CI]: 21.5, 29.7) S. aureus -positive staff, 21 (11.7%; 95% CI: 11.7, 26.4) of who carried the MRSA strain. Carrier status was significantly higher among physicians (31%) compared to nurses (22.5%) and other staff (5.7%) ( P < 0.001). MRSA carrier status was significantly associated with >5 years of employment at the eye hospital ( P = 0.02). MRSA was significantly associated with staff who were of Indian nationality (75%) compared to other nationalities ( P = 0.04) and those who were at the hospital for <5-year stay compared more than 5 years at the hospital ( P = 0.001). All carriers responded to decolonization treatment. CONCLUSIONS: The high prevalence of MRSA and relatively easy treat MRSA carriers points at the need for universal screening for MRSA carriers among eye health staff.

show abstract

MRSA Keratitis and Conjunctivitis: What Does It Mean Practically?

Cited by 7 publications

References 61 publications

Conjunctivitis: A Systematic Review

Conjunctivitis: A Systematic Review

Speciation and Antibiotic Susceptibilities of Coagulase Negative Staphylococci Isolated from Ocular Infections

Prevalence and determinants of methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus carrier among staff of a tertiary eye hospital in Saudi Arabia

Contact Info

Product

Resources

About