Mortality risk factors in premature infants with respiratory distress syndrome treated by mechanical ventilation

Fidanovski, Dusko; Milev, Vladislav; Sajkovski, Aleksandar; Hristovski, Antoni; Sofijanova, Aspazija; Kojic, Ljiljana; Kimovska, Mica

doi:10.2298/sarh0502029f

Cited by 17 publications

(14 citation statements)

References 8 publications

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“…In compatible to our results Arit demonstrated much of the mortality rate in neonates with low gestational age and low birth weight [13]. Fidanovski also detected higher risk of mortality in infants with lower birth weight and shorter gestational age in 126 premature infants hospitalized at Pediatric Intensive Care Unit [15].…”

Section: Discussionsupporting

confidence: 89%

The Incidence of Respiratory Distress Syndrome among Preterm Infants Admitted to Neonatal Intensive Care Unit: A Retrospective Study

Saboute¹,

Kashaki²,

Bordbar³

et al. 2015

OJPed

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Background: Respiratory distress syndrome (RDS) or hyaline membrane disease (HMD) is the most common cause of neonatal morbidity and mortality in preterm infants. We aimed to determine the frequency of RDS among 3 groups of preterm infants and the value of some related factors. Methods: A cross-sectional, descriptive analytical investigation was carried out in the NICU ward of Akbarabadi Hospital (Tehran-Iran) during spring 2011. Newborns' data were collected and assessed by using their hospital medical records. Seventy-three preterm infants with gestational age < 34 weeks were hospitalized in the NICU. All participants were divided into 3 groups: extremely preterm (<28 weeks), very preterm (28 to <32 weeks) and moderate preterm (32 to 34 weeks). Frequency of RDS and some related factors were compared among 3 groups. Results: RDS was observed in 65.6% of all participants; however frequency of RDS was not different between three groups. An inversely correlation was found between gestational age and mortality rate (p = 0.05). In regard to Betamethasone administration prior to birth, this interval was significantly longer in alive neonates in comparison to infants who died (p < 0.05). Conclusion: RDS was frequent in preterm neonates with gestational age < 32 weeks. Time of Betamethasone administration prior to birth can significantly influence on neonatal mortality rate.

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Section: Discussionsupporting

confidence: 89%

The Incidence of Respiratory Distress Syndrome among Preterm Infants Admitted to Neonatal Intensive Care Unit: A Retrospective Study

Saboute¹,

Kashaki²,

Bordbar³

et al. 2015

OJPed

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“…10,11 The study observed 27% newborn have had severe respiratory distress which was less as compared to study conducted by Derek C. 12 Study also revealed max, 57.14% newborn developed severe respiratory distress had low APGAR score. Similar findings have also been reported by Lureti M et al, Fidanovski D et al and Gouyon J et al 13,14,9 Our study observed that max 15,16 Primi para was significantly associated with respiratory distress has been reported by Dani C et al, whereas multipara noted by Mathur N et al 15,17 The caesarean mode of delivery was associated for newborn respiratory distress mentioned by Dani C et al, Geller E et al and Gouyon J et al, respectively. 9,15,18 Low gestational age at the time of delivery was a risk factor for respiratory distress also observed by Dani C et al, and Lureti M et al 13,15 The studies conducted by Lureti M et al and Miller H et al, also mentioned that low birth weight is a risk factor for respiratory distress among newborn baby.…”

Section: Discussionsupporting

confidence: 89%

Clinical profile and outcome of respiratory distress in newborns admitted in rural tertiary health care centre of Maharashtra, India

Kshirsagar

Mohite

2019

Int J Contemp Pediatr

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Background: Respiratory distress is most common symptom complexes seen in newborn infants lead to high mortality. The objectives were to study various etiological factors, maternal and neonatal risk factors for development of respiratory distress along with need for CPAP, mechanical ventilation and surfactant to assess the immediate clinical outcome in newborns.Methods: The study was conducted at Krishna Hospital and Medical Research Centre, Karad in period of January to August 2018. A total of 100 neonates who were admitted in NICU within 72 hours of life were studied by clinical examination and relevant investigations. The severity of distress was assessed by Silverman-Anderson scoring, Downe’s scoring and APGAR scoring respectively for neonates.Results: It was observed that max, 90% of the distress cases were of respiratory in origin and high severity of distress was observed among 27% newborns. The proportion of respiratory distress was higher, 51% in males and low APGAR score was reported in 14% cases. Among respiratory etiology of respiratory distress, high proportion was of TTNB 35.55%. The maternal and new born factors like maternal age >30 years (32%), gestational age 28-30 weeks (87.5%), gravid 2 and 3 mothers (35%), female gender (32.6%), low birth weight (70%) developed severe distress respectively. The recovery rate of respiratory distress due to respiratory etiology was of 88.8%.Conclusions: Transient tachypnoea of new-born is the most common cause among new-borns with respiratory distress. New-borns with low gestational age, low birth weight baby, low APGAR score is more prone to develop severe respiratory distress.

