Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet

Metwally, Fateheya M.; Rashad, Hend; Mahmoud, Amira A.

doi:10.1016/j.physbeh.2018.12.010

Cited by 27 publications

(13 citation statements)

References 62 publications

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“…In addition, GbE raised adiponectin levels of OVX animals, what may have been a consequence of the lower adiposity, since this adipokine secretion is inversely proportional to body fat 11 . Corroborating the present findings, it has been reported that supplementation with Morus alba extract, an anti-inflammatory and anti-oxidant herbal medicine, to female rats fed a high-cholesterol diet, reduced body adiposity, up-regulated adiponectin gene expression, down-regulated leptin and resistin gene expressions, and improved insulin sensitivity in the visceral adipose tissue 42 .…”

Section: Discussionsupporting

confidence: 88%

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Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Banin

Machado

Andrade

et al. 2021

Sci Rep

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While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, and increased the anxiety index (p = 0.048 vs. Sham + GbE) while it decreased the latency to immobility (p = 0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p = 0.004) and increased the latency to immobility (p = 0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p = 0.047) and total cholesterol levels (p = 0.022) were associated with anxious-like behaviours while body adiposity (p = 0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause.

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Section: Discussionsupporting

confidence: 88%

“…In agreement with the present findings, the hypercholesterolemia and hyperleptinemia of obese female rats have been shown to be positively associated with mood and anxiety symptoms. Interestingly, this study also reported a reduction of depressiveand anxious-like behaviours by the oral supplementation with Morus alba extract 42 .…”

Section: Discussionsupporting

confidence: 59%

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Banin

Machado

Andrade

et al. 2021

Sci Rep

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show abstract

“…Morus alba leaves ethanol extract markedly decreased body weight gain, and diminished the elevated cholesterol, triglycerides, atherogenic index and coronary artery indices, it also decreased insulin resistance and glucose level in hyperlidemic rats induced by high-cholesterol diet (HCD). The serum leptin and resist in and their mRNA expression in visceral adipose tissue were significantly decreased by the extract, while, it increased serum adiponectin, and its expression significantly in visceral adipose tissue in hyperlipidemic rats (27) .…”

Section: Hypolipidemic and Anti-obesity Effectsmentioning

confidence: 83%

Anti-obesity and hypolipidemic effects of Morus alba- A review

Kadhum

Thuwaini

2021

GSC Biol. and Pharm. Sci.

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The prevalence of obesity was worldwide increase in the last 60 years. Obesity represented one of the public health problems, it markedly increased the incidence of many diseases: fatty liver, type 2 diabetes, hypertension, ischemic heart diseases, sleep apnea, osteoporosis, dementia, tumors and many other disorders. Recent reviews showed that many medicinal plants possesses anti-obesity effect. In the current review, PubMed, Web Science, Science Direct, Research gate, Academia.edu and Scopus were searched to verify the hypolipidemic and anti-obesity activities of Morus alba.

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“…For example, Abd El Aal et al (2017) have demonstrated that carvacrol significantly decreases total cholesterol, triglycerides, LDL, leptin, and increases HDL and adiponectin. Metwally et al (2019) have reported that reduction of visceral adiposity and serum leptin and resistin levels, increase in serum adiponectin levels, and reduction in serum total cholesterol, triglyceride, insulin and glucose levels are determined in M. alba leaf extract treated hypercholesterolemic rats for 8 weeks. Resveratrol has an increasing activity of adiponectin and decreasing activity of leptin and insulin in hypercholesterolemic rabbits and has a therapeutic potential for lipidlowering effect (Jimoh et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Effects of Tribulus terrestris, Avena sativa and White Ginseng on Adiponectin, Leptin, Resistin, Fatty Acid Binding Protein 4, Homocysteine and Paraoxonase-1 Levels in Hypercholesterolemic Rats

Nalbant¹,

Bilgili²,

Hanedan³

et al. 2020

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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This study was aimed to evaluate the effects of Tribulus terrestris (TT), Avena sativa (AS), white ginseng (WG), and a triple combination (TC) powder on adipokines, homocysteine and paraoxonase-1 levels in hypercholesterolemic rats. Hypercholesterolemia in rats was induced by diet added 2% cholesterol. Herbal treatment groups consisted of Group III (TT), Group IV (AS), Group V (WG) and Group VI (triple combination of TT, AS and WG). Significant increase in total cholesterol, LDL-C, homocysteine, leptin and resistin levels (P<0.05) and insignificant decrease in adiponectin, and paraoxonase-1 levels (P>0.05) were found in hypercholesterolemic rats. The treatment combination with TT, AS and WG significantly reduced total cholesterol, LDL-C, homocysteine, leptin and resistin levels in hypercholesterolemic rats (P<0.05). In conclusion, it was found that TT, AS and WG had positive effects on reversing the effects of hypercholesterolemia in rats. The combination treatment with TT, AS and WG may have therapeutic effects in the treatment of hypercholesterolemia.

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Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet

Cited by 27 publications

References 62 publications

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

Anti-obesity and hypolipidemic effects of Morus alba- A review

Effects of Tribulus terrestris, Avena sativa and White Ginseng on Adiponectin, Leptin, Resistin, Fatty Acid Binding Protein 4, Homocysteine and Paraoxonase-1 Levels in Hypercholesterolemic Rats

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