Mpox virus and transmission through sexual contact: Defining the research agenda

Low, Nicola; Bachmann, Laura H.; Ogoina, Dimie; McDonald, Robert; Ipekci, Aziz Mert; Quilter, Laura; Çevik, Müge

doi:10.1371/journal.pmed.1004163

Cited by 22 publications

(33 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 64%

“…Islam et al 31 pointed to a possible association between epidemiology of mpox infection and sexual orientation patients. Low et al 32 found similar findings about the disproportionately high burden of mpox among sexual minorities in a multicountry outbreak. The study documented that mpox transmission occurs through sexual contact among sexual minorities (both penetrative and nonpenetrative), more than casual skin‐to‐skin contact 32 …”

Section: Discussionmentioning

confidence: 66%

“…The study documented that mpox transmission occurs through sexual contact among sexual minorities (both penetrative and nonpenetrative), more than casual skin-to-skin contact. 32 The study reviewed here reported epidemiology and mpox outbreak management strategies and infection prevention and control efforts in some school settings in England subsequent to four different cases of exposure. Following the 28-day follow-up window which involved isolation and separation of no less than 440 exposed persons, zero case of mpox infection was identified as none of the low, medium, and high-risk groups were infected.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

School‐based interventions on Mpox: A scoping review

Amzat

Kanmodi

Aminu

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

Background and Aims The 2022 multicountry mpox outbreak necessitated the declaration of mpox as a public health emergency. This is the first time a wide mpox spread and human‐to‐human transmission are recorded in several countries outside West and Central Africa. The outbreak reveals a strong need for wider intervention to increase awareness and control measures on mpox, especially in schools. This scoping review aims to summarize the existing evidence concerning school‐based interventions on mpox globally. Methods The review methodology was based on the Arksey and O'Malley guidelines and it was reported in strict adherence with the PRISMA‐ScR checklist. Ten databases were searched to retrieve literature relevant to the review topic. Thereafter, the retrieved literature were deduplicated and screened for inclusion into the review based on a set of eligibility criteria. Only one journal paper, a short communication on the national monkeypox outbreak in England, satisfied the selection criteria and was included in the review. Data extracted from the included paper were collated, summarized, and presented. Results The paper described how suspected cases of mpox infection were managed in some school settings through vaccination and self‐isolation approaches and revealed a low (11%) mpox vaccination uptake rate in school‐setting. The preventive methods adopted, such as the exclusion of exposed persons from school (in three school settings) and separation of those exposed those who were not in contact with the affected persons (one school setting), played a major role in the low transmission rate reported. This review also found a huge dearth of literature on school‐based interventions on mpox despite its global spread. Conclusion With the call for a multisectoral approach in the fight against mpox, it pays to leverage on the potential of school settings in public health actions against mpox.

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

School‐based interventions on Mpox: A scoping review

Amzat

Kanmodi

Aminu

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…Transmission of mpox virus has been occurring since 1960s in the nonhuman primates. Evidence of animal‐to‐animal transmission both in the natural environment and laboratory is well documented 4,57–60 . The natural history of mpox virus is yet to be understood well.…”

Section: Resultsmentioning

confidence: 99%

Molecular epidemiology, transmission and clinical features of 2022‐mpox outbreak: A systematic review

Sharif,

Alzahrani

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

Background and AimsThe 2022‐mpox outbreak has spread worldwide in a short time. Integrated knowledge of the epidemiology, clinical characteristics, and transmission of mpox are limited. This systematic review of peer‐reviewed articles and gray literature was conducted to shed light on the epidemiology, clinical features, and transmission of 2022‐mpox outbreak.MethodsWe identified 45 peer‐reviewed manuscripts for data analysis. The standards of the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Statement and Cochrane Collaboration were followed for conducting the study.ResultsThe case number of mpox has increased about 100 times worldwide. About 99% of the cases in 2022 outbreak was from non‐endemic regions. Men (70%–98% cases) were mostly infected with homosexual and bisexual behavior (30%–60%). The ages of the infected people ranged between 30 and 40 years. The presence of HIV and sexually transmitted infections among 30%–60% of cases were reported. Human‐to‐human transmission via direct contact and different body fluids were involved in the majority of the cases (90%–100%). Lesions in genitals, perianal, and anogenital areas were more prevalent. Unusually, pharyngitis (15%–40%) and proctitis (20%–40%) were more common during 2022 outbreak than pre‐2022 outbreaks. Brincidofovir is approved for the treatment of smallpox by FDA (USA). Two vaccines, including JYNNEOSTM and ACAM2000®, are approved and used for pre‐ and post‐prophylaxis in cases. About 100% of the cases in non‐endemic regions were associated with isolates of IIb clade with a divergence of 0.0018–0.0035. Isolates from B.1 lineage were the most predominant followed by B.1.2 and B.1.10.ConclusionThis study will add integrated knowledge of the epidemiology, clinical features, and transmission of mpox.

show abstract

“…MPVX is a zoonosis that can be acquired through contact with bodily fluids, lesions on the skin or on internal mucosal surfaces, such as in the mouth or throat, respiratory droplets from infected animals or humans, or contaminated objects [ 6 , 7 ]. Although human-to-human transmission is traditionally limited, recent evidence indicates that MPXV has found a novel route to transmit between humans [ 8 , 9 , 10 , 11 ]. In May 2022, there was the identification of clusters of MPVX cases in several non-endemic countries, leading to the “WHO Declaration of Monkeypox” as a global public health emergency [ 1 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a ddPCR Commercial Assay for the Absolute Quantification of the Monkeypox Virus West Africa in Clinical Samples

et al. 2023

View full text Add to dashboard Cite

Background: Monkeypox virus (MPXV) is a double-stranded DNA virus belonging to the orthopoxvirus genus in the family Poxviridae. Distinct clades are identified: the clade I belonging to the Central African (or Congo Basin) clade and the subclades IIa and IIb belonging to the West African clade. Here, a commercial droplet digital PCR (ddPCR) assay was evaluated for the quantification of the MPXV West Africa clade in clinical samples. Methods: The ddPCR reaction was assessed as a duplex assay using RPP30 as an internal amplification control. A total of 60 clinical specimens were tested, 40 positives (skin lesions, n=10; rectal swabs, n = 10; pharyngeal swabs, n = 10; and whole blood, n = 10), and 20 negatives (n = 5 for each biological matrix) were found at the routine molecular diagnostics (orthopoxvirus qPCR followed by confirmation with Sanger sequencing). To evaluate the analytical sensitivity, the ddPCR reaction was first analyzed on serial dilutions of synthetic DNA spiked in water and in negative biological matrices, achieving a limit of detection of 3.5 copy/µL. Results: Regarding the clinical samples, compared to routine molecular diagnostics, the ddPCR duplex assay showed 100% of specificity for all biological matrices and 100% sensitivity (10/10) for lesions, 100% (10/10) for rectal swabs, 90% (9/10) for pharyngeal swabs, and 60% (6/10) for whole blood. Conclusion: Overall, our data showed that the commercial ddPCR assay allowed the DNA detection of MPXV in 87.5% (35/40) of our cohort, highlighting useful technical indications for the different specimens with a potential greatest performance for skin lesions and rectal swabs.

show abstract

Mpox virus and transmission through sexual contact: Defining the research agenda

Cited by 22 publications

References 28 publications

School‐based interventions on Mpox: A scoping review

School‐based interventions on Mpox: A scoping review

Molecular epidemiology, transmission and clinical features of 2022‐mpox outbreak: A systematic review

Evaluation of a ddPCR Commercial Assay for the Absolute Quantification of the Monkeypox Virus West Africa in Clinical Samples

Contact Info

Product

Resources

About