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“…Prematurez extrema, neonato con los siguientes hallazgos en la autopsia: desarrollo pulmonar en fase canalicular (16-24 semanas) y signos morfológicos de hipoxia fetal aguda intrauterina (9). Enfermedad de membrana hialina, neonato con distrés respiratorio, requerimientos de O2 aumentado, radiología compatible y hallazgos de membranas hialinas en bronquiolos terminales, alvéolos y atelectasias (25). Hipoplasia e inmadurez pulmonar en gestaciones menores de 24 semanas, habitualmente con rotura prematura de membranas de inicio precoz y desarrollo pulmonar en fase canalicular en la autopsia (26).…”

Section: Pacientes Y Métodosunclassified

Mortalidad perinatal en el parto prematuro entre 22 y 34 semanas en un hospital público de Santiago, Chile

et al. 2012

Rev. chil. obstet. ginecol.

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RESUMENObjetivo: Conocer la mortalidad perinatal del parto prematuro y los factores de riesgo asociados, usando los datos perinatales clínicos, los resultados de laboratorio y los hallazgos patológicos del feto, neonato y placenta. Métodos: Estudio retrospectivo, cohorte de 407 nacimientos prematuros, únicos, entre 22.0 y 34.0 semanas de gestación. Se estudiaron las muertes fetales y neonatales hasta los 7 días de vida. Fallecieron 122 niños (64 muertes fetales y 58 neonatales), 78 tuvieron autopsia. Resultados: La mortalidad perinatal fue de 30% (122/407). El 71% (87/122) de las muertes ocurrieron antes de las 30 semanas y el 81% (99/122) en nacidos con peso menor de 1500 gramos. Las principales causas de muerte perinatal según el factor asociado con el parto prematuro fueron: infección bacteriana ascendente (IBA) 41% (50/122), anomalía congénita 20% (24/122) e hipertensión arterial 12% (15/122). Los factores de riesgo de muerte perinatal, identificados mediante análisis de regresión logística, fueron: edad gestacional al parto (p<0,001), anomalía congénita (p<0,001), IBA (p=0,02) e hipertensión arterial (p=0,03). Las principales causas de muerte perinatal fueron: hipoxia (aguda o crónica) 28%, infección congénita 23% (preferentemente neumonía 18%), desprendimiento prematuro de placenta con hipoxia y shock hipovolémico 18%, anomalía congénita 18% y síndrome hipertensivo con hipoxia aguda o crónica 7%. Conclusiones: Entre las 22 y 34 semanas de gestación, el parto prematuro por IBA fue la causa más frecuente de muerte perinatal, la edad gestacional al parto fue el principal factor de riesgo de mortalidad y la hipoxia fue la causa más frecuente de muerte. PALABRAS CLAVE: Mortalidad perinatal, nacimiento prematuro, infección congénita SUMMARY Aim:To determine perinatal mortality of premature birth and the risk factors associated using perinatal clinical data, laboratory results and histopathological fetal, neonatal and placental findings. Methods: Retrospective cohort study of 407 preterm single births at 22.0-34.0 weeks gestation. Fetal and neonatal deaths until 7 days of life were studied. One hundred and twenty two children died (64 fetal deaths and 58 neonatal deaths), 78 had autopsy. Results: Perinatal mortality was 30% (122/407). Of total deaths, 71% (87/122) occurred before 30 weeks gestation and 81% (99/122) occurred in very low birth weight infants (<1500 g). The main causes of perinatal mortality according to associated factors for premature birth were: ascending bacterial infection (ABI) 41% (50/122), congenital anomalies 20% (24/122) and hypertension 12% (15/122).

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Mortality risk factors in premature infants with respiratory distress syndrome treated by mechanical ventilation

Cited by 17 publications

References 8 publications

The Incidence of Respiratory Distress Syndrome among Preterm Infants Admitted to Neonatal Intensive Care Unit: A Retrospective Study

The Incidence of Respiratory Distress Syndrome among Preterm Infants Admitted to Neonatal Intensive Care Unit: A Retrospective Study

Clinical profile and outcome of respiratory distress in newborns admitted in rural tertiary health care centre of Maharashtra, India

Mortalidad perinatal en el parto prematuro entre 22 y 34 semanas en un hospital público de Santiago, Chile

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