We sought to quantify the morphology in vivo of hippocampi in patients with drug resistant temporal lobe epilepsy (TLE) via magnetic resonance imaging (MRI), prior to temporal lobe resection, and the correlation of surface-based shape analysis of morphology and clinical cognitive function.Thirty patients with drug-resistant TLE and twenty healthy controls underwent clinical neuropsychological testing, and brain MRI at Lund University Hospital prior to hippocampal resection. A neuroradiologist categorised radiological findings into normal hippocampus, subtle changes or definite hippocampal sclerosis. We manually segmented MRI of the hippocampus of participants using ANALYZE 11.0 software; and analysed hippocampal shape using SPHARM-PDM software.For radiologist visual-ratings of definite left hippocampal sclerosis in those with left-sided TLE, hippocampal volumes were significantly smaller compared to normal controls. In right-sided TLE we found contralateral shape inflation of the left hippocampus, partially confirming previous shape analytic studies of the hippocampus in TLE. We found significant correlation of volume and surface deflation of the right hippocampus in right-sided TLE with reduced performance on the two right-lateralised visuospatial memory tests, the Rey Complex Figure Test (Immediate and Delayed recall) and the Recognition Memory Test for faces. Decreased hippocampal volume was correlated with poorer performance on these tasks.The morphology of the hippocampus can be quantified via neuroimaging shape analysis in TLE. Contralateral shape inflation of the left hippocampus in right-sided TLE is intriguing, and may result from functional compensation and/or abnormal tissue. In right-sided TLE, hippocampal structural integrity, quantified as hippocampal shape, is correlated with lateralised visuospatial function.
Since gear noise in automotive is one of the most unpleasant noises for passengers, various solutions, such as gear design optimization, tooth modification and transfer path reformations in the vehicle have been developed. But, these attempts are mainly focused on the fundamental mesh excitation of the gear set without any consideration of their harmonic noise (1st, 2nd or higher). Harmonic gear whine noise is easily audible in the vehicle because of their high frequency characteristics in spite of low sound pressure level. This annoying pure-tone noise is usually issued in the transmission system composed of the gears produced by grinding process. This paper will present the main sources of this harmonic gear whine noise with the test results of gears with identical design parameters but having different surface structure (roughness parameters, wave patterns). Additionally, manufacturing guidelines of gear surface structure will be proposed at the end of this paper.
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