MRI morphology of the hippocampus in drug-resistant temporal lobe epilepsy: Shape inflation of left hippocampus and correlation of right-sided hippocampal volume and shape with visuospatial function in patients with right-sided TLE

Yoo, Jae-Gon; Jakabek, David; Ljung, Hanna; Velakoulis, Dennis; Westen, Danielle van; Looi, Jeffrey Cl; Källén, Kristina

doi:10.1016/j.jocn.2019.06.019

Cited by 11 publications

(11 citation statements)

References 29 publications

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“…We hypothesize that functional compensation after disruption of the left hippocampus could lead to increased activation in the right hippocampus, eventually promoting hippocampal growth. A recent shape analysis study interestingly indicated contralateral inflation of the left hippocampus in RTLE, proposing a similar mechanism of functional compensation 47 …”

Section: Discussionmentioning

confidence: 86%

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Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy

Postma

Cury

Baxendale

et al. 2020

Annals of Neurology

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Objective Cognitive problems, especially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilepsy (TLE), but little is known about the relationship of hippocampal morphology with memory. We aimed to relate hippocampal surface‐shape patterns to verbal and visual learning. Methods We analyzed hippocampal surface shapes on high‐resolution magnetic resonance images and the Adult Memory and Information Processing Battery in 145 unilateral refractory TLE patients undergoing epilepsy surgery, a validation set of 55 unilateral refractory TLE patients, and 39 age‐ and sex‐matched healthy volunteers. Results Both left TLE (LTLE) and right TLE (RTLE) patients had lower verbal (LTLE 44 ± 11; RTLE 45 ± 10) and visual learning (LTLE 34 ± 8, RTLE 30 ± 8) scores than healthy controls (verbal 58 ± 8, visual 39 ± 6; p < 0.001). Verbal learning was more impaired the greater the atrophy of the left superolateral hippocampal head. In contrast, visual memory was worse with greater bilateral inferomedial hippocampal atrophy. Postsurgical verbal memory decline was more common in LTLE than in RTLE (reliable change index in LTLE 27% vs RTLE 7%, p = 0.006), whereas there were no differences in postsurgical visual memory decline between those groups. Preoperative atrophy of the left hippocampal tail predicted postsurgical verbal memory decline. Interpretation Memory deficits in TLE are associated with specific morphological alterations of the hippocampus, which could help stratify TLE patients into those at high versus low risk of presurgical or postsurgical memory deficits. This knowledge could improve planning and prognosis of selective epilepsy surgery and neuropsychological counseling in TLE. ANN NEUROL 2020 ANN NEUROL 2020;88:170–182

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Section: Discussionmentioning

confidence: 86%

“…A recent shape analysis study interestingly indicated contralateral inflation of the left hippocampus in RTLE, proposing a similar mechanism of functional compensation. 47 …”

Section: Discussionmentioning

confidence: 99%

Hippocampal Shape Is Associated with Memory Deficits in Temporal Lobe Epilepsy

Postma

Cury

Baxendale

et al. 2020

Annals of Neurology

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“…The different results between the left and right TLE in the corrected analysis may suggest a variance in the intrinsic epileptic networks in patients with unilateral TLE. Another recent study has also confirmed a contralateral shape inflation of the left hippocampus in the right TLE [25]. The connectivity between bilateral temporal lobes has been clearly shown [26,27].…”

Section: Discussionmentioning

confidence: 63%

Structural brain assessment of temporal lobe epilepsy based on voxel-based and surface-based morphological features

Kang

Gao

et al. 2021

Neurol Neurochir Pol.

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Aim of the study. This study aimed to assess the cerebral voxel-based and surface-based morphological abnormalities of patients with temporal lobe epilepsy (TLE). Materials and methods.A total of 100 healthy adults and 73 patients with TLE were enrolled in this study, and their 3D T1-weighted MRI data were collected. Voxel-based morphology (VBM) and surface-based morphology (SBM) tools were used to compare the morphological differences between healthy adults and patients with TLE. Receiver-operating characteristic (ROC) curves were used to acquire the boundary values for detecting morphological abnormalities in regions of interest from the corrected VBM and SBM analysis.Results. Our results showed that cortical voxels and decreased thickness areas were located in the widespread cortex and subcortical structures in the TLE group. However, after completing the analysis, we found that the left-TLE lesions were limited to the left temporal pole and left hippocampus, while the right-TLE lesions were located in the bilateral medial temporal lobe, including the right hippocampus and bilateral amygdala. ROC-curve results showed that the volume of the left hippocampus at 4,124.45 mm3 and the thickness of the left temporal pole cortex at 3.50 mm could be used as optimal boundary values based on the curves of the left-TLE group. The right-TLE group curves were poor. Conclusions.Widespread cerebral morphological TLE abnormalities were represented in this study. However, the lesions may be limited after completing a corrected comparison with clinical information. Boundary values of left-TLE group lesions were also obtained.

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“…Speculatively, this phenomenon may be caused by compensatory mechanisms enhancing functions in the left MTL during the course of right MTL epilepsy. In line with this rationale, for instance, increased subsequent memory‐related fMRI activations in the left hippocampus and amygdala (Powell et al., 2007) and an inflation of left hippocampal shape (Yoo et al., 2019) have been reported in right MTL epilepsy patients compared to healthy controls. These findings tentatively suggest that memory‐related functions in the left MTL may surpass normal level during the course of right MTL epilepsy to compensate for the deficient right MTL.…”

Section: Discussionmentioning

confidence: 83%