Mouth self-examination as a screening tool for oral cancer in a high-risk group of patients with Fanconi anemia

Furquim, Camila Pinheiro; Pivovar, Allana; Cavalcanti, Laura Grein; Araújo, Renata Fuentes; Bonfim, Carmem; Torres‐Pereira, Cassius Carvalho

doi:10.1016/j.oooo.2014.06.012

Cited by 16 publications

(20 citation statements)

References 24 publications

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“…Specificity rate was very high at 95 percent, which concurs with one study on a high risk population in India . However, other studies reported much lower specificity rates of 44–56 percent . Variation of rates could be attributed to a few factors.…”

Section: Discussionsupporting

confidence: 87%

“…Findings of the present study indicated that respondents were able to correctly identify absence of oral lesions, however they were unable to identify presence of lesions. Overall sensitivity was only 8.6 percent, much lower than reported rates of 18–50 percent in other studies . Specificity rate was very high at 95 percent, which concurs with one study on a high risk population in India .…”

Section: Discussionsupporting

confidence: 86%

“…A large‐scale study on a high risk population in India highlighted that educating the public about MSE promotes early detection, where detection rates were found to be comparable with those previously reported when health workers were employed . However, evidence regarding the efficacy of MSE as a diagnostic or screening tool is scarce with only four published studies to date reporting varying rates of sensitivity and specificity. The diagnostic accuracy of MSE needs to be established first prior to advocating it as a potential nationwide screening tool for early detection.…”

Section: Introductionmentioning

confidence: 91%

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Mouth self‐examination as a screening tool for oral potentially malignant disorders among a high‐risk Indigenous population

Ghani

Razak

Doss

et al. 2019

J Public Health Dent

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Objectives To evaluate the efficacy of mouth self‐examination (MSE) as a self‐screening tool for detection of oral mucosal lesions among an Indigenous population in Malaysia at high risk for oral premalignant and malignant disorders. Methods Two villages were selected as the sampling frame based on prevalence of tobacco and betel quid chewing habit. Respondents were asked to check their mouth for presence of lesion or abnormalities. Education on oral cancer, including MSE, was provided. Subsequently, respondents were asked to perform MSE. Finally, a clinical oral examination (COE) was done by a specialist and the presence of oral mucosal lesions was recorded. Results Almost 64.5 percent of respondents exhibited high levels of difficulty and low mucosal visualization and retracting ability, whereas 3.0 percent demonstrated high attention level when performing MSE. Prevalence of oral mucosal lesions was 59.0 percent, whereas the prevalence of oral potentially malignant disorders (OPMDs) was 9.0 percent. Detection of oral lesions by respondents using MSE was lower than detection by the gold standard. Sensitivity and specificity of MSE for detection of all types of lesions were 8.6 and 95.0 percent respectively. When analyzing each lesion type separately, MSE was found to be most sensitive in detection of swellings (10.0 percent), and most specific in identifying white lesions (97.8 percent). For detection of OPMDs, although specificity was high (98.9 percent), sensitivity (0 percent), and +LR (0) was poor. Conclusion MSE is not an effective self‐screening tool for early detection of potentially malignant lesions for this population.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Mouth self‐examination as a screening tool for oral potentially malignant disorders among a high‐risk Indigenous population

Ghani

Razak

Doss

et al. 2019

J Public Health Dent

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“…Although some authors have suggested self-examination of the mouth for oral cancer screening in high-risk FA patients [13], regular examination by an oral medicine specialist must be encouraged in these patients.…”

Section: Resultsmentioning

confidence: 99%

Localized gingival erythroleukoplakia in a 57-year-old Fanconi anemia patient: a case report

Moreau

Renoux

Mignerey³

et al. 2017

Med Buccale Chir Buccale

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--Fanconi anemia is an extremely rare genetic disorder that has several modes of presentations, and it can lead to multiple hematological malignancies and malignant solid tumors, especially squamous cell carcinoma. Erythroleukoplakia is a rare oral mucosal disorder, associated with a high risk of malignant transformation. We report a rare case of localized gingival erythroleukoplakia in a 57-year-old female patient with Fanconi anemia that eventually revealed to be gingival in situ squamous cell carcinoma. Early surgical excision was performed but two local recurrences occurred. Early treatment of the recurrences allowed for adequate management of the oral malignancy. The present case aims to underline the need for thorough clinical examination and regular follow-up sessions in the early detection of premalignant and malignant conditions, especially in patients with diseases predisposing to oral cancer.

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“…Exfoliative cytology is an inexpensive and non-invasive technique that can be used as a tool for oral cancer prevention in patients with FA. [28][29][30] These examinations are important tools of oral screenings and they may decrease the need for surgical approaches and can improve survival. Further investigation should be performed to elucidate the mechanisms involved in oral mucosal changes in children and adolescents with FA, who were submitted to hematopoietic stem cell transplantation, especially those related to the early development of squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Exfoliative Cytology in the Oral Mucosa of Patients with Fanconi Anaemia: A Morphometric Approach

Machado¹,

D'Agulham²,

Chaiben³

et al. 2017

J Dent Indones

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Patients with Fanconi anaemia (FA) are prone to develop squamous cell carcinomas at an early age. Exfoliative cytology can be used to detect changes to the health of the oral mucosa. Objective: The aim of this study was to evaluate morphometrical and morphological changes using exfoliative cytology and to analyse and quantify the proliferative activity using silver nucleolar organiser regions (AgNOR) in epithelial cells of the tongue in FA patients, after haematopoietic stem cell transplantation (HSCT). Methods: Oral smears were collected from the tongues of 20 FA children and adolescents after haematopoietic stem cell transplantation (FA) and 20 healthy children (C) using exfoliative cytology. The smears were stained using the Papanicolaou technique and silver impregnation. The cells were morphologically analysed and the nuclear area (NA), the cytoplasmic area (CA), and the nucleusto-cytoplasm area ratio (NA/CA) were calculated. Results: Mean values for the FA and C groups were: NA (71.85 and 55.21µm²; p< 0.01); CA (2127.48 and 1441.61µm²; p< 0.01); NA/CA (0.03 and 0.04; p< 0.01), respectively. A significant increase in the NA and CA for the FA group (p< 0.01) was seen, and an alteration in the NA/CA ratio. No morphological differences were found between the groups. Class I smears were predominant in both groups. No differences were found between the groups for the mean values of AgNORs per nucleus. Conclusion: This study suggests that morphological changes occurred in the oral epithelium cells of children and adolescents with Fanconi anaemia when subjected to HSCT.

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Mouth self-examination as a screening tool for oral cancer in a high-risk group of patients with Fanconi anemia

Cited by 16 publications

References 24 publications

Mouth self‐examination as a screening tool for oral potentially malignant disorders among a high‐risk Indigenous population

Mouth self‐examination as a screening tool for oral potentially malignant disorders among a high‐risk Indigenous population

Localized gingival erythroleukoplakia in a 57-year-old Fanconi anemia patient: a case report

Exfoliative Cytology in the Oral Mucosa of Patients with Fanconi Anaemia: A Morphometric Approach

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