MoS2 nanoflower-mediated enhanced intratumoral penetration and piezoelectric catalytic therapy

He, Yaqian; Xu, Zichuang; He, Yuchu; Cao, Guanghui; Song, Ning; Tang, Yongfu; Wang, Jidong; Yuan, Yi; Ma, Zhenhe; Wang, Desong; Gao, Dawei

doi:10.1016/j.biomaterials.2022.121816

Cited by 24 publications

(11 citation statements)

References 41 publications

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“…Applications in tissue regeneration, nerve stimulation, drug delivery, wound healing, dynamic therapy, and tooth whitening have been developed in eye-opening ways. 5,9,80,[146][147][148] The electrical signals generated by piezoelectric materials were used for power supply, information transmission, electrical stimulation, control of valve channels, change in charge carrier behavior, and participation in redox reactions. Inspired by these research results, the construction of intelligent closedloop anti-tumor systems based on piezoelectric materials integrating sensing, detection, treatment, diagnosis, and treatment has become a future development trend.…”

Section: Discussionmentioning

confidence: 99%

The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

et al. 2023

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Section: Discussionmentioning

confidence: 99%

The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

et al. 2023

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“…[ 116 ] The potential of the US‐triggered piezocatalysis as water‐splitting materials is promising for the release of oxygen molecules within tumor cells. [ 117 ] Various materials, such as BTO (bismuth‐based materials), ZnO (metal oxide), SrTiO 3 (perovskite‐structured materials), and WS 2 (2D material) have been explored as sonocatalysts in biomedicine. The built‐in electric field of the piezoelectric materials, known as the “piezoelectric effect,” showed great potential as a sonosensitizer for the excellent therapeutic activities.…”

Section: The Tactics For Hypoxic Tme Reversing and The Underlying Mec...mentioning

confidence: 99%

Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Li,

Yue,

Tang

et al. 2023

Adv Healthcare Materials

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Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of malignant tumors owing to its powerful penetration ability, noninvasiveness, site‐confined irradiation and excellent therapeutic efficacy. However, the traditional SDT, which relies on oxygen availability, often fails to generate a satisfactory level of reactive oxygen species (ROS) because of the widespread issue of hypoxia in the tumor microenvironment (TME) of solid tumors. To address this challenge, various approaches have been developed to alleviate hypoxia and improve the efficiency of SDT. These strategies aim to either increase oxygen supply or prevent hypoxia exacerbation, thereby enhancing the effectiveness of SDT. In view of this, the current review provides an overview of these strategies and their underlying principles, focusing on the circulation of oxygen from consumption to external supply. The detailed research examples conducted using these strategies in combination with SDT were also discussed. Additionally, this review highlights the future prospects and challenges of the hypoxia‐alleviated SDT, along with the key considerations for future clinical applications. These considerations include the development of efficient oxygen delivery systems, the accurate methods for hypoxia detection, and the exploration of combination therapies to optimize SDT outcomes.This article is protected by copyright. All rights reserved

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“…To increase the effectiveness of drug administration, a piezo−drug nanocarrier was developed by combining MoS 2 and molecular medicine to lower the interstitial tumor plasma fluid pressure. Upon ultrasound stimulation, •OH radicals are produced in the presence of MoS 2 via a piezocatalytic process, which can interact with doxorubicin to lower tumor cell plasma fluid pressure, thereby increasing drug release and slowing tumor growth [ 58 ].…”

Section: Application Of Piezoelectric Nms In Pedtmentioning

confidence: 99%

Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy

Shi

et al. 2023

Molecules

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Cancer is one of the deadliest diseases, having spurred researchers to explore effective therapeutic strategies for several centuries. Although efficacious, conventional chemotherapy usually introduces various side effects, such as cytotoxicity or multi−drug resistance. In recent decades, nanomaterials, possessing unique physical and chemical properties, have been used for the treatment of a wide range of cancers. Dynamic therapies, which can kill target cells using reactive oxygen species (ROS), are promising for tumor treatment, as they overcome the drawbacks of chemotherapy methods. Piezoelectric nanomaterials, featuring a unique property to convert ultrasound vibration energy into electrical energy, have also attracted increasing attention in biomedical research, as the piezoelectric effect can drive chemical reactions to generate ROS, leading to the newly emerging technique of ultrasound−driven tumor therapy. Piezoelectric materials are expected to bring a better solution for efficient and safe cancer treatment, as well as patient pain relief. In this review article, we highlight the most recent achievements of piezoelectric biomaterials for tumor therapy, including the mechanism of piezoelectric catalysis, conventional piezoelectric materials, modified piezoelectric materials and multifunctional piezoelectric materials for tumor treatment.

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MoS2 nanoflower-mediated enhanced intratumoral penetration and piezoelectric catalytic therapy

Cited by 24 publications

References 41 publications

The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy

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