MR Appearance of Subacute Combined Degeneration of the Spinal Cord

Tajima, Yasutaka; Mito, Yasunori; Owada, Yoshiko; Moriwaka, Fumio; Tashiro, Kunio

doi:10.1111/j.1440-1819.1994.tb03022.x

Cited by 9 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[3][4][5] MR imaging may be a useful addition to the clinical assessment in monitoring the efficacy of treatment. 6 Myelopathy is the common manifestation of subacute combined degeneration, however, syringomyelia-like manifestation is not reported in the literature till date, to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 56%

See 1 more Smart Citation

Syringomyelia-like manifestation of subacute combined degeneration

Puri

Chaudhry

Gulati³

2004

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 56%

“…MR imaging negated the existence of syringomyelia but had features described for SACD. [3][4][5][6] and subsequently the serum vitamin B 12 was found to be low. The patient recovered on vitamin B 12 therapy.…”

Section: Discussionmentioning

confidence: 96%

Syringomyelia-like manifestation of subacute combined degeneration

Puri

Chaudhry

Gulati³

2004

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…İntramedüller lezyonu olan olguların ayırıcı tanısında; demiyelinizan hastalıklar, infeksiyöz nedenler, inflamatuvar hastalıklar, neoplazmlar, Vitamin E eksikliği gibi metabolik hastalıklar, karsinömatöz radikülopati, arteriyel veya venöz iskemiler, radyasyon miyeliti yer almaktadır (17,27,28). Demiyelizan hastalıklarda lezyon genellikle iki vertebra aralığını geçmez ve postero-lateral yerleşimli olurken, SKD'deki lezyonlar sıklıkla arka kolumnada görüldüğü ve birkaç vertebra bölümünde uzanabildiği bilinmektedir (29)(30)(31)(32).…”

Section: Discussionunclassified

Vitamin B12 Eksikligine Bagli Subakut Kombine Dejenerasyon: Bir Olgu Nedeniyle Gozden Gecirme

2016

GMJ

View full text Add to dashboard Cite

ÖZETVitamin B12 eksikliği; nöropati, myelopati, demans, nöropsikiyatrik bulgular ve optik nöropati ile presente olabilir. Subakut kombine dejenerasyon (SKD) olarak bilinen B12 vitamini eksikliğine bağlı spinal kord tutulumu, nörolojik bozuklukların %10'unu oluşturur. B12 eksikliğinin nöroloji pratiğinde sık görülmesi ve önemi nedeniyle, b12 vitamini eksikliğine bağlı reversibl spinal kord tutulumu olan bir olguyu, klinik ve görüntüleme bulguları ile birlikte ayrıntılı olarak gözden geçirerek sunduk. ABSTRACTVitamin B12 deficiency may present with neuropathy, myelopathy, dementia, neuropsychiatric disorders and optic neuropathy. Spinal cord involvement due to vitamin B12 deficiency that is known as subacute combined degeneration (SCD), creates 10% of the neurological disorders. Because of the relative frequency and importance of Vitamin B12 deficiency in neurological practice, we presented a detailed review of a case with reversible spinal cord involvement due to vitamin B12 deficiency, with the clinical and imaging features..

show abstract

“…The specific spinal cord lesion caused by vitamin B 12 deficiency, a rare cause of myelopathy, is known as subacute combined degeneration (SCD) [6], is the most frequent neurological manifestation of this deficiency [5,7].…”

mentioning

confidence: 99%

“…It is important to distinguish from other causes of myelopathy that involve the dorsal columns of spinal cord, such as degenerative, demyelinating, infectious, inflammatory, neoplastic, nutritional and vascular disorders [1,4,7,11].…”

mentioning

confidence: 99%

MRI findings in subacute combined degeneration of the spinal cord in a patient with restricted diet

2011

View full text Add to dashboard Cite

Subacute combined degeneration (SCD) is a rare cause of demyelination of the dorsal and lateral columns of the spinal cord, and is a neurogenic complication due to vitamin B 12 deficiency, that we observe with unusual frequency. Improvement in myelopathy with normalization of the abnormalities in the MRI may occur if the replacement of the vitamin B 12 is started early in the course of the disease. A rare case of SCD of the spinal cord due to vitamin B 12 deficiency with a history of diet restrictions is presented.Keywords Subacute combined degeneration (SCD) Á Magnetic resonance imaging (MRI) Á Spinal cord Á Vitamin B 12 Dear Sirs, Vitamin B 12 deficiency can induce pathology in the brain, spinal cord, optic nerve and peripheral nerves [1][2][3][4][5]. The specific spinal cord lesion caused by vitamin B 12 deficiency, a rare cause of myelopathy, is known as subacute combined degeneration (SCD) [6], is the most frequent neurological manifestation of this deficiency [5,7].We describe a rare case with history of vegetarianism with typical symptoms and signs of vitamin B 12 deficiency, with involvement of the posterior and lateral columns, on the cervical cord.A 63-year-old woman was admitted with progressive difficulty in walking for 6 years, paresthesia and weakness in lower extremities. The patient did not include meat and eggs in her diet. Without history of diabetes mellitus, alcohol addiction or gastrointestinal symptoms, she had asymmetric paraparesis, worse on the right (muscular strength 3/6 grade), hyperreflexia and increased muscle tone, particularly on the right, presenting as spasticity and ataxic gait. Loss of vibration and position sense in the lower extremities was observed. Romberg's and Babinski's sign (on the right side) were present. Laboratory tests were remarkable only for vitamin B 12 (\60 pg/ml, reference 198-883); folic acid level was normal (11.9 ng/ml, reference 2.2-17.5). The serologic tests for intrinsic factor, HIV and Lyme were negative, and the CSF analysis was normal.The cervical spine MRI showed hyperintensity on T2-weighted images (Figs. 1, 2, 3) within the posterior aspect of the cervical spinal cord extending from the bulbomedullary region through C4, with better evidence on the right, without expansion of the cord. Axial T2-weighted images showed hyperintensity that corresponded to the posterior and lateral columns. There was no contrast enhancement after administration of gadolinium. Brain MRI was normal.Following clinical and laboratory examinations, the patient was evaluated as cervical myelopathy due to vitamin B 12 deficiency, and the treatment included cyanocobalamin (1,000 lg intramuscular/day for a week and then weekly for 6 weeks), folic acid 5 mg/day and polivitaminic B. After 3 months, she was able to walk alone. Laboratory tests revealed normal values of acid folic and B 12 vitamin. Follow-up cervical MRI (Fig. 4) 6 months later showed marked resolution of the areas of the abnormal signal intensity.Vitamin B 12 cobalamin can be found in food from animal and same plan...

show abstract

MR Appearance of Subacute Combined Degeneration of the Spinal Cord

Cited by 9 publications

References 6 publications

Syringomyelia-like manifestation of subacute combined degeneration

Syringomyelia-like manifestation of subacute combined degeneration

Vitamin B12 Eksikligine Bagli Subakut Kombine Dejenerasyon: Bir Olgu Nedeniyle Gozden Gecirme

MRI findings in subacute combined degeneration of the spinal cord in a patient with restricted diet

Contact Info

Product

Resources

About