Spin lock and magnetization transfer imaging of head and neck tumors.

Markkola, Annamari; Aronen, Hannu J.; Paavonen, Timo; Hopsu, Erkki; Sipilä, Leena M.; Tanttu, Jukka I.; Sepponen, Raimo

doi:10.1148/radiology.200.2.8685328

Cited by 63 publications

(32 citation statements)

References 88 publications

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“…Diffusion imaging enables characterization of tissue at a microscopic level, emphasizing a mechanism that is different from T1 and T2 relaxation 13,14 and potentially improving the performance of MR imaging. 13,15,16 Differences in ADC values between benign and malignant processes of the head and neck have been demonstrated in several studies. ancy.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Nodal Metastasis in Head and Neck Cancer Using a 3T MRI ADC Map

Lee

Tsai

Chuang

et al. 2012

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Prediction of Nodal Metastasis in Head and Neck Cancer Using a 3T MRI ADC Map

Lee

Tsai

Chuang

et al. 2012

AJNR Am J Neuroradiol

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“…The imaging of biologic tissue based on T 1r is currently being investigated for various tissues, including articular cartilage, breast, and head and neck [24][25][26]. In T 1r -weighted MRI of tissues, the image is sensitive to molecular processes that occur over a range of frequencies determined by the amplitude of an applied SL pulse [23].…”

Section: Principle Of Spin-lockingmentioning

confidence: 99%

Basics of Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging

Murase¹

2018

High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications

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Chemical exchange saturation transfer (CEST) is one of the contrast mechanisms in magnetic resonance imaging (MRI) and has been used to detect dilute proteins through the interaction between bulk water and labile solute protons. Amide proton transfer (APT) MRI has been developed for imaging diseases such as acute stroke. Moreover, various CEST agents have been explored to enhance the CEST effect. The contrast mechanism of CEST or APT MRI, however, is complex and depends not only on the concentration of amide protons or CEST agents and exchange properties, but also varies with imaging parameters such as radiofrequency (RF) power and magnetic field strength. When there are multiple exchangeable pools within a single CEST system, the contrast mechanism of CEST becomes even more complex. Numerical simulations are useful and effective for analyzing the complex contrast mechanism of CEST and for investigating the optimal imaging parameter values. In this chapter, we present the basics of CEST or APT MRI and a simple and fast numerical method for solving the time-dependent Bloch-McConnell equations for analyzing the behavior of magnetization and/or contrast mechanism in CEST or APT MRI. We also present a method for analyzing the behavior of magnetization in spin-locking CEST MRI.

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“…45 Strictly speaking T 1 MRI is a form of relaxation governed MR contrasts, however, it is often associated with MT MRI. 46 Using T 1 and MT MRI in combination it was observed that malignant and benign head and neck tumors can be separated with these MR contrasts with specificity exceeding 90%. 46 Similarly, T 1 MRI has been shown to possess unprecedented sensitivity to highlight early treatment response in preclinical tumor models.…”

Section: Magnetization Transfer and Amide Proton Transfer Rate Mrimentioning

confidence: 99%

“…46 Using T 1 and MT MRI in combination it was observed that malignant and benign head and neck tumors can be separated with these MR contrasts with specificity exceeding 90%. 46 Similarly, T 1 MRI has been shown to possess unprecedented sensitivity to highlight early treatment response in preclinical tumor models. 47 Noninvasive information from tumors in situ afforded by MT-based and T 1 MR techniques is substantially adding to the overall picture depicted above for conventional and diffusion MRI.…”

Section: Magnetization Transfer and Amide Proton Transfer Rate Mrimentioning

confidence: 99%