MRI and proton-NMR relaxation times in diagnosis and therapeutic monitoring of squamous cell carcinoma

Wagner-Manslau, C.; Lukáš, Peter; Herzog, Mariëlle; Kau, R. J.; Beckers, Kristian

doi:10.1007/bf00599063

Cited by 15 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, the determinations of T1 and T2 relaxation times have been found unreliable in predicting tissue composition in later studies (Hollis et al 1973, Inch et al 1974, Dooms et al 1985, Bottomley et al 1987, Komiyama et al 1987, Just and Thelen 1988, Lundbom et al 1990, Wagner-Manslau et al 1994. Most tumors and other pathological states such as inflammation are characterized by tissue edema and elevated T1 and T2 values, but the different pathological states do not differ significantly from each other (Bottomley 1987).…”

Section: T1 and T2 Relaxation Times And Tissue Specificitymentioning

confidence: 99%

“…Most tumors and other pathological states such as inflammation are characterized by tissue edema and elevated T1 and T2 values, but the different pathological states do not differ significantly from each other (Bottomley 1987). The elevation of relaxation times in neoplastic tissues is usually less than that of resulting from inflammation, but there is a considerable overlap (Dooms et al 1985, Wagner-Manslau et al 1994.…”

Section: T1 and T2 Relaxation Times And Tissue Specificitymentioning

confidence: 99%

“…The combined use of Doppler-blood flow pattern and size criteria has been demonstrated to increase the diagnostic accuracy (Yonetsu et al 2001). Measurements of T1 and T2 relaxation times of metastatic and normal lymph nodes have shown substantial overlap and failed to differentiate normal or in-flammatory nodes from metastatic nodes (Dooms et al 1985, Wagner-Manslau et al 1994. Wagner-Manslau et al (1994) found T1 relaxation time measurements useful in monitoring the tumor and metastatic lymph node response to radiochemothrapy.…”

Section: Lymph Node Imaging Studiesmentioning

confidence: 99%

“…Measurements of T1 and T2 relaxation times of metastatic and normal lymph nodes have shown substantial overlap and failed to differentiate normal or in-flammatory nodes from metastatic nodes (Dooms et al 1985, Wagner-Manslau et al 1994. Wagner-Manslau et al (1994) found T1 relaxation time measurements useful in monitoring the tumor and metastatic lymph node response to radiochemothrapy. The hyperplastic lymph nodes showed significantly lower T1 values compared to malignant nodes, but the differentiation between inflammatory and malignant lymph nodes was not reliable.…”

Section: Lymph Node Imaging Studiesmentioning

confidence: 99%

“…Conventional MRI has been widely used for characterization of head and neck tumors and associated lymphadenopathy with unsatisfactory results (Dooms et al 1985, Vogl et al 1990, Sigal et al 1992, Freling et al 1992and Takashima et al 1993, Wagner-Manslau et al 1994. In salivary gland imaging, it has been reported that highly malignant parotid tumors, which are relatively uncommon, are characterized by low signal intensity on both T1-and T2-weighted images Biller 1989, Takashima et al 1997).…”

Section: T2 Evaluation Versus Sl and Mt Effectsmentioning

confidence: 99%

See 4 more Smart Citations

Spin lock and magnetization transfer imaging of head and neck tumors.

Markkola¹,

Aronen²,

Paavonen³

et al. 1996

Radiology

View full text Add to dashboard Cite

Section: T1 and T2 Relaxation Times And Tissue Specificitymentioning

confidence: 99%

Section: T1 and T2 Relaxation Times And Tissue Specificitymentioning

confidence: 99%

Section: Lymph Node Imaging Studiesmentioning

confidence: 99%

Section: Lymph Node Imaging Studiesmentioning

confidence: 99%

Section: T2 Evaluation Versus Sl and Mt Effectsmentioning

confidence: 99%

See 3 more Smart Citations

Spin lock and magnetization transfer imaging of head and neck tumors.

