Effects of Tribulus terrestris, Avena sativa and White Ginseng on Adiponectin, Leptin, Resistin, Fatty Acid Binding Protein 4, Homocysteine and Paraoxonase-1 Levels in Hypercholesterolemic Rats

Nalbant, Ahmet; Bilgili, Ali; Hanedan, Başak; Akdoğan, Mehmet

doi:10.38093/cupmap.829184

Cited by 1 publication

(2 citation statements)

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“…Plant extracts of these species show a wide range of biological actions, including reduction in body weight and appetite suppression, effects on leptin, ghrelin, and adiponectin levels, inhibition of pancreatic lipase activity which prevents digestion and absorption of fats and carbohydrates, reduction in the glucose, total cholesterol, and triglyceride content in the blood, etc. [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. The weight-reducing ability of T. terrestris plant extracts has been reported [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…may also have antiadipogenic effects and improve fat oxidation and energy expenditure [ 35 , 36 , 37 , 38 , 39 , 40 ]. Tribulus terrestris may be effective in treating hypercholesterolemia by reducing cholesterol, homocysteine, leptin, and resistin levels and increasing adipokine expression; it has also been shown to have hypolipidemic and antihyperglycemic activities [ 41 , 42 , 43 , 44 ]. Dioscorea spp.…”

Section: Introductionmentioning

confidence: 99%

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The Hypoglycemic and Hypocholesterolemic Activity of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus Cell Culture Biomass in Rats with High-Fat Diet-Induced Obesity

et al. 2023

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Obesity, and its consequences for human health, is a huge and complicated problem that has no simple solution. The constant search for natural and safe compounds with systemic action that can be used for obesity prophylactics and treatment is hampered by the limited availability and variable quality of biomass of wild medicinal plants. Plant cell biotechnology is an alternative approach for the sustainable production of vegetative biomass or individual phytochemicals with high therapeutic potential. In this study, the suspension cell biomass of the medicinal plants, Dioscorea deltoidea Wall., Tribulus terrestris L., and Panax japonicus (T. Nees) C.A. Mey, produced in 20 L and 630 L bioreactors, were tested for therapeutic effects in rat models with alimentary-induced obesity. Three-month intake of water infusions of dry cell biomass (100 mg/g body weight) against the background of a hypercaloric diet reduced weight gain and the proportion of fat mass in the obese animals. In addition, cell biomass preparation reduced the intracellular dehydration and balanced the amounts of intra- and extracellular fluids in the body as determined by bioimpedance spectroscopy. A significant decrease in the glucose and cholesterol levels in the blood was also observed as a result of cell biomass administration for all species. Hypocholesterolemic activity reduced in the line P. japonicus > D. deltoidea > T. terrestris/liraglutide > intact group > control group. By the sum of parameters tested, the cell culture of D. deltoidea was considered the most effective in mitigating diet-induced obesity, with positive effects sometimes exceeding those of the reference drug liraglutide. A safety assessment of D. deltoidea cell phytopreparation showed no toxic effect on the reproductive function of the animals and their offspring. These results support the potential application of the biotechnologically produced cell biomass of medicinal plant species as safe and effective natural remedies for the treatment of obesity and related complications, particularly for the long-term treatment and during pregnancy and lactation periods when conventional treatment is often contraindicated.

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