The future of the field of entrepreneurship is bright primarily because of the many research opportunities to make a difference. However, as scholars, how can we find these opportunities and choose the ones most likely to contribute to the literature? This essay introduces me-search as a tool for blazing new trails in entrepreneurship research. Me-search focuses scholarly attention on issues from one’s personal experiences as a useful tool for generating research opportunities in which one has idiosyncratic knowledge and is motivated to see it through to publication. In conducting me-search, we highlight the importance of solving a practical problem, problematizing, contextualizing, and abstracting entrepreneurship research, and using empirical theorizing to explore entrepreneurial phenomena. We hope that this chapter gives scholars the direction to find research opportunities and the confidence to pursue them; research opportunities that have the potential to make an important contribution to the entrepreneurship field.