Markkola¹,

Aronen²,

Paavonen³

et al. 1996

Radiology

View full text Add to dashboard Cite

Characterization of meningiomas with synthetic imaging

et al. 2022

View full text Add to dashboard Cite

Introduction: Synthetic magnetic resonance imaging (SyMRI) is a novel quantitative and qualitative technique that permits the reconstruction of multiple image contrasts and quantitative maps from a single scan, thereby providing quantitative information and reducing scan times. The purpose of this study is to characterize intracranial meningiomas using SyMRI. Methods:The study included 35 patients with meningiomas (6 males, 29 females; mean age 61 ± 17 years; range 21-90 years). Using 3T MR scanners, SyMRI was performed in addition to conventional FSET2, FLAIR, DWI, T1, and T1 with gadolinium. SyMRI software was used to generate T1, T2, and PD quantitative maps. Osirix MD was used to measure quantitative values of T1, T2, and PD using a ROI. Results:We analyzed 42 meningiomas, 8 of which were associated with edema, and 5 contained calcifications.Mean relaxivity values of meningiomas on synthetic T1, T2, and PD maps at 3T MRI were 1382.6 ± 391.7 ms, 95.6 ± 36.5 ms, and 89.1 ± 9.7 pu, respectively. Signal intensities in terms of T1, T2, and PD did not differ significantly between meningiomas with and without edema (p = .994, p = .356, and p = .221, respectively), nor between meningiomas containing and not containing calcifications (p = .840, p = .710, and p = .455, respectively). Values of T1 and T2 measured in meningiomas and the normalappearing white matter approximated reference values found in the literature with other quantitative methods. Conclusion:The presented method offers a novel approach to characterize meningiomas through their relaxation parameters measured with a SyMRI sequence.

show abstract

Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy

et al. 2020

View full text Add to dashboard Cite

Objective: To develop an anthropomorphic, deformable and multimodal pelvis phantom with positron emission tomography extension for radiotherapy (ADAM PETer). Methods: The design of ADAM PETer was based on our previous pelvis phantom (ADAM) and extended for compatibility with PET and use in 3T magnetic resonance imaging (MRI). The formerly manually manufactured silicon organ surrogates were replaced by 3D printed organ shells. Two intraprostatic lesions, four iliac lymph node metastases and two pelvic bone metastases were added to simulate prostate cancer as multifocal and metastatic disease. Radiological properties (computed tomography (CT) and 3T MRI) of cortical bone, bone marrow and adipose tissue were simulated by heavy gypsum, a mixture of Vaseline and K 2 HPO 4 and peanut oil, respectively. For soft tissues, agarose gels with varying concentrations of agarose, gadolinium (Gd) and sodium fluoride (NaF) were developed. The agarose gels were doped with patientspecific activity concentrations of a Fluorine-18 labelled compound and then filled into the 3D printed organ shells of prostate lesions, lymph node and bone metastases. The phantom was imaged at a dual energy CT and a 3T PET/MRI scanner. Results: The compositions of the soft tissue surrogates are the following (given as mass fractions of agarose[w%]/NaF[w%]/Gd[w%]): Muscle (4/1/0.027), prostate (1.35/4.2/0.011), prostate lesions (2.25/4.2/0.0085), lymph node and bone metastases (1.4/4.2/0.025). In all imaging modalities, the phantom simulates human contrast. Intraprostatic lesions appear hypointense as compared to the surrounding normal prostate tissue in T2-weighted MRI. The PET signal of all tumors can be localized as focal spots at their respective site. Activity concentrations of 12.0 kBq/mL (prostate lesion), 12.4 kBq/mL (lymph nodes) and 39.5 kBq/mL (bone metastases) were measured. Conclusion: The ADAM PETer pelvis phantom can be used as multimodal, anthropomorphic model for CT, 3T-MRI and PET measurements. It will be central to simulate and optimize the technical workflow for the integration of PET/MRI-based radiation treatment planning of prostate cancer patients.

show abstract

MRI and proton-NMR relaxation times in diagnosis and therapeutic monitoring of squamous cell carcinoma

Cited by 15 publications

References 21 publications

Spin lock and magnetization transfer imaging of head and neck tumors.

Spin lock and magnetization transfer imaging of head and neck tumors.

Characterization of meningiomas with synthetic imaging

Technical Note: ADAM PETer – An anthropomorphic, deformable and multimodality pelvis phantom with positron emission tomography extension for radiotherapy

Contact Info

Product

Resources